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Extravillous Trophoblast (EVT)

Invasion in first trimester human placenta. EVTs originate from cell columns of anchoring villi. During the first trimester of pregnancy, EVTs invade into the decidual interstitium (1) reaching the inner third of the myometrium, thereby anchoring the placenta to the uterus. They also follow the (2) endovascular route of invasion, plug, line and remodel spiral arteries (2, red), thus being responsible for the establishment of the maternal–fetal blood flow starting with the beginning of the second trimester.

Prior to the opening of spiral arteries toward the intervillous space, maternal blood plasma is seeping through the trophoblastic plugs. Endovascular trophoblasts also reach and invade uterine veins and replace the venous endothelium (2, blue). Via the opened and dilated veins, maternal blood plasma and glandular secretion products are drained from the intervillous space into the maternal circulation. Endovascular trophoblasts invade and replace the tunica media of vessels, which in some cases leads to the fact that classification into artery or vein is no longer possible (2, red and blue). Endoglandular trophoblasts (3) are situated nearby uterine glands, replace the glandular epithelium and open the lumen of uterine glands toward the intervillous space.


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1883 Embryonic Membranes | 1907 Development Atlas | 1909 | 1910 Textbook | 1917 Textbook | 1921 Textbook | 1921 Foetal Membranes |1921 human | 1921 Pig implantation | 1922 Single placental artery | 1923 Placenta Review | 1939 umbilical cord | 1943 human and monkey | 1944 chorionic villus and decidua parietalis | 1946 placenta ageing | 1960 first trimester placenta | 1960 monkey | 1972 Placental circulation | Historic Disclaimer

Reference

<pubmed>27774579</pubmed>

Copyright

© The Author(s) 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Fig. 8 adjusted in size and labelled with PMID. Figure Scheme adapted from (Moser et al. 2015 PMID 26493408).



Cite this page: Hill, M.A. (2024, April 18) Embryology Extravillous trophoblast cartoon.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Extravillous_trophoblast_cartoon.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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current14:25, 5 June 2017Thumbnail for version as of 14:25, 5 June 20171,028 × 829 (249 KB)Z8600021 (talk | contribs)
14:24, 5 June 2017Thumbnail for version as of 14:24, 5 June 20172,092 × 1,805 (736 KB)Z8600021 (talk | contribs)Extravillous trophoblast (EVT)== Invasion in first trimester human placenta. EVTs originate from cell columns of anchoring villi. During the first trimester of pregnancy, EVTs invade into the decidual interstitium (1) reaching the inner third of the m...

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