Endocrine - Gonad Development: Difference between revisions
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==Introduction== | ==Introduction== | ||
[[File:XXhpgaxis.jpg|thumb|Female HPG axis]] | [[File:XXhpgaxis.jpg|thumb|Female HPG axis]] | ||
The term gonad refers to both the female | The term gonad refers to both the female {{ovary}} and the male {{testis}}, both have their own detailed topic pages. This section of notes refers only to the development of the gonad as an endocrine organ. | ||
This section of notes refers only to the development of the gonad as an endocrine organ | |||
Embryonically, initial endocrine development of the testis is required for development of both the internal genital tract and the external genitalia. | Embryonically, initial endocrine development of the testis is required for development of both the internal genital tract and the external genitalia. | ||
Postnatally, the gonads are part of an integrated '''H'''ypothalamus-'''P'''ituitary-'''G'''onad (HPG) axis. | Postnatally, the gonads are part of an integrated '''H'''ypothalamus - '''P'''ituitary - '''G'''onad (HPG) axis. Post-puberty, this axis is the key regulator of the female reproductive cycle, the {{menstrual cycle}}. | ||
{{Endocrine Links}} | {{Endocrine Links}} | ||
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{{Menstrual_Links}} | |||
<br> | |||
{{Genital Links}} | |||
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== Some Recent Findings == | == Some Recent Findings == | ||
[[File:Model male androsterone synthesis.jpg|alt=Model male second trimester androsterone synthesis|thumb|Model male second trimester androsterone synthesis{{#pmid:30763313|PMID30763313}}]] | |||
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* '''Regulation of seminiferous tubule-associated stem Leydig cells in adult rat testes''' | * '''Transcriptional activity of oestrogen receptors in the course of embryo development'''{{#pmid:30012715|PMID30012715}} "Oestrogens are well-known proliferation and differentiation factors that play an essential role in the correct development of sex-related organs and behaviour in mammals. With the use of the ERE-Luc reporter mouse model, we show herein that throughout mouse development, oestrogen receptors (ERs) are active starting from day 12 post conception. Most interestingly, we show that prenatal luciferase expression in each organ is proportionally different in relation to the germ layer of the origin. The luciferase content is highest in ectoderm-derived organs (such as brain and skin) and is lowest in endoderm-derived organs (such as liver, lung, thymus and intestine). Consistent with the testosterone surge occurring in male mice at the end of pregnancy, in the first 2 days after birth, we observed a significant increase in the luciferase content in several organs, including the liver, bone, gonads and hindbrain. The results of the present study show a widespread transcriptional activity of ERs in developing embryos, pointing to the potential contribution of these receptors in the development of non-reproductive as well as reproductive organs. Consequently, the findings reported here might be relevant in explaining the significant differences in male and female physiopathology reported by a growing number of studies and may underline the necessity for more systematic analyses aimed at the identification of the prenatal effects of drugs interfering with ER signalling, such as aromatase inhibitors or endocrine disrupter chemicals." | ||
* '''Regulation of seminiferous tubule-associated stem Leydig cells in adult rat testes'''{{#pmid:26929346|PMID26929346}} "Testicular Leydig cells are the primary source of testosterone in males. Adult Leydig cells have been shown to arise from stem cells present in the neonatal testis. Once established, adult Leydig cells turn over only slowly during adult life, but when these cells are eliminated experimentally from the adult testis, new Leydig cells rapidly reappear. As in the neonatal testis, stem cells in the adult testis are presumed to be the source of the new Leydig cells. ... The proliferation of the stem Leydig cells was stimulated by paracrine factors including Desert hedgehog (DHH), basic fibroblast growth factor (FGF2), platelet-derived growth factor (PDGF), and activin. Suppression of proliferation occurred with transforming growth factor β (TGF-β). The differentiation of the stem cells was regulated positively by DHH, lithium- induced signaling, and activin, and negatively by TGF-β, PDGFBB, and FGF2. DHH functioned as a commitment factor, inducing the transition of stem cells to the progenitor stage and thus into the Leydig cell lineage." | |||
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! More recent papers | ! More recent papers | ||
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| [[File:Mark_Hill.jpg|90px|left]] {{Most_Recent_Refs}} | | [[File:Mark_Hill.jpg|90px|left]] {{Most_Recent_Refs}} | ||
Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Endocrine+Gonad+Development ''Endocrine Gonad Development''] | Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Endocrine+Gonad+Development ''Endocrine Gonad Development''] | [http://www.ncbi.nlm.nih.gov/pubmed/?term=Testosterone+Embryology ''Testosterone Embryology''] | [http://www.ncbi.nlm.nih.gov/pubmed/?term=Granulosa+Cell+Embryology ''Granulosa Cell Embryology''] | [http://www.ncbi.nlm.nih.gov/pubmed/?term=Leydig+Cell+Embryology ''Leydig Cell Embryology''] | [http://www.ncbi.nlm.nih.gov/pubmed/?term=Interstitial+Cell+Embryology ''Interstitial Cell Embryology''] | ||
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! Older papers | |||
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| {{Older papers}} | |||
* '''Fetal Testosterone (FT) Influences Sexually Dimorphic Gray Matter in the Human Brain'''{{#pmid:22238103|PMID22238103}} "These results bridge a long-standing gap between human and nonhuman species by showing that fetal testosterone acts as an organizing mechanism for the development of regional sexual dimorphism in the human brain." [[#Male Hormone Levels|Male Hormone Levels]] | [[Neural System Development]] | |||
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HPG Axis - [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=endocrin&part=A972&rendertype=box&id=A1057 Endocrinology - Simplified diagram of the actions of gonadotrophins] | HPG Axis - [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=endocrin&part=A972&rendertype=box&id=A1057 Endocrinology - Simplified diagram of the actions of gonadotrophins] | ||
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* X chromosome genes regulate ovary development | * X chromosome genes regulate ovary development | ||
== | ==Steroidogenesis== | ||
[[File:Steroidogenesis.png|600px|Steroidogenesis]] | |||
==Testosterone== | |||
Testicular Leydig cells (interstitial cells) are the main source of testosterone in males. | Testicular Leydig cells (interstitial cells) are the main source of testosterone in males. | ||
[[File:Male_testosterone_and_AMH_level_graph.jpg|600px]] | [[File:Male_testosterone_and_AMH_level_graph.jpg|600px]] | ||
Human Male Testosterone and Anti-Müllerian Hormone (AMH) relative levels | Human Male Testosterone and Anti-Müllerian Hormone (AMH) relative levels{{#pmid:16544032|PMID16544032}} | ||
===Leydig Cells=== | ===Leydig Cells=== | ||
[[File:Leydig cells stained for LHCGR1.jpg|400px]] | [[File:Leydig cells stained for LHCGR1.jpg|400px]] | ||
Leydig cells stained for LHCGR1 | Leydig cells stained for LHCGR1{{#pmid:18433292|PMID18433292}} | ||
== | ===Androgen and Digit ratio (2D:4D)=== | ||
[[File:Finger_length_ratio_-_2D4D.jpg|thumb|Androgen and Digit ratio (2D:4D]] | |||
The ratio of 2nd and 4th finger (D, digit) length. This ratio has been suggested to relate to high fetal [[T#testosterone|testosterone]] concentration (males have lower 2D:4D than females) and has been shown for several species.{{#pmid:16504142|PMID16504142}} Although a study in mice has not shown the same correlation.{{#pmid:19495421|PMID19495421}} There have been some suggestions that the ratio may also be an indicator of various neurological abnormalities. | |||
'''To measure (2D:4D)''' - using your right hand palm up, measure the index finger (2) and ring finger (4) length from palm to tip. Dividing the index finger by the ring finger gives the 2D:4D ratio, average women ratio is 1, average men is 0.98. | |||
==Anti-Mullerian Hormone== | |||
{{AMH}} | |||
==Estrogen== | |||
{| | |||
| The estradiol ({{estrogen}}, oestrogen) hormone is a steroid sex hormone expressed in both male and female. | |||
estrogenic activity in human placental extracts was due to the presence of at least three compounds: estriol, estrone, and 17β-estradiol. | |||
In the female, this hormone together with progesterone regulate changes that occur each menstrual cycle. During female development the fetal adrenal gland cortex synthesises DHEA (and DHEA/S), an oestrogen precursor (see image [[:File:Fetal adrenal gland steroidogenesis.jpg|Fetal adrenal gland steroidogenesis]]), converted by the {{placenta}} into estrogen compounds; estriol, estrone, and 17β-estradiol. During {{puberty}}, ovarian estrogen production is responsible for development of the secondary feminine sex characteristics. | |||
In the male, [[:File:Testis histology 2.jpg|Leydig cells]] produce estrogen into the rete testis fluid at variable levels in different species. During male embryonic development exposure to high levels of estrogen can lead to genital abnormalities. | |||
| [[File:Estradiol.jpg|alt=estrogen|300px]] | |||
Estradiol | |||
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==Progesterone== | |||
{| | |||
| The progesterone (progestin) hormone is produced by the granulosa cells of the ovarian follicles at different levels during the {{menstrual cycle}} and at high levels by the luteal cells (P4) of the {{corpus luteum}}. | |||
In 1934 progesterone (progestin) C<sub>21</sub>H<sub>30</sub>O<sub>2</sub> was first isolated from the {{corpus luteum}} and its structure reported by four separate groups of researchers.<ref name=Butenandt1934>Butenandt A. Neure Ergebnisse auf dem Gebiet der Sexualhormone. Wien Klin Wochenschr. 1934;47:936.</ref><ref name=Slotta1934>Slotta KH, Ruschig H, Fels E. Ȕber der Hormon aus dem Corpus-luteum. Ber Chem Ges. 1934;67:1270.</ref><ref name=Hartmann1934>Hartmann M, Wettstein A. Ein krystallisiertes Hormon aus Corpus-luteum. Helv Chim Acta. 1934;17:878.</ref>{{#pmid:17817057|PMID17817057}} | |||
| [[File:Progesterone.jpg|alt=Progesterone molecular structure|300px]] | |||
Progesterone molecular structure | |||
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{{Genital Links}} | |||
==Adult Histology== | ==Adult Histology== | ||
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==Additional Images== | ==Additional Images== | ||
{{ | {{Glossary}} | ||
{{ | {{Footer}} | ||
[[Category:Endocrine]] [[Category:Gonad]] | [[Category:Endocrine]] [[Category:Gonad]] |
Latest revision as of 13:22, 20 May 2019
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Introduction
The term gonad refers to both the female ovary and the male testis, both have their own detailed topic pages. This section of notes refers only to the development of the gonad as an endocrine organ.
Embryonically, initial endocrine development of the testis is required for development of both the internal genital tract and the external genitalia.
Postnatally, the gonads are part of an integrated Hypothalamus - Pituitary - Gonad (HPG) axis. Post-puberty, this axis is the key regulator of the female reproductive cycle, the menstrual cycle.
Menstrual Cycle Links: Introduction | menstrual histology | ovary | corpus luteum | oocyte | uterus | Uterine Gland | estrous cycle | pregnancy test | ||
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Genital Links: genital | Lecture - Medicine | Lecture - Science | Lecture Movie | Medicine - Practical | primordial germ cell | meiosis | endocrine gonad | Genital Movies | genital abnormalities | Assisted Reproductive Technology | puberty | Category:Genital
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Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Endocrine Gonad Development | Testosterone Embryology | Granulosa Cell Embryology | Leydig Cell Embryology | Interstitial Cell Embryology |
Older papers |
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These papers originally appeared in the Some Recent Findings table, but as that list grew in length have now been shuffled down to this collapsible table.
See also the Discussion Page for other references listed by year and References on this current page.
|
HPG Axis - Endocrinology - Simplified diagram of the actions of gonadotrophins
Gonad Development
- mesoderm - mesothelium and underlying mesenchyme, primordial germ cells
- Gonadal ridge - mesothelium thickening, medial mesonephros
- Primordial Germ cells - yolk sac, to mesentery of hindgut, to genital ridge of developing kidney
Differentiation
- testis-determining factor (TDF) from Y chromosome: presence (testes), absence (ovaries)
Testis
- 8 Weeks, mesenchyme, interstitial cells (of Leydig) secrete testosterone, androstenedione
- 8 to 12 Weeks - hCG stimulates testosterone production
- Sustentacular cells - produce anti-mullerian hormone to puberty
Ovary
- X chromosome genes regulate ovary development
Steroidogenesis
Testosterone
Testicular Leydig cells (interstitial cells) are the main source of testosterone in males.
Human Male Testosterone and Anti-Müllerian Hormone (AMH) relative levels[5]
Leydig Cells
Leydig cells stained for LHCGR1[6]
Androgen and Digit ratio (2D:4D)
The ratio of 2nd and 4th finger (D, digit) length. This ratio has been suggested to relate to high fetal testosterone concentration (males have lower 2D:4D than females) and has been shown for several species.[7] Although a study in mice has not shown the same correlation.[8] There have been some suggestions that the ratio may also be an indicator of various neurological abnormalities.
To measure (2D:4D) - using your right hand palm up, measure the index finger (2) and ring finger (4) length from palm to tip. Dividing the index finger by the ring finger gives the 2D:4D ratio, average women ratio is 1, average men is 0.98.
Anti-Mullerian Hormone
Estrogen
The estradiol (estrogen, oestrogen) hormone is a steroid sex hormone expressed in both male and female.
estrogenic activity in human placental extracts was due to the presence of at least three compounds: estriol, estrone, and 17β-estradiol. In the female, this hormone together with progesterone regulate changes that occur each menstrual cycle. During female development the fetal adrenal gland cortex synthesises DHEA (and DHEA/S), an oestrogen precursor (see image Fetal adrenal gland steroidogenesis), converted by the placenta into estrogen compounds; estriol, estrone, and 17β-estradiol. During puberty, ovarian estrogen production is responsible for development of the secondary feminine sex characteristics. In the male, Leydig cells produce estrogen into the rete testis fluid at variable levels in different species. During male embryonic development exposure to high levels of estrogen can lead to genital abnormalities. |
Estradiol |
Progesterone
The progesterone (progestin) hormone is produced by the granulosa cells of the ovarian follicles at different levels during the menstrual cycle and at high levels by the luteal cells (P4) of the corpus luteum.
|
Progesterone molecular structure |
Genital Links: genital | Lecture - Medicine | Lecture - Science | Lecture Movie | Medicine - Practical | primordial germ cell | meiosis | endocrine gonad | Genital Movies | genital abnormalities | Assisted Reproductive Technology | puberty | Category:Genital
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Adult Histology
References
- ↑ O'Shaughnessy PJ, Antignac JP, Le Bizec B, Morvan ML, Svechnikov K, Söder O, Savchuk I, Monteiro A, Soffientini U, Johnston ZC, Bellingham M, Hough D, Walker N, Filis P & Fowler PA. (2019). Alternative (backdoor) androgen production and masculinization in the human fetus. PLoS Biol. , 17, e3000002. PMID: 30763313 DOI.
- ↑ Della Torre S, Rando G, Meda C, Ciana P, Ottobrini L & Maggi A. (2018). Transcriptional activity of oestrogen receptors in the course of embryo development. J. Endocrinol. , 238, 165-176. PMID: 30012715 DOI.
- ↑ Li X, Wang Z, Jiang Z, Guo J, Zhang Y, Li C, Chung J, Folmer J, Liu J, Lian Q, Ge R, Zirkin BR & Chen H. (2016). Regulation of seminiferous tubule-associated stem Leydig cells in adult rat testes. Proc. Natl. Acad. Sci. U.S.A. , 113, 2666-71. PMID: 26929346 DOI.
- ↑ Lombardo MV, Ashwin E, Auyeung B, Chakrabarti B, Taylor K, Hackett G, Bullmore ET & Baron-Cohen S. (2012). Fetal testosterone influences sexually dimorphic gray matter in the human brain. J. Neurosci. , 32, 674-80. PMID: 22238103 DOI.
- ↑ Rey R. (2005). Anti-Müllerian hormone in disorders of sex determination and differentiation. Arq Bras Endocrinol Metabol , 49, 26-36. PMID: 16544032 DOI.
- ↑ Kossack N, Simoni M, Richter-Unruh A, Themmen AP & Gromoll J. (2008). Mutations in a novel, cryptic exon of the luteinizing hormone/chorionic gonadotropin receptor gene cause male pseudohermaphroditism. PLoS Med. , 5, e88. PMID: 18433292 DOI.
- ↑ McIntyre MH. (2006). The use of digit ratios as markers for perinatal androgen action. Reprod. Biol. Endocrinol. , 4, 10. PMID: 16504142 DOI.
- ↑ Yan RH, Bunning M, Wahlsten D & Hurd PL. (2009). Digit ratio (2Dratio4D) differences between 20 strains of inbred mice. PLoS ONE , 4, e5801. PMID: 19495421 DOI.
- ↑ Butenandt A. Neure Ergebnisse auf dem Gebiet der Sexualhormone. Wien Klin Wochenschr. 1934;47:936.
- ↑ Slotta KH, Ruschig H, Fels E. Ȕber der Hormon aus dem Corpus-luteum. Ber Chem Ges. 1934;67:1270.
- ↑ Hartmann M, Wettstein A. Ein krystallisiertes Hormon aus Corpus-luteum. Helv Chim Acta. 1934;17:878.
- ↑ Allen WM & Wintersteiner O. (1934). CRYSTALLINE PROGESTIN. Science , 80, 190-1. PMID: 17817057 DOI.
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Cite this page: Hill, M.A. (2024, June 15) Embryology Endocrine - Gonad Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Endocrine_-_Gonad_Development
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