Musculoskeletal System - Tendon Development: Difference between revisions
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Scleraxis may also have additional roles in other tissues such as in early [[Cardiovascular System Development|heart]] valve development.<ref name=PMID24983472><pubmed>24983472</pubmed></ref> | Scleraxis may also have additional roles in other tissues such as in early [[Cardiovascular System Development|heart]] valve development.<ref name=PMID24983472><pubmed>24983472</pubmed></ref> | ||
* Cytogenetic location: 8q24.3 | |||
:'''Links:''' [http://www.ncbi.nlm.nih.gov/gquery/?term=Scleraxis NCBI databases - Scleraxis] | :'''Links:''' [http://www.ncbi.nlm.nih.gov/gquery/?term=Scleraxis NCBI databases - Scleraxis] | [http://omim.org/entry/609067 OMIM 609067] | ||
==Histology== | ==Histology== |
Revision as of 10:59, 8 July 2014
Embryology - 26 Apr 2024 Expand to Translate |
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Introduction
This page describes skeletal tendon development, during formation of the connective tissue connection muscle to bone.
The syndetome is the embryonic structural origin of tendons from the somite and originates from the dorsolateral edge of the sclerotome. Expression of the basic helix-loop-helix (bHLH) transcription factor scleraxis (SCX) in early progenitor cells is thought to be key regulator in the formation of tendon and ligament tissues.[1] Scleraxis may also have additional roles in other tissues such as in early heart valve development.[2]
The origins of some muscles and tendons in the head differ from those found in the remained of the body.
See also notes Connective Tissue Development.
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Tendon development <pubmed limit=5>Tendon+development</pubmed> |
Molecular
Mesoderm Development and Pax[6]
dark green - syndetome originates from the dorsolateral edge of the sclerotome, as Pax1 and Pax9 are downregulated and scleraxis (Scx) upregulation leads to syndegenesis. Pax, paired homeobox; MYOD1, myogenic differentiation antigen 1; MYF5, myogenic factor 5; NKX, NK homeobox; SCX, scleraxis.
Scleraxis
Scleraxis (SCX) is a member of the basic helix-loop-helix (bHLH) transcription factor family. It is expressed in early mesoderm progenitor cells and may regulate the formation of tendon and ligament tissues.[1]
Scleraxis may also have additional roles in other tissues such as in early heart valve development.[2]
- Cytogenetic location: 8q24.3
- Links: NCBI databases - Scleraxis | OMIM 609067
Histology
References
Reviews
Articles
<pubmed>12705871</pubmed>
Search PubMed
Search Pubmed: Tendon Development | myotendinous junction development
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Cite this page: Hill, M.A. (2024, April 26) Embryology Musculoskeletal System - Tendon Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Musculoskeletal_System_-_Tendon_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G