Difference between revisions of "Integumentary System Development"

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Revision as of 17:13, 14 August 2017

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Introduction

Skin Cartoon

The integumentary system covers the surface of the embryo (skin) and its specialized skin structures including hair, nails, sweat glands, mammary glands and teeth. As a system it has contributions from all embryonic layers.


The skin provides a barrier between ourselves and our environment, it also contains specializations in different regions including hair, nails, glands and sensory receptors. In other species, additional specializations such as feathers, horns and shell can be seen.

The two major tissue organizations of epithelial (ectoderm, epidermis) and mesenchyme (mesoderm connective tissue, dermis and hypodermis) are shown within skin. In addition, we have aslo extensive populating by melanocytes (neural crest) and sensory nerve endings. It remains today as possibly the first epithelial specialization from which other epithelial specializations arose that are now located inside the body.

Ectoderm forms the surface epidermis and the associated glands. Mesoderm, from the somites, forms the underlying connective tissue of dermis and hypodermis. Neural crest cells also migrate into the forming epidermis and the skin is also populated by specialized sensory endings. Fetal skin also has the ability to heal wounds without a scar in contrast to adult skin, this may relate to differences in the fetal extracellular matrix structure. The adult epidermis contains keratinocytes, melanocytes and Langerhans cells.

Tinycc  
http://tiny.cc/Integument_Development
Integumentary Links: integumentary | Lecture | hair | tooth | nail | integumentary gland | mammary gland | vernix caseosa | melanocyte | touch | Eyelid | outer ear | Histology | integumentary abnormalities | Category:Integumentary
Hair Links  
Hair Links: Overview | Lanugo | Neonatal | Vellus | Terminal | Hair Follicle | Follicle Phases | Stem Cells | Molecular | Pattern | Puberty | Histology | Hair Colour | Arrector Pili Muscle | Hair Loss | Integumentary
Touch Links  
Touch Links: Touch Receptors | Touch Pathway | Pacinian Corpuscle | Meissner's Corpuscle | Merkel Cell | Sensory Modalities | Neural Crest Development | Neural System Development | Student project | Integumentary | Sensory System
Historic Embryology - Integumentary  
1906 Papillary ridges | 1910 Manual of Human Embryology | 1914 Integumentary | 1923 Head Subcutaneous Plexus | 1921 Text-Book of Embryology | 1924 Developmental Anatomy | 1941 Skin Sensory | Historic Disclaimer
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Some Recent Findings

  • Comparison between human fetal and adult skin[1] Healing of early-gestation fetal wounds results in scarless healing. Since the capacity for regeneration is probably inherent to the fetal skin itself, knowledge of the fetal skin composition may contribute to the understanding of fetal wound healing. The aim of this study was to analyze the expression profiles of different epidermal and dermal components in the human fetal and adult skin."
  • The integumentary skeleton of tetrapods: origin, evolution, and development[2] "Three types of tetrapod integumentary elements are recognized: (1) osteoderms, common to representatives of most major taxonomic lineages; (2) dermal scales, unique to gymnophionans; and (3) the lamina calcarea, an enigmatic tissue found only in some anurans."
More recent papers  
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Search term: Integumentary Embryology

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Textbooks

Adult epidermis structure. See also molecular markers[3]
  • Human Embryology (2nd ed.) Larson Chapter 14 p443-455
  • The Developing Human: Clinically Oriented Embryology (6th ed.) Moore and Persaud Chapter 20: P513-529
  • Before We Are Born (5th ed.) Moore and Persaud Chapter 21: P481-496
  • Essentials of Human Embryology Larson Chapter 14: P303-315
  • Human Embryology, Fitzgerald and Fitzgerald
  • Color Atlas of Clinical Embryology Moore Persaud and Shiota Chapter 15: p231-236

Objectives

  • Understand the differentiation of the epidermis and dermis.
  • Understand the formation of hair and nails.
  • Understand the formation of sweat glands, mammary glands.
  • Understand the formation of teeth.

Development Overview

Human Embryo (Week 8, Stage 22) Integument

Ectoderm and Mesoderm Origin

4 weeks

  • simple ectoderm epithelium over mesenchyme.

1-3 months

  • ectoderm - germinative (basal) cell repeated division of generates stratified epithelium.
  • mesoderm - differentiates into connective tissue and blood vessels.
  • week 11 - (GA week 13) blood vessels visible in the early fetal skin, small blood vessels in the upper papillary region and larger vessels in the deep reticular dermis.[1]

4 months

Fetal integumentary histology 01.jpg

Fetal human integumentary histology[1] (Weeks in figure are from LMP)

  • Basal cell - proliferation generates folds in basement membrane.
  • Neural crest cells - melanoblasts migrate into epithelium. These are the future melanocyte pigment cell of the skin.
  • Embryonic connective tissue- differentiates into dermis, a loose ct layer over a dense ct layer. Beneath the dense ct layer is another loose ct layer that will form the subcutaneous layer.
  • Ectoderm contributes to nails, hair follictles and glands.
  • Nails form as thickening of ectoderm epidermis at the tips of fingers and toes. These form germinative cells of nail field.
  • Cords of these cells extend into mesoderm forming epithelial columns. These form hair follocles, sebaceous and sweat glands.

5 months

  • Hair growth initiated at base of cord, lateral outgrowths form associated sebaceous glands.
  • Other cords elongate and coil to form sweat glands.
  • Cords in mammary region branch as they elongate to form mammary glands. These glands will complete development in females at puberty. Functional maturity only occurs in late pregnancy.

Embryonic and Fetal Epidermis

Electron Micrographs of the Developing Human Epidermis[4]

Human embryo skin 8-9 week EGA.jpg

6 to 8 weeks (8-9 week EGA)

Human embryo skin 9-11 week EGA.jpg

7 to 9 weeks (9-11 week EGA)

Human embryo skin 24 week EGA.jpg

22 weeks (about 24 week EGA)

Dermis

Somite Components
Somite Components

The underlying connective tissue layers of the skin (dermis and hypodermis) arise from the dermatome component of the developing somite.

cartoon of the dermatome

Cartoon showing the dermatome component of the somite.[5]

Fetal Dermis

Fetal Dermis (18 wk LMP)[1]

The following data is from an immunohistological study of fetal skin dermis layer.[1]

  • Collagen type I is the principal component of extracellular matrix (ECM) (also in adult skin).
  • Collagen type III high ratio to collagen type I (than adult skin).
  • Glycosaminoglycans (GAGs) level higher (than adult skin).
  • Hyaluronic acid and chondroitin sulfate both higher.
  • Elastin was not present (found in adult skin).

Vernix Caseosa

Newborn vernix caseosa
Newborn vernix caseosa

Has several different potential functions and a variable composition.[6]

  • a highly variable coating of the fetal skin
  • high water content (80%) largely compartmentalized within fetal corneocytes (cells forming the stratum corneum)
  • develops cranio-caudally production coincides in utero with terminal differentiation of the epidermis and formation of the stratum corneum
  • primarily composed of sebum, cells that have sloughed off the fetus's skin and shed lanugo hair
  • can be absent in preterm infants
  • dehydration and rehydration processes occur two to four times faster at 37 degrees celcius than at room temperature[7]
  • towards term fragments of vernix can mix into the amniotic fluid resulting in (normal) turbidity
  • fetal swallowing of amniotic fluid mixed with fragments of vernix can also occur


Links: Gland Development

Adult Epidermal Stem Cells

In adult human skin epithelium, keratinocytes take about a month to differentiate from the basal stem cell layer, through the different stages of differentiation and layers, to be finally sloughed off on the surface. As well as keratinocyte differentiation, this represents a specialised form of programmed cell death called "cornification".

Epidermis stem cell models[3]

The following information is from a recent study on mouse skin using a single cell labelling system with longitudinal tracing and confocal imaging.[8]

Organization of the epidermis. Hair follicles contain stem cells located in the bulge (b, green), with the potential to generate lower hair follicle (lf), sebaceous gland (sg, orange) upper follicle (uf) and interfollicular epidermis (IFE, beige). The schematic shows the organization of keratinocytes in the IFE, as proposed by the stem/TA cell hypothesis. The basal layer comprises stem cells (S, blue), transit amplifying cells (TA, dark green), and post-mitotic basal cells (red), which migrate out of the basal layer as they differentiate (arrows).

Hair follicle development.jpg

Projected Z-stack confocal images of IFE wholemounts from AhcreERT R26EYFP/wt mice viewed from the basal surface at the times shown following induction. Yellow, EYFP; blue, DAPI nuclear stain. Scale bar, 20 microns.

Reprinted by permission from Macmillan Publishers Ltd: Nature. 2007 Mar 8;446(7132):185-9, copyright (2007)

Adult epidermal stem cells[8] "According to the current model of adult epidermal homeostasis, skin tissue is maintained by two discrete populations of progenitor cells. ...Here we show that clone-size distributions are consistent with a new model of homeostasis involving only one type of progenitor cell. These cells are found to undergo both symmetric and asymmetric division at rates that ensure epidermal homeostasis."


Links: MRC - Phil Jones Laboratory

Melanocytes

Melanoblast migration.png
Mouse-melanoblast migration icon.jpg
 ‎‎Mouse Melanoblast
Page | Play

Neural crest cells lying lateral to a region between the dermamyotome and the surface ectoderm (migration staging area) further migrate to populate the embryonic skin as proliferating melanoblasts. These initial melanoblasts are unpigmented containing only immature melanosomes without functional tyrosinase (TYR), the enzyme required for melanin synthesis.

See also modeling melanoblast development.[9]


Gene Regulatory Network (GRN)

  • Sox10 in antagonising Mitfa-dependent melanocyte differentiation (zebrafish)[10]
  • Melanocyte differentiation controlled by microphthalmia transcription factor (MITF).
    • activates genes involved in pigment production - TYR, TRP-1 and TRP-2


Melanin pigments

The Fitzpatrick skin phototype (I-VI, light to dark) is used to classify skin colour based on the amount of melanin pigment in the skin. There are two mani forms of pigment:

  1. eumelanin - brown-black or dark insoluble polymer, (dark skin and hair)
  2. pheomelanin - red-yellow soluble polymer, formed by the conjugation of cysteine or glutathione. (red hair and skin phototypes I and II)
Fitzpatrick Skin Phototype 
Type Features Tanning ability
I Pale white skin, blue/green eyes, blond/red hair Always burns, does not tan
II Fair skin, blue eyes Burns easily, tans poorly
III Darker white skin Tans after initial burn
IV Light brown skin Burns minimally, tans easily
V Brown skin Rarely burns, tans darkly easily
VI Dark brown or black skin Never burns, always tans darkly
Reference: Fitzpatrick TB. Soleil et peau. (1975) J Med Esthet. 2: 33-34.
Links: Neural Crest Development | MITF

Keratin

Intermediate Filament protein family

Cytoskeleton intermediate filament protein of epithelial cells required for cell mechanical stability and integrity, humans have 54 functional keratin genes. The α-keratins are expressed in all vertebrates, while the β-keratins are specific to birds and reptiles.Cite error: Closing </ref> missing for <ref> tag "Elaine Fuchs has collected many awards in her 30 years researching mammalian skin development, but it's hard to beat the two prizes she received in late 2009. Shortly before winning the prestigious L'Oreál-UNESCO award for women in science, Fuchs was awarded the National Medal of Science—the US's highest honor for outstanding scientific contributions."

Links: Lecture Cytoskeleton - Intermediate Filaments

Integrin Expression

The data below form a research article identifies expression of integrin subunits during development of human palm and sole skin.[11]

  • All of the integrins expressed during development were also present in mature epidermis and were largely confined to the basal layer of keratinocytes in a pericellular distribution.
  • alpha 3 and beta 1 subunits - were expressed prior to the initiation of stratification and did not change in abundance or distribution during subsequent development.
  • alpha 4 and beta 3 - were not detected at any time in the epidermis.

Every other subunit examined showed spatial or temporal changes in expression.

  • alpha 1 - was strong before stratification and until mid-development, but was greatly decreased in neonatal epidermis.
  • alpha 2 - was first detected in small patches of basal cells prior to stratification, and thereafter was found in the entire basal layer, with greater staining in developing sweat glands.
  • alpha 5 - was not expressed until mid-development, and then primarily in developing sweat glands, with faint expression in neonatal epidermis.
  • alpha v - was detected following stratification, in developing sweat glands, and occasionally in neonatal epidermis.
  • alpha 6 and beta 4 - were peribasally expressed before stratification. After stratification became concentrated at the basal cell surface in contact with the basement membrane, co-localizing with hemidesmosomes.

Three known ligands for keratinocyte integrins

  • laminin and collagen type IV - present in the basement membrane zone at all stages of development
  • fibronectin - only evident until about 13 weeks estimated gestational age.


Langerhans Cells

Langerhans cells (LCs) are immune system dendritic cells (myeloid antigen-presenting immune cells) found in the basal/suprabasal layers of stratified epidermis (and also in epithelia of the corneal and mucosal tissues). These migratory dendritic cells belong to the same cell family as microglia (see review[12])

In the embryo, LC precursors first form from the primitive yolk sac macrophages, and later in the fetal liver from a monocyte-like precursor. Langerhans cells then populate the single-layered epidermis and undergo local proliferation before birth.[13]

Postnatally, local self-renewal maintains or restores LC numbers following low grade or chronic inflammation.


History - Paul Langerhans (1847 – 1888)[14] in 1868 first (mis)identified these cells as neurons.


Links: Immune System Development | Search Pubmed

Other Species

Chicken

The avian integumentary system includes integumentary specialisations such as feathers, scales, claws, and beaks.

  • β-keratin - expressed in embryonic feathers[15]
Links: Chicken Development


References

  1. 1.0 1.1 1.2 1.3 1.4 <pubmed>19701759</pubmed>| PMC2799629 | Arch Dermatol Res
  2. <pubmed>19422424</pubmed>
  3. 3.0 3.1 <pubmed>18209104</pubmed>JCB
  4. <pubmed>2413039</pubmed>| PMC2113922
  5. <pubmed>24496612</pubmed>| Development
  6. <pubmed>11069626</pubmed>
  7. <pubmed>17671513</pubmed>
  8. 8.0 8.1 <pubmed>17330052</pubmed>
  9. <pubmed>22915137</pubmed>
  10. <pubmed>21909283</pubmed>
  11. <pubmed>1769328</pubmed>
  12. <pubmed>26554892</pubmed>
  13. <pubmed>24190429</pubmed>
  14. <pubmed>11919207</pubmed>
  15. <pubmed>26598683</pubmed>


Reviews

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Articles

<pubmed></pubmed> <pubmed></pubmed> <pubmed>20592759</pubmed> <pubmed>12199909</pubmed> <pubmed>2413039</pubmed>

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Search Pubmed: Integumentary Development | Skin Development | Hair Development | Tooth Development | Vernix Caseosa

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Additional Images

Category:Integumentary

Terms

Integumentary Terms  
Integumentary Development
  • acrosyringium - coiled intra-epidermal region of the eccrine gland sweat duct.
  • apocrine gland - (sweat gland) proteinaceous secretion associated with hair (axilla, areola, genital and anal regions). Additional glands associated with eyelashes are called the glands of Moll (ciliary gland). (More? image - apocrine secretion)
  • arrector pili muscle - bundle of smooth muscle associated with hair follicle, inserts into the papillary layer of the dermis and attaches to the dermal sheath of the hair follicle. (More? image - arrector pili muscle)
  • Blaschko lines - (lines of Blaschko) may represent pathways of epidermal cell migration and proliferation during development. Specific type of lupus erythematosus shows this distinctive pattern. Named after Alfred Blaschko a German dermatologist who first described the feature in 1901. (More? PMID 21396561 | Historic Terminology)
  • bulb - the hair follicle enlargement located at its deepest end, dividing cells form the hair and the root sheath.
  • café-aut-lait macule - (French, cafe-au-lait = coffee with milk; birthmark) describes the characteristic colour of the skin hyperpigmented patch present at birth (congenital) or appearing in early infancy. Common single feature, multiple are associated with various genetic syndromes including Neurofibromatosis type 1 and 2.
  • corneocytes - terminally differentiated keratinocytes forming the stratum corneum.
  • cutis - alternative term for the epidermis and the dermis layers of the skin.
  • dermal papillae - interdigitation of the dermis with the epidermis.
  • dermatoglyphic patterns - (Greek, derma = "skin", glyph = "carving") fingers, palms, toes, and soles skin patterns.
  • dermis - connective tissue middle layer of the skin, consists of two sublayers (papillary and reticular layers) that do not have a clear boundary. Embryologically derived from the somite dermatome.
  • dermomyotome - Early embryonic dorsolateral half of the somite that will later divide to form both the dermatome and myotome. The dermatome will contribute the dermis and hypodermis of the skin. The myotome will contribute the skeletal muscle of muscoloskeletal system. Development sequence: mesoderm to paraxial mesoderm to somite to "dermomyotome" then dermatome and myotome. (More? Somitogenesis | Musculoskeletal System Development | Integumentary System Development)
  • eccrine gland (Greek, ekkrinein = "secrete"; merocrine glands) sweat glands unique to some primates and used in humans for thermoregulation. Adult body has 2 to 4 million sweat glands with concentrations (700/cm) on the palms of the hand, soles of the feet and forehead. Secretion is timulated by sympathetic nervous system, post-ganglionic cholinergic branch, and other stimuli
  • ephilis - (pl., ephilides; freckle) Clinical term describing a "freckle", that is a small brown or tan mark on the skin. These inherited features result from a copy of variant Melanocortin 1 Receptor (MC1R) gene and are common on fair skinned Celtic children. Melanocytes produce locally more melanin, this can also increase following exposure to ultraviolet radiation in sunlight. (More? Integumentary | Neural Crest | OMIM MC1R)
  • epidermis - Histological term describing the external cellular epithelial layer of the integumentary (skin) covering the entire body. This surface layer of keratinocytes is ectoderm in origin, while the underlying connective tissue layers of dermis and hypodermis are mesoderm in origin. (More? Integumentary Development)
  • epidermal differentiation complex - (EDC) human chromosome (1q2) containing linked 63 genes within four gene families that are molecular markers for stratified epidermis terminal differentiation.
  • epidermal growth factor receptor - expressed on cells in the epidermis basal layer, signaling stimulates both epidermal growth and wound healing and also mediates an inhibition of differentiation.
  • glabrous skin - skin without hair, refers to the palms of hands and soles of feet.
  • hair - (pili) in humans consists of vellus and terminal hairs.
  • holocrine - form of gland secretion where the secretory cells eventually lyse (rupture) and are lost. On the skin, these cells release sebum consisting mainly of lipid. (More? image - holocrine secretion)
  • hypodermis - (subcutis, subcutaneous adipose) a connective tissue ilower layer of the skin that binds it to underlying structures.
  • integumentary - term for the skin and its appendages.
  • involucrin - protein that binds loricrin in the development of the cell envelope protecting corneocytes in the skin.
  • keratinocyte - the main cell type forming the layers of the epidermis, derived from ectoderm.
  • keratohyalin granule - found in the stratum granulosum consist of profilaggrin and loricrin.
  • Langerhans cell - skin dendritic cell (antigen presenting cell) develops initially from fetal liver monocytes and yolk sac macrophages. May, depending on the immunological setting, elicit immunity or tolerance. Named after Paul Langerhans.
  • Langer's lines - (skin cleavage lines, cleavage lines) Clinical term for the orientation of reticular dermis collagen bundles causing tensions on skin and subcutaneous tissues. Lines tend to be horizontal in the trunk and neck, and longitudinal in the skin and limbs. (More? PMID 15791423)
  • Meissner corpuscle - sensory structure acting as a rapidly-adapting mechanoreceptor mainly in the dermal papillae of (digital) skin. (More?Touch
  • melanin - (Greek, melanos = black) The pigment produced by melanocytes that provides photoprotection, preventing cellular DNA damage, and colouring of the basal epithelial cells that absorb the pigment.
  • melanodermia - hyperpigmentation causing abnormal darkening (brown/black) of the skin due to excess melanin or by metallic substances. See also the abnormality ceruloderma (blue/grey). (More? PMID 23522626)
  • melanocyte - (Greek, melanos = black) A pigmented cell, neural crest in origin, differentiating from melanoblasts located in the skin and other tissues that produces melanin. The melanocytes within the integument (skin) transfer melanin to keratinocytes to give skin colour and to the hair follicle to give hair colour. Melanocytes are also located within "non-cutaneous" tissues in the eye (for eye colour), harderian gland and inner ear. This is the cell type that proliferates in the cancer melanoma. (More? Neural Crest Development | Integumentary System Development)
  • Merkel cell - An epidermal-derived cell in touch-sensitive area of the epidermis and mediate mechanotransduction in the skin. Previously thought to be neural crest in origin, but recently shown to arise from the embryonic epithelium. The cells are named after Friedrich Sigmund Merkel, a German anatomist who was the first to describe them in 1875. (More? Touch | Lecture - Integumentary Development | PMID 19786578 | PMID 3782861)
  • merocrine gland - (sweat gland, eccrine sweat) simple tubular glands located at the border between the dermis and hypodermis. These glands regulate the body temperature. (More? image - merocrine secretion)
  • nestin - (neuroectodermal stem cell marker) an intermediate filament protein (type VI) expressed in stem cells and transiently during development, and in cells within hair follicles, sebaceous and sweat glands.
  • papillary layer - dermis sublayer that appears less dense and contains more cells lying close beneath the epidermis. (More? image)
  • pilosebaceous unit - term used to describe a hair and its associated structures: hair follicle, arrector pili muscle and sebaceous gland.
  • rete ridge - the extensions of the epidermis into the dermis. These epidermal surface thickenings extend downward between underlying connective tissue dermal papillae. This is also the site of initial eccrine gland differentiation.
  • reticular layer - dermis sublayer that appears denser and contains fewer cells with thick collagen bundles lying beneath the papillary layer parallel to the skin surface. (More? image)
  • root sheath - cell layers that surround the hair.
  • sebaceous gland - holocrine gland associated with both the hair follicle and hairless parts of the skin (lips, cheek oral surface and external genitalia). Embedded in the dermis and are sites of infections (acne).
  • simple - consisting of a single cell layer.
  • terminal hairs - hair seen in obviously hairy parts of the body.
  • thick skin - refers to the skin histology found on the palms of the hand and soles of the feet, does not contain hair. Note that this is used as a histological term not a measurement of overall skin thickness.
  • thin skin - refers to the skin histology found on skin on all body regions, other than palms and soles (thick skin).
  • vellus hairs - fine short hairs only lightly pigmented covering the body.
  • vernix caseosa - (vernix, Latin, "caseosa" = cheese-like) a fetal protective coating consisting of sebum, skin cells and lanugo hair. Forming late in fetal development in a rostra-caudal sequence associated with epithelium differentiation.
  • Voigt's lines - clinical term to describe the skin borders between areas of innervations by specific peripheral cutaneous nerves. (More? Sensory Touch | Historic Terminology)
Other Terms Lists  
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Cite this page: Hill, M.A. (2020, November 25) Embryology Integumentary System Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Integumentary_System_Development

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