Musculoskeletal System Development
|Embryology - 24 Aug 2016 Expand to Translate|
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- 1 Introduction
- 2 Some Recent Findings
- 3 Textbooks
- 4 Objectives
- 5 Development Overview
- 6 Shoulder and Pelvis
- 7 References
- 8 Additional Images
- 9 External Links
- 10 Glossary Links
The mesoderm forms nearly all the connective tissues of the musculoskeletal system. Each tissue (cartilage, bone, and muscle) goes through many different mechanisms of differentiation.
The musculoskeletal system consists of skeletal muscle, bone, and cartilage and is mainly mesoderm in origin with some neural crest contribution.
The intraembryonic mesoderm can be broken into paraxial, intermediate and lateral mesoderm relative to its midline position. During the 3rd week the paraxial mesoderm forms into "balls" of mesoderm paired either side of the neural groove, called somites.
Somites appear bilaterally as pairs at the same time and form earliest at the cranial (rostral,brain) end of the neural groove and add sequentially at the caudal end. This addition occurs so regularly that embryos are staged according to the number of somites that are present. Different regions of the somite differentiate into dermomyotome (dermal and muscle component) and sclerotome (forms vertebral column). An example of a specialized musculoskeletal structure can be seen in the development of the limbs.
Skeletal muscle forms by fusion of mononucleated myoblasts to form mutinucleated myotubes. Bone is formed through a lengthy process involving ossification of a cartilage formed from mesenchyme. Two main forms of ossification occur in different bones, intramembranous (eg skull) and endochondrial (eg limb long bones) ossification. Ossification continues postnatally, through puberty until mid 20s. Early ossification occurs at the ends of long bones.
Musculoskeletal and limb abnormalities are one of the largest groups of congenital abnormalities.
- Musculoskeletal Links: Introduction | Mesoderm | Somitogenesis | Limb | Cartilage | Bone | Bone Timeline | Axial Skeleton | Skull | Joint | Muscle | Muscle Timeline | Tendon | Diaphragm | Lecture - Musculoskeletal Development | Abnormalities | Limb Abnormalities | Cartilage Histology | Bone Histology | Skeletal Muscle Histology | Category:Musculoskeletal
Some Recent Findings
|More recent papers|
This table shows an automated computer PubMed search using the listed sub-heading term.
References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.
Katelijne De Wilde, Arne Martens, Stijn Lambrecht, Peggy Jacques, Michael B Drennan, Karlijn Debusschere, Srinath Govindarajan, Julie Coudenys, Eveline Verheugen, Fien Windels, Leen Catrysse, Rik Lories, Dennis McGonagle, Rudi Beyaert, Geert van Loo, Dirk Elewaut A20 inhibition of STAT1 expression in myeloid cells: a novel endogenous regulatory mechanism preventing development of enthesitis. Ann. Rheum. Dis.: 2016; PubMed 27551052
Antonios Vantarakis, Athanasios Chatzinikolaou, Alexandra Avloniti, Nikolaos Vezos, Ioannis I Douroudos, Dimitrios Draganidis, Athanasios Z Jamurtas, Antonis Kambas, Stamatios Kalligeros, Ioannis G Fatouros A Two-month Linear Periodized Resistance Exercise Training Improved Musculoskeletal Fitness and Specific Conditioning of Navy Cadets. J Strength Cond Res: 2016; PubMed 27548791
Julia Siede, Anja Fröhlich, Angeliki Datsi, Ahmed N Hegazy, Domonkos V Varga, Vivien Holecska, Hirohisa Saito, Susumu Nakae, Max Löhning IL-33 Receptor-Expressing Regulatory T Cells Are Highly Activated, Th2 Biased and Suppress CD4 T Cell Proliferation through IL-10 and TGFβ Release. PLoS ONE: 2016, 11(8);e0161507 PubMed 27548066
Carlotta Perucca Orfei, Arianna B Lovati, Marco Viganò, Deborah Stanco, Marta Bottagisio, Alessia Di Giancamillo, Stefania Setti, Laura de Girolamo Dose-Related and Time-Dependent Development of Collagenase-Induced Tendinopathy in Rats. PLoS ONE: 2016, 11(8);e0161590 PubMed 27548063
Stella G Muthuri, Diana Kuh, Rebecca Bendayan, Gary J Macfarlane, Rachel Cooper Chronic physical illness in early life and risk of chronic widespread and regional pain at age 68: evidence from the 1946 British birth cohort. Pain: 2016; PubMed 27547897
| Hill, M.A. (2016). UNSW Embryology (16th ed.) Retrieved August 24, 2016, from https://embryology.med.unsw.edu.au
|Moore, K.L. & Persuad, T.V.N. (2008). The Developing Human: clinically oriented embryology (8th ed.). Philadelphia: Saunders.|
| Schoenwolf, G.C., Bleyl, S.B., Brauer, P.R. and Francis-West, P.H. (2009). Larsen’s Human Embryology (4th ed.). New York; Edinburgh: Churchill Livingstone.
- Identify the components of a somite and the adult derivatives of each component.
- Give examples of sites of endochondral and intramembranous ossification and to compare these two processes.
- Identify the general times of formation of primary and of formation of secondary ossification centres, and of fusion of such centres with each other.
- Briefly summarise the development of the limbs.
- Describe the developmental abnormalities responsible for the following malformations: selected growth plate disorders; congenital dislocation of the hip; scoliosis; arthrogryposis; and limb reduction deformities.
Bone is a connective tissue and develops from mesoderm except in the head where neural crest also contributes. Below is a very brief cartoon overview using simple figures of 3 aspects of early musculoskeletal development. More detailed overviews are shown on other notes pages Mesoderm and Somite, Vertebral Column, Limb in combination with serial sections and Carnegie images.
|Mesoderm beside the notochord (axial mesoderm, blue) thickens, forming the paraxial mesoderm as a pair of strips along the rostro-caudal axis.|
|Paraxial mesoderm towards the rostral end, begins to segment forming the first somite. Somites are then sequentially added caudally. The somitocoel, is a cavity forming in early somites, which is lost as the somite matures.|
|Cells in the somite differentiate medially to form the sclerotome (forms vertebral column) and dorsolaterally to form the dermomyotome.|
| The dermomyotome then forms the dermotome (forms dermis) and myotome (forms muscle).
Neural crest cells migrate beside and through somite.
|The myotome differentiates to form 2 components dorsally the epimere and ventrally the hypomere, which in turn form epaxial and hypaxial muscles respectively. The bulk of the trunk and limb muscle coming from the Hypaxial mesoderm. Different structures will be contributed depending upon the somite level.|
Somite Links: 1 paraxial | 2 early somite | 3 sclerotome and dermomyotome | 4 dermatome and myotome | 5 somite spreading | SEM image - Human Embryo (week 4) showing somites | Movie - somitogenesis Hes expression
Shoulder and Pelvis
The skeletal shoulder consists of: the clavicle (collarbone), the scapula (shoulder blade), and the humerus. Development of his region occurs through both forms of ossification processes.
The skeletal pelvis consists of: the sacrum and coccyx (axial skeleton), and pelvic girdle formed by a pair of hip bones (appendicular skeleton). Before puberty, he pelvic girdle also consists of three unfused bones: the ilium, ischium, and pubis. In chicken, the entire pelvic girdle originates from the somatopleure mesoderm (somite levels 26 to 35) and the ilium, but not of the pubis and ischium, depends on somitic and ectodermal signals.
- Olivier Pourquié Vertebrate segmentation: from cyclic gene networks to scoliosis. Cell: 2011, 145(5);650-63 PubMed 21620133
- Yegor Malashichev, Bodo Christ, Felicitas Pröls Avian pelvis originates from lateral plate mesoderm and its development requires signals from both ectoderm and paraxial mesoderm. Cell Tissue Res.: 2008, 331(3);595-604 PubMed 18087724
- Developmental Biology by Gilbert, Scott F. Sunderland (MA): Sinauer Associates, Inc.; c2000 Paraxial and intermediate mesoderm | Myogenesis: The Development of Muscle | Osteogenesis: The Development of Bones | Figure 14.10. Conversion of myoblasts into muscles in culture
- Molecular Biology of the Cell Alberts, Bruce; Johnson, Alexander; Lewis, Julian; Raff, Martin; Roberts, Keith; Walter, Peter New York and London: Garland Science; c2002 Search Molecular Biology of the CellBone Is Continually Remodeled by the Cells Within ItImage: Figure 22-52. Deposition of bone matrix by osteoblasts.Image: Figure 22-56. The development of a long bone.
Olivier Pourquié Vertebrate segmentation: from cyclic gene networks to scoliosis. Cell: 2011, 145(5);650-63 PubMed 21620133
Katarzyna A Piróg, Michael D Briggs Skeletal dysplasias associated with mild myopathy-a clinical and molecular review. J. Biomed. Biotechnol.: 2010, 2010;686457 PubMed 20508815
Avan Aihie Sayer, Cyrus Cooper Fetal programming of body composition and musculoskeletal development. Early Hum. Dev.: 2005, 81(9);735-44 PubMed 16081228
J M Walker Musculoskeletal development: a review. Phys Ther: 1991, 71(12);878-89 PubMed 1946622
Kimberly E Applegate Can MR imaging be used to characterize fetal musculoskeletal development? Radiology: 2004, 233(2);305-6 PubMed 15516609
Jung Kyu Ryu, Jeong Yeon Cho, Jong Sun Choi Prenatal sonographic diagnosis of focal musculoskeletal anomalies. Korean J Radiol: 2004, 4(4);243-51 PubMed 14726642
Search April 2010
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Cite this page: Hill, M.A. (2016) Embryology Musculoskeletal System Development. Retrieved August 24, 2016, from https://embryology.med.unsw.edu.au/embryology/index.php/Musculoskeletal_System_Development
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