2009 Lab 7
Muscle Development
Introduction
This laboratory will look at the musculoskeletal development. The laboratory will also allow time for work on the group online project.
Objectives
- Understand the origin, differentiation and development of skeletal muscle tissue.
- Know what is meant by patterning, conversion and adult plasticity of muscle fibre type.
- Develop an undestanding of research methods for studying fibre type control.
Lab Tutorial
Today's laboratory will begin with a tutorial presentation on muscle development and research into muscle disorders. During the presentation feel free to ask questions about any concepts you may not understand.
Slides: Muscle Development - Part 1 | Muscle Development - Part 2
Presentation Slides 4 / page (printing version): Muscle Development - Part 1 | Muscle Development - Part 1
Lab 7 Assessment Questions
Answer the questions shown below on your own student page.
- Briefly; what is a myotubeand how is it formed?
- What changes would I expect to see in the muscle fibre types in my legs if I:
- a) Suffered a spinal cord injury
- b) Took up marathon running
Questions are also shown listed on the Students Page Lab 7 Assessment
References - Dr Palmer
- Expression of Gtf2ird1, the Williams syndrome-associated gene, during mouse development. Palmer SJ, Tay ES, Santucci N, Cuc Bach TT, Hook J, Lemckert FA, Jamieson RV, Gunnning PW, Hardeman EC. Gene Expr Patterns. 2007 Feb;7(4):396-404. PMID: 17239664
- MusTRD can regulate postnatal fiber-specific expression. Issa LL, Palmer SJ, Guven KL, Santucci N, Hodgson VR, Popovic K, Joya JE, Hardeman EC. Dev Biol. 2006 May 1;293(1):104-15. PMID: 16494860
- hMusTRD1alpha1 represses MEF2 activation of the troponin I slow enhancer. Polly P, Haddadi LM, Issa LL, Subramaniam N, Palmer SJ, Tay ES, Hardeman EC. J Biol Chem. 2003 Sep 19;278(38):36603-10. PMID: 12857748
Search
- Bookshelf muscle development | muscle fiber type | troponin
- Pubmed muscle fiber type | troponin | Gtf2ird1 |
Links
- Blue Histology Skeletal Muscle histology
- Primer Skeletal Muscle Fiber Type: Influence on Contractile and Metabolic Properties
- Wiki Skeletal muscle | Troponin
- OMIM: Gtf2ird1
- OMIM: William-Beuren syndrome
Terms
Gtf2ird1 - General Transcription Factor 2 -I Repeat domain-containing protein 1
MusTRD1 - muscle TFII-I repeat domain-containing protein 1
Troponin - striated muscle contraction is regulated by the calcium-ion-sensitive, multiprotein complex troponin and the fibrous protein tropomyosin. Troponin has 3 subunits (TnC, TnI, TnT) and is located on the actin filament. OMIM: Troponin I slow
UNSW Embryology Links
- Musculoskeletal Development
- Muscle Development
- Development Timeline
- File:Muscle development 1-Talk1 muscle development.pdf
- File:Talk1 muscle development 4 per page.pdf
- File:Part 2 Muscle Development.pdf
- File:Part 2 Muscle Development 4 per page.pdf
Glossary Links
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Course Content 2009
Embryology Introduction | Cell Division/Fertilization | Cell Division/Fertilization | Week 1&2 Development | Week 3 Development | Lab 2 | Mesoderm Development | Ectoderm, Early Neural, Neural Crest | Lab 3 | Early Vascular Development | Placenta | Lab 4 | Endoderm, Early Gastrointestinal | Respiratory Development | Lab 5 | Head Development | Neural Crest Development | Lab 6 | Musculoskeletal Development | Limb Development | Lab 7 | Kidney | Genital | Lab 8 | Sensory - Ear | Integumentary | Lab 9 | Sensory - Eye | Endocrine | Lab 10 | Late Vascular Development | Fetal | Lab 11 | Birth, Postnatal | Revision | Lab 12 | Lecture Audio | Course Timetable
Cite this page: Hill, M.A. (2024, June 17) Embryology 2009 Lab 7. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/2009_Lab_7
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G