Sensory - Touch Development: Difference between revisions
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==Merkel cell== | ==Merkel cell== | ||
Merkel cells arise in the embryo<ref name=PMID25468937><pubmed>25468937</pubmed></ref> and in the adult<ref name=PMID25624394><pubmed>25624394</pubmed>| [http://jcb.rupress.org/content/208/3/367.long J Cell Biol.]</ref> from an epidermal progenitor cell population. These cells express the transcription factor Atoh1 and when differentiated are post-mitotic. | Merkel cells arise in the embryo<ref name=PMID25468937><pubmed>25468937</pubmed></ref> and in the adult<ref name=PMID25624394><pubmed>25624394</pubmed>| [http://jcb.rupress.org/content/208/3/367.long J Cell Biol.]</ref> from an epidermal progenitor cell population. These cells express the transcription factor Atoh1 and when differentiated are post-mitotic. | ||
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In the adult, abnormalities in Merkel cell development can lead to the rare disease of Merkel cell carcinoma (MCC). | |||
==Sensory Modalities== | ==Sensory Modalities== | ||
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==Abnormalities== | ==Abnormalities== | ||
Merkel cell carcinoma | * '''Merkel cell carcinoma''' (MCC) PMID 12007193 | ||
== References == | == References == | ||
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==External Links== | ==External Links== | ||
{{External Links}} | {{External Links}} | ||
* Merkel cell carcinoma - http://www.merkelcell.org | |||
Revision as of 15:47, 4 February 2015
Embryology - 16 Jun 2024 Expand to Translate |
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Introduction
These notes introduce the development of the sense of touch, part of the somatosensory system. Because of the distribution of the sensory structures within the skin, this topic is generally also covered in integumentary development.
Senses Links: Introduction | placode | Hearing and Balance hearing | balance | vision | smell | taste | touch | Stage 22 | Category:Sensory |
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Touch Development <pubmed limit=5>Touch Development</pubmed> |
Touch Receptors
Touch receptors in mammalian skin and the neural encoding of reception.[7]
Touch Pathway
Pacinian corpuscle
Meissner's corpuscle
Meissner's corpuscles are located throughout the skin and are seen concentrated in regions of high touch (finger tips, lips, genital regions).
Merkel cell
Merkel cells arise in the embryo[3] and in the adult[2] from an epidermal progenitor cell population. These cells express the transcription factor Atoh1 and when differentiated are post-mitotic.
Isolated Merkel cell (em) |
Merkel cell (Merkel-Ranvier cell) integumentary (skin) receptor cell connected with somatosensory afferents.
Cell characteristics a polylobulated nucleus and numerous typical dense-core granules in a clear cytoplasm. The name "Merckel cell" was based upon Friedrich Sigmund Merkel (1845 – 1919) a German anatomist and histologist, first description of these touch cells (Tastzellen) and named in his honour by Robert Bonnet (1851–1921). Scale bar 5 µm (Stain - Osmium) |
In the adult, abnormalities in Merkel cell development can lead to the rare disease of Merkel cell carcinoma (MCC).
Sensory Modalities
Thermoreceptors
- Receptors for heat (warmth) and cold (chill) detection.
- heat - C-fibres
- cold - Aδ fibres
Nociceptors
- Receptors for encoding and processing noxious stimuli.
- A-δ nociceptors
- Polymodal C-nociceptors
- C- mechano-insensitive nociceptors
Abnormalities
- Merkel cell carcinoma (MCC) PMID 12007193
References
- ↑ <pubmed>20956378</pubmed>| PMC2958478 | JCB
- ↑ 2.0 2.1 <pubmed>25624394</pubmed>| J Cell Biol.
- ↑ 3.0 3.1 <pubmed>25468937</pubmed>
- ↑ <pubmed>22710006</pubmed>
- ↑ <pubmed>21906948</pubmed>
- ↑ <pubmed>21041368</pubmed>
- ↑ <pubmed>20956378</pubmed>| PMC2958478 | JCB
Reviews
<pubmed>21841076</pubmed> <pubmed>20956378</pubmed>| JCB
Articles
Books
Neurobiology of Sensation and Reward. Gottfried JA, editor. Boca Raton (FL): CRC Press; 2011. Chapter 7 - Touch PMID 22593916
Search PubMed
Search Pubmed: Touch Development | touch receptors |
External Links
External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.
- Merkel cell carcinoma - http://www.merkelcell.org
Terms
- Georg Meissner - (1829-1905) German histologist, physiologist and anatomist. Beiträge zur Anatomie und Physiologie der Haut. (Contributions to the anatomy and physiology of the skin.) Leipzig, 1853.
- Friedrich Sigmund Merkel- (1845 – 1919) German anatomist and histologist, the name "Merckel cell" was based upon his first full description of touch cells (Tastzellen) and named by Robert Bonnet (1851–1921).
referred to these cells as Tastzellen or "touch cells" but this proposed function has been controversial as it has been hard to prove.
- Filippo Pacini - (1812-1883) Italian anatomist, published in 1840, and the name "Pacini's corpuscles" was proposed in 1844 by Henle and also by Kölliker.
- Angelo Ruffini (1864 – 1929) Italian histologist and embryologist, the name "Ruffini corpuscles" was based upon his first description of skin mechanoreceptors.
Glossary Links
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Cite this page: Hill, M.A. (2024, June 16) Embryology Sensory - Touch Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Sensory_-_Touch_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G