Foundations Lecture - Introduction to Human Development: Difference between revisions
mNo edit summary |
mNo edit summary |
||
Line 24: | Line 24: | ||
|} | |} | ||
==Aims== | ==Aims=== | ||
# Purpose of learning embryology | # Purpose of learning embryology | ||
# Basic facts about early human development | # Basic facts about early human development | ||
Line 35: | Line 35: | ||
'''Background Lectures:''' Cell Structure (structure and function), Cell Division (mitosis, meiosis, lifespan, cell death), 4 Basic Tissues (Epithelial, Connective, Muscular, Nervous) | '''Background Lectures:''' Cell Structure (structure and function), Cell Division (mitosis, meiosis, lifespan, cell death), 4 Basic Tissues (Epithelial, Connective, Muscular, Nervous) | ||
'''Links:''' [[Foundations_Practical_-_Introduction_to_Human_Development| | '''Links:''' [[Foundations_Practical_-_Introduction_to_Human_Development|2014 Practical]] | [[Embryology Textbooks]] | ||
==Human Development Timeline== | ===Four Basic Tissue Types=== | ||
[[File:Stomach_histology_001.jpg|thumb|Stomach Wall containing all 4 basic tissues.]] | |||
Tissues and organs of the body consist of combinations of 4 basic tissue organisations: | |||
# Epithelial | |||
# Connective | |||
# Muscular | |||
# Nervous | |||
* Where do they come from? | |||
* How do they develop? | |||
===Human Development Timeline=== | |||
[[File:Human development timeline graph 02.jpg]] | [[File:Human development timeline graph 02.jpg]] | ||
Line 54: | Line 67: | ||
|} | |} | ||
==UNSW Embryology Online== | ==Embryology Education Support== | ||
===UNSW Embryology Online=== | |||
Line 73: | Line 87: | ||
Using these resources (online navigation, organization and printing) will be covered in the introduction to the associated Practical class. | Using these resources (online navigation, organization and printing) will be covered in the introduction to the associated Practical class. | ||
===Glossary Links=== | |||
==Textbooks== | :[[A|A]] | [[B|B]] | [[C|C]] | [[D|D]] | [[E|E]] | [[F|F]] | [[G|G]] | [[H|H]] | [[I|I]] | [[J|J]] | [[K|K]] | [[L|L]] | [[M|M]] | [[N|N]] | [[O|O]] | [[P|P]] | [[Q|Q]] | [[R|R]] | [[S|S]] | [[T|T]] | [[U|U]] | [[V|V]] | [[W|W]] | [[X|X]] | [[Y|Y]] | [[Z|Z]] | [[Numbers|Numbers]] | [[Symbols|Symbols]] | ||
===Textbooks=== | |||
* There are many different excellent embryology textbooks | * There are many different excellent embryology textbooks | ||
* I have included 2 that cover the clinical topics as well. [[Embryology_Textbooks|More Textbooks?]] | * I have included 2 that cover the clinical topics as well. [[Embryology_Textbooks|More Textbooks?]] | ||
Line 147: | Line 163: | ||
:'''Links:''' [[Embryology_Textbooks|More Embryology Textbooks]] | :'''Links:''' [[Embryology_Textbooks|More Embryology Textbooks]] | ||
==Human Reproductive Cycle== | ==Human Reproductive Cycle== | ||
Line 183: | Line 186: | ||
* release millions of spermatozoa (require activation, capacitation) | * release millions of spermatozoa (require activation, capacitation) | ||
==Ovary== | ===Ovary=== | ||
* Paired organs | * Paired organs | ||
* lying in the peritoneal cavity | * lying in the peritoneal cavity | ||
Line 189: | Line 192: | ||
[[File:Ovary10x.jpg|400px]] | [[File:Ovary10x.jpg|400px]] | ||
==Ovulation== | ===Ovulation=== | ||
[[File:Menstrual_cycle.png|thumb|Human Menstrual Cycle]] | [[File:Menstrual_cycle.png|thumb|Human Menstrual Cycle]] | ||
* [[O#ovulation|ovulation]] is the release of the egg (oocyte) at about the middle of the [[Menstrual Cycle|menstrual cycle]] | * [[O#ovulation|ovulation]] is the release of the egg (oocyte) at about the middle of the [[Menstrual Cycle|menstrual cycle]] | ||
Line 199: | Line 202: | ||
[[File:Ovulation_icon.jpg|150px|link=Rabbit Ovulation Movie]] [[File:Follicle 001 icon.jpg|150px|link=Ovulation Movie]] | [[File:Ovulation_icon.jpg|150px|link=Rabbit Ovulation Movie]] [[File:Follicle 001 icon.jpg|150px|link=Ovulation Movie]] | ||
==Fertilization== | ===Trimesters=== | ||
[[File:Human development timeline graph 02.jpg|300px|Trimesters]] | |||
* Divide the pregnancy into 3 "blocks" of about 3 months (trimesters) | |||
* First Trimester - embryonic period (organogenesis) | |||
* Second and Trimester - fetal period (growth) | |||
==First Trimester== | |||
* Embryonic Period - Week 1 to 8 (first trimester) | |||
* Establish the basic structure of organs and tissues (Organogenesis) | |||
* development and growth of the placenta (Placentation) | |||
[[File:Human_Carnegie_stage_1-23.jpg]] | |||
[[File:Embryo stages 002 icon.jpg|120px|link=Embryonic Development]] | |||
===Fertilization=== | |||
* the process of the 2 [[H#haploid|haploid]] [[G#gamete|gametes]] (egg and sperm) fusing and combining genetic material. | * the process of the 2 [[H#haploid|haploid]] [[G#gamete|gametes]] (egg and sperm) fusing and combining genetic material. | ||
* '''conceptus''' - the entire product of fertilization | * '''conceptus''' - the entire product of fertilization | ||
Line 208: | Line 225: | ||
[[File:Early_zygote.jpg]] | [[File:Early_zygote.jpg]] | ||
== | ===Week 1=== | ||
[[File: | * occurs freely floating in uterus | ||
[[File:Week1 001 icon.jpg|90px|link=Week 1 Movie]] | |||
* occurs during [[Week_1|week 1]] following fertilization | * occurs during [[Week_1|week 1]] following fertilization | ||
* last menstrual period (LMP) week 3 | * last menstrual period (LMP) week 3 | ||
Line 218: | Line 238: | ||
[[File:Human_blastocyst_day_1-6.jpg|link=Blastocyst Day 3-6 Movie]] | [[File:Human_blastocyst_day_1-6.jpg|link=Blastocyst Day 3-6 Movie]] | ||
[[File:Week1_summary.jpg]] | [[File:Week1_summary.jpg]] | ||
===Week 2=== | |||
==Week 2 | |||
* Implantation - initial attachment to uterine wall, and then invasion of the uterine wall. | * Implantation - initial attachment to uterine wall, and then invasion of the uterine wall. | ||
Line 233: | Line 246: | ||
[[File:Chorion 001 icon.jpg|120px|link=Chorionic_Cavity_Movie]] | [[File:Chorion 001 icon.jpg|120px|link=Chorionic_Cavity_Movie]] | ||
== | ====Abnormal Implantation==== | ||
==Implantation | |||
= | |||
[[File:Tubal_pregnancy.gif|right]] | [[File:Tubal_pregnancy.gif|right]] | ||
* Ectopic Sites | * Ectopic Sites | ||
Line 256: | Line 253: | ||
* Uterine - tubal pregnancy (most common ectopic) | * Uterine - tubal pregnancy (most common ectopic) | ||
===Normal Implantation=== | ====Normal Implantation==== | ||
* Uterine body | * Uterine body | ||
** posterior, anterior, superior, lateral (most common posterior) | ** posterior, anterior, superior, lateral (most common posterior) | ||
** inferior implantation - placenta overlies internal os of uterus '''Placenta Previa''' | ** inferior implantation - placenta overlies internal os of uterus '''Placenta Previa''' | ||
====Detect Pregnancy==== | |||
[[File:Pregnancy_test.gif|thumb|pregnancy test]] | |||
[[File:Ovary_corpus_luteum.jpg|thumb|Ovary - corpus luteum secretes hormone to support pregnancy.]] | |||
* Clinically can be detected following implantation (week 2) | |||
* Last Menstrual Period (LMP) - today ? ....... Birth Date - January 30, 2014 | |||
===Early Placenta=== | ===Early Placenta=== | ||
Line 275: | Line 278: | ||
** can be "sampled" as part of a prenatal diagnostic test | ** can be "sampled" as part of a prenatal diagnostic test | ||
== | ===Week 3=== | ||
[[File:Stage7-sem4.jpg|right|300px]] | [[File:Stage7-sem4.jpg|right|300px]] | ||
* 3 Key processes commence | * 3 Key processes commence |
Revision as of 12:26, 9 April 2014
Embryology - 22 May 2024 Expand to Translate |
---|
Google Translate - select your language from the list shown below (this will open a new external page) |
العربية | català | 中文 | 中國傳統的 | français | Deutsche | עִברִית | हिंदी | bahasa Indonesia | italiano | 日本語 | 한국어 | မြန်မာ | Pilipino | Polskie | português | ਪੰਜਾਬੀ ਦੇ | Română | русский | Español | Swahili | Svensk | ไทย | Türkçe | اردو | ייִדיש | Tiếng Việt These external translations are automated and may not be accurate. (More? About Translations) |
Introduction
Human development is one of the most exciting topics to study not only as a medical student, but also for our fundamental understanding of the human body. Of all health issues in Medicine, fertility and reproduction is a topic that will affect everyone. This lecture is going to take you briefly through key biological concepts in human development, these will later be explored in more detail through the BGD course. I will be using simplified terms in the lecture slides (with developmental term in brackets).
- Australian Statistics 23 January 2014 at 03:02:40 PM (Canberra time), the resident population of Australia is projected to be: 23,360,679. (Similar sized countries - Mozambique, Syria, Madagascar, Romania, Australia, Cote d'Ivoire, Sri Lanka)
The lecture will be followed by a practical class introducing online resources for independent study and working through similar embryology concepts.
- Links: Printable Lecture Page | 2013 | 2012 | PDF version (873 KB, 6 pages)
Other Foundations links |
---|
The following lecture, practical and practical support pages for Foundations can be found on this current site.
|
Aims=
- Purpose of learning embryology
- Basic facts about early human development
- Appreciate differences between the conceptus, embryo and fetus
- General understanding of the term “critical periods” of development
Concepts: Fertilization, Early conceptus, Germ layers, Embryo, Tissue origins, Timetable/stages of development, Fetus, Placenta
Background Lectures: Cell Structure (structure and function), Cell Division (mitosis, meiosis, lifespan, cell death), 4 Basic Tissues (Epithelial, Connective, Muscular, Nervous)
Links: 2014 Practical | Embryology Textbooks
Four Basic Tissue Types
Tissues and organs of the body consist of combinations of 4 basic tissue organisations:
- Epithelial
- Connective
- Muscular
- Nervous
- Where do they come from?
- How do they develop?
Human Development Timeline
Last Menstrual Period (LMP) today -> Birth Date - January 30, 2014 |
---|
Gestation Calculation
|
Embryology Education Support
UNSW Embryology Online
<mediaplayer width='360' height='410' image="http://php.med.unsw.edu.au/embryology/images/6/61/Human_development_001_icon.jpg">File:Human development 001.mp4</mediaplayer> |
|
Using these resources (online navigation, organization and printing) will be covered in the introduction to the associated Practical class.
Glossary Links
- A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols
Textbooks
- There are many different excellent embryology textbooks
- I have included 2 that cover the clinical topics as well. More Textbooks?
- Links: More Embryology Textbooks
Human Reproductive Cycle
- Meiosis in gonad produces haploid gametes
- testis the sperm (spermatozoa)
- ovary the egg (oocyte)
- there are several differences in when and how gametes are formed in the male and female gonad.
Female
- Menstrual Cycle a regular cycle of reproduction (28 days)
- begins at puberty
- release of 1 egg (oocyte) every cycle
- Endocrine controlled (HPG axis)
- Hypothalamus
- Pituitary
- Gonad
Male
- begins at puberty
- continuous production of sperm (spermatozoa, human male 2,000/second)
- release millions of spermatozoa (require activation, capacitation)
Ovary
- Paired organs
- lying in the peritoneal cavity
Ovulation
- ovulation is the release of the egg (oocyte) at about the middle of the menstrual cycle
Human ovulation
Trimesters
- Divide the pregnancy into 3 "blocks" of about 3 months (trimesters)
- First Trimester - embryonic period (organogenesis)
- Second and Trimester - fetal period (growth)
First Trimester
- Embryonic Period - Week 1 to 8 (first trimester)
- Establish the basic structure of organs and tissues (Organogenesis)
- development and growth of the placenta (Placentation)
Fertilization
- the process of the 2 haploid gametes (egg and sperm) fusing and combining genetic material.
- conceptus - the entire product of fertilization
Week 1
- occurs freely floating in uterus
- occurs during week 1 following fertilization
- last menstrual period (LMP) week 3
- mitosis to form solid ball of cells (morula), then hollow ball (blastocyst)
Week 2
- Implantation - initial attachment to uterine wall, and then invasion of the uterine wall.
Abnormal Implantation
- Ectopic Sites
- external surface of uterus, ovary, bowel, gastrointestinal tract, mesentery, peritoneal wall
- If not spontaneous then, embryo has to be removed surgically
- Uterine - tubal pregnancy (most common ectopic)
Normal Implantation
- Uterine body
- posterior, anterior, superior, lateral (most common posterior)
- inferior implantation - placenta overlies internal os of uterus Placenta Previa
Detect Pregnancy
- Clinically can be detected following implantation (week 2)
- Last Menstrual Period (LMP) - today ? ....... Birth Date - January 30, 2014
Early Placenta
- interaction between implanting conceptus and uterine wall (endometrium)
- The uterine lining following implantation (Decidua)
- forms 3 distinct regions, at approx 3 weeks
- Decidua Basalis - implantation site
- Decidua Capsularis - enclosing the conceptus
- Decidua Parietalis - remainder of uterus
- uterine cavity is lost by 12 weeks
Placenta
- Materno/fetal organ
- No exchange of blood
- Many different roles
- can be "sampled" as part of a prenatal diagnostic test
Week 3
- 3 Key processes commence
1. Gastrulation
- the formation of the 3 layer embryo (trilaminar embryo)
- All tissues of the body are formed from these 3 embryonic tissue layers (germ layers)
- Ectoderm (epithelium)
- Mesoderm (connective tissue)
- Endoderm (epithelium)
- simplified explanation of the 3 layer contributions
Ectoderm
- forms the central and peripheral nervous system and epithelium of the skin
Endoderm
- forms gastrointestinal tract organs and the epithelium of the gastrointestinal and respiratory tracts
Mesoderm
- forms the body connective tissues: blood, bone, muscle, connective tissue skin, gastrointestinal and respiratory tracts
2. Somitogenesis
- segmentation of the mesoderm into somites
- forms the axial body plan
3. Neuralation
- segmentation of the ectoderm
- separates the neural tissue from the skin (epidermis)
Week 4
- heart formation (cardiogenesis)
- first functioning organ
Week 4-8
- early development of the other organs, tissues and limbs
Week 9 - 38
- Fetal Period - Second and Third Trimester
- Continuing growth and differentiation of organs formed in embryonic period
- some organs have a later development - neural, genital, respiratory, bones
- some continue to develop after birth - neural, genital, respiratory, bones
- growth in size, length (Second Trimester)
- growth in weight (Third Trimester)
Birth
- birth (parturition) is a complex physiological process between the fetus and mother
- thought to be initiated by the fetus
Maternal Birth Stages
- Dilatation
- Expulsion
- Placental
- Recovery
Australian Birth Rate 1998-2007
Newborn
Newborn (perinatal) needs to activate many systems and establish independent regulation (homeostasis)
- Lung function - Fluid drainage, Gas exchange, muscular activity
- Circulatory changes - Closure of 3 vascular shunts
- Thermoregulation - metabolic rate, fat metabolism
- Nutrition - gastrointestinal tract function, peristalsis
- Waste - kidney function
- Endocrine function - loss of placenta, maternal hormones
Critical Periods of Development
Abnormal Development
Three main causes:
- Genetic
- Environmental
- Unknown
- First trimester most critical
- Different effect depending on time of insult (teratogen)
Diagnosis
- Prenatal diagnosis - number of different techniques (non-invasive, invasive) for determining normal development
- Neonatal diagnosis (APGAR test, Guthrie test)
- Maternal diagnosis - often pregnancy will expose maternal health problems
- Gutherie card icon.jpg
Gutherie card
Revision Notes
- You don't need to know everything today, this is an introduction.
- Use the glossary to help understand new terms.
- Don't confuse "germ cell layers" (ectoderm, mesoderm, endoderm) with "germ cells" (egg, spermatazoa).
- Remember the difference between "clinical weeks" (last menstral period) and "embryonic weeks" (from ovulation/fertilisation, 2 weeks later).
- With abnormalities
- think about the types of prenatal dianostic techniques that are now available
- the 2 major types (genetic and environmental)
- the effect of maternal age/health/lifestyle.
Textbooks
Hill, M.A. (2013) UNSW Embryology (13th ed.). Sydney:UNSW.
| |
Keith L. Moore, T.V.N. Persaud, Mark G. Torchia. (2011). The Developing Human: clinically oriented embryology (9th ed.). Philadelphia: Saunders. | |
Schoenwolf, G.C., Bleyl, S.B., Brauer, P.R. and Francis-West, P.H. (2009). Larsen’s Human Embryology (4th ed.). New York; Edinburgh: Churchill Livingstone.
The following chapter links only work with a UNSW connection and can also be accessed through this UNSW Library connection. |
Foundations Practical - Introduction to Human Development
Glossary Links
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Cite this page: Hill, M.A. (2024, May 22) Embryology Foundations Lecture - Introduction to Human Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Foundations_Lecture_-_Introduction_to_Human_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G