Jacob's syndrome

Embryology - 6 Oct 2026 Expand to Translate
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Educational Use Only - Embryology is an educational resource for learning concepts in embryological development, no clinical information is provided and content should not be used for any other purpose.

ICD-11
LD52.1 Male with double or multiple Y A condition affecting males, caused by the presence of supernumerary Y chromosomes. This condition is asymptomatic. Confirmation is through observation of supernumerary Y chromosomes by karyotyping.

Introduction

Jacob's syndrome (47 XYY syndrome, XYY syndrome) is a rare chromosomal disorder caused by the presence of an extra Y chromosome. Normally, males have 46 chromosomes including one X and one Y chromosome. Males with XYY syndrome have 47 chromosomes, two of which are Y chromosomes.

Some Recent Findings

Solid tumor screening recommendations in trisomy 18^[1] "The purpose of this study was to determine

More recent papers
This table allows an automated computer search of the external PubMed database using the listed "Search term" text link. This search now requires a manual link as the original PubMed extension has been disabled. The displayed list of references do not reflect any editorial selection of material based on content or relevance. References also appear on this list based upon the date of the actual page viewing. References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability. More? References \| Discussion Page \| Journal Searches \| 2019 References \| 2020 References Search term: Jacob's syndrome \| XYY syndrome

Glossary Links

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Cite this page: Hill, M.A. (2026, October 6) Embryology Jacob's syndrome. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Jacob%27s_syndrome

What Links Here?

↑ Farmakis SG, Barnes AM, Carey JC & Braddock SR. (2019). Solid tumor screening recommendations in trisomy 18. Am. J. Med. Genet. A , 179, 455-466. PMID: 30637956 DOI.

[PMID30637956-1] Farmakis SG, Barnes AM, Carey JC & Braddock SR. (2019). Solid tumor screening recommendations in trisomy 18. Am. J. Med. Genet. A , 179, 455-466. PMID: 30637956 DOI.

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