Endocrine - Pancreas Development: Difference between revisions

Revision as of 14:07, 25 April 2010

Pancreas adult

pancreas structure

Historic Embryology - Endocrine
1903 Islets of Langerhans \| 1903 Pig Adrenal \| 1904 interstitial Cells \| 1908 Pancreas Different Species \| 1908 Pituitary \| 1908 Pituitary histology \| 1911 Rathke's pouch \| 1912 Suprarenal Bodies \| 1914 Suprarenal Organs \| 1915 Pharynx \| 1916 Thyroid \| 1918 Rabbit Hypophysis \| 1920 Adrenal \| 1935 Mammalian Hypophysis \| 1926 Human Hypophysis \| 1927 Adrenal \| 1927 Hypophyseal fossa \| 1930 Adrenal \| 1932 Pineal Gland and Cysts \| 1935 Hypophysis \| 1935 Pineal \| 1937 Pineal \| 1935 Parathyroid \| 1940 Adrenal \| 1941 Thyroid \| 1950 Thyroid Parathyroid Thymus \| 1957 Adrenal

Functions - exocrine (amylase, alpha-fetoprotein), 99% by volume; endocrine (pancreatic islets) 1% by volume
Exocrine function - begins after birth
Endocrine function - from 10 to 15 weeks onward hormone release
- exact roles of hormones in regulating fetal growth?

Pancreatic buds and duct developing

Stage22 pancreas

Pancreatic buds - duodenal level endoderm, splanchnic mesoderm forms dorsal and ventral mesentery, dorsal bud (larger, first), ventral bud (smaller, later)
Pancreas Endoderm - pancreas may be opposite of liver
- Heart cells promote/notochord prevents liver formation
- Notochord may promote pancreas formation
- Heart may block pancreas formation

Duodenum growth/rotation - brings ventral and dorsal buds together, fusion of buds
Pancreatic duct - ventral bud duct and distal part of dorsal bud, exocrine function
Islet cells - cords of endodermal cells form ducts, from which cells bud off to form islets

Islets of Langerhans - 4 endocrine cell types
Alpha - glucagon, mobilizes lipid
Beta - insulin, increase glucose uptake
- Beta cells, stimulate fetal growth, continue to proliferate to postnatal, in infancy most abundant
Delta - somatostatin, inhibits glucagon, insulin secretion
F-cells - pancreatic polypeptide

Week 7 to 20 - pancreatic hormones secretion increases, small amount maternal insulin
Week 10 - glucagon (alpha) differentiate first, somatostatin (delta), insulin (beta) cells differentiate, insulin secretion begins
Week 15 - glucagon detectable in fetal plasma

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Cite this page: Hill, M.A. (2024, June 16) Embryology Endocrine - Pancreas Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Endocrine_-_Pancreas_Development

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 ===Adult Histology===
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+File:Pancreatic islet.png|Pancreatic islet
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