Gastrointestinal 3D stage 13 Movie

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<html5media height="580" width="550">File:Stage13 GIT3d.mp4</html5media>

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Gastrointestinal and Respiratory

Based upon a serial reconstruction from individual embryo slice images. (6 mm pig embryo, approximately Human day 32, Carnegie Stage 13/14 embryo, week 5)

The endoderm and mesoderm initially contribute many structures in the gastrointestinal tract, respiratory and renal systems. Note the relative size and position of individual structures and organs at this early stage of development. Below the animation is a more complete description of each system.

Colour code:

  • Foregut - oropharyngeal membrane, oesophagus, pharynx (dark salmon - Foregut, oropharyngeal membrane, oesophagus, pharynx)
  • Trachea and Lung Buds (dark blue - Trachea and Lung Buds)
  • Mesonephros (yellow - mesonephros)
  • Mesonephric Ducts (light blue - mesonephric ducts)

Links: MP4 version | Gastrointestinal Tract Development | Respiratory System Development | Renal System Development

Carnegie Stage 13 Movies: Gastrointestinal Tract | Cardiovascular | Central Nervous System | Carnegie Stage 13 | Stage 22 Movies | Movies

The original animations were part of the UNSW Independent Learning Project (ILP) prepared by Aashish Kumar (2006).
Stage 13 Links: Week 4 | Week 5 | Somitogenesis | Placodes | Head | Movies | Lecture - Early Vascular | Lecture - Gastrointestinal | Lecture - Head Development | Science Practical - Gastrointestinal | Science Practical - Head | Carnegie Embryos | Category:Carnegie Stage 13 | Next Stage 14
  Historic Papers: 1905 Embryo 148 | 1926 Precervical Sinus | 1945 | 1955

Gastrointestinal Tract

The gastrointestinal tract (GIT) develops primarily from the endoderm, with inputs from the mesoderm (splanchnic mesoderm) and the ectoderm (neural crest cells form its primary nerve plexus, enteric plexus). After the endoderm is folded into a blind-ended tube in week 4, it begins to develop into the primary lining of the GIT, while the mesoderm provides its muscular wall and connective tissues components. The GIT is typically partitioned into 3 parts, based on their separate blood supplies: foregut, midgut and hindgut, with the allantois coming off the hindgut. A bud coming off the tract forms the liver; eventually buds appear that form gallbladder and pancreas. The rostral end of the tube ends at the buccopharyngeal membrane, where it interacts with ectoderm directly (no mesoderm in between). This area forms the future mouth. A similar endodermal-ectodermal interaction occurs at the tail the cloacal membrane. The section of the GIT here is called the cloaca. During week 4, the tube begins to dilate in a certain region, with the dorsal border growing more rapidly than the ventral. This establishes the greater and lesser curvatures of the stomach. The stomach also rotates 90o along the longitudinal axis. On day 22, a small endodermal thickening is visible on the ventral side of the duodenum this becomes the hepatic diverticulum that forms the liver over the next few days. The liver has an important in blood formation. As early as the fourth week, red blood cells production moves to the liver, as opposed to blood islands in the extraembryonic mesoderm.

Links: Gastrointestinal Tract Development

Respiratory System

The respiratory system is endodermal in origin, initially "budding off" the foregut during week 3. This bud forms the respiratory diverticulum, at the level of the glottis between the adult oesophagus and trachea. It continues to bud in week 4, forming a pair of lung buds.

Links: Respiratory System Development


The kidneys develop from intermediate mesoderm, which lies between the lateral plate mesoderm and the somites. The kidney develops in multiple stages, which occur in a rostrocaudal sequence. The earliest structure to form is the pronephros, in week 4, featuring a pronephric duct with associated nephrogenic mesenchyme. This degenerates early on, leaving only the duct system running down to the cloaca, this becomes known as the mesonephric duct, in the embryo. The next stage is the formation of the mesonephros, also in week 4. Its differentiation is induced by the pronephros. However, the mesonephros is also a transient structure. It provides a template for the adult metanephros, beginning on day 35-37.

Links: Renal System Development

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Cite this page: Hill, M.A. (2024, June 16) Embryology Gastrointestinal 3D stage 13 Movie. Retrieved from

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G