Neural Crest - Schwann Cell Development

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Introduction

Schwann cells are glial cells that originate and development from neural crest cells migrating out along the developing nerve fibers. These cells differentiate to wrap around nerve axon processes to form myelin sheaths that improve nerve conduction. This process of myelination occurs also within the central nervous system by another population of glial cells. (More? gliogenesis)


Links: gliogenesis
Myelination animation.gif

Myelination

Historic Embryology
Theodor Schwann.jpg Schwann cells are named after Theodor Schwann (1810 - 1882) a German physiologist.


Neural Crest Links: neural crest | Lecture - Early Neural | Lecture - Neural Crest Development | Lecture Movie | Schwann cell | adrenal | melanocyte | peripheral nervous system | enteric nervous system | cornea | cranial nerve neural crest | head | skull | cardiac neural crest | Nicole Le Douarin | Neural Crest Movies | neural crest abnormalities | Category:Neural Crest
Historic Embryology - Neural Crest  
1879 Olfactory Organ | 1905 Cranial and Spinal Nerves | 1908 10 mm Peripheral | 1910 Mammal Sympathetic | 1920 Human Sympathetic | 1939 10 Somite Embryo | 1942 Origin | 1957 Adrenal

Some Recent Findings

  • Dual origin of enteric neurons in vagal Schwann cell precursors and the sympathetic neural crest[1] "Most of the enteric nervous system derives from the "vagal" neural crest, lying at the level of somites 1-7, which invades the digestive tract rostro-caudally from the foregut to the hindgut. Little is known about the initial phase of this colonization, which brings enteric precursors into the foregut. Here we show that the "vagal crest" subsumes two populations of enteric precursors with contrasted origins, initial modes of migration, and destinations. Crest cells adjacent to somites 1 and 2 produce Schwann cell precursors that colonize the vagus nerve, which in turn guides them into the esophagus and stomach. Crest cells adjacent to somites 3-7 belong to the crest streams contributing to sympathetic chains: they migrate ventrally, seed the sympathetic chains, and colonize the entire digestive tract thence. Accordingly, enteric ganglia, like sympathetic ones, are atrophic when deprived of signaling through the tyrosine kinase receptor ErbB3, while half of the esophageal ganglia require, like parasympathetic ones, the nerve-associated form of the ErbB3 ligand, Neuregulin-1. These dependencies might bear relevance to Hirschsprung disease, with which alleles of Neuregulin-1 are associated."
  • How Schwann Cells Sort Axons: New Concepts[2] "Peripheral nerves contain large myelinated and small unmyelinated (Remak) fibers that perform different functions. The choice to myelinate or not is dictated to Schwann cells by the axon itself, based on the amount of neuregulin I-type III exposed on its membrane. Peripheral axons are more important in determining the final myelination fate than central axons, and the implications for this difference in Schwann cells and oligodendrocytes are discussed. Interestingly, this choice is reversible during pathology, accounting for the remarkable plasticity of Schwann cells, and contributing to the regenerative potential of the peripheral nervous system. Radial sorting is the process by which Schwann cells choose larger axons to myelinate during development."
More recent papers  
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Search term: Schwann Cell Development | Peripheral Myelination Development

Older papers  
These papers originally appeared in the Some Recent Findings table, but as that list grew in length have now been shuffled down to this collapsible table.

See also the Discussion Page for other references listed by year and References on this current page.

  • Neural crest origin of olfactory ensheathing glia[3] "Olfactory ensheathing cells (OECs) are a unique class of glial cells with exceptional translational potential because of their ability to support axon regeneration in the central nervous system. Although OECs are similar in many ways to immature and nonmyelinating Schwann cells, and can myelinate large-diameter axons indistinguishably from myelination by Schwann cells, current dogma holds that OECs arise from the olfactory epithelium. Here, using fate-mapping techniques in chicken embryos and genetic lineage tracing in mice, we show that OECs in fact originate from the neural crest and hence share a common developmental heritage with Schwann cells."
  • Schwann cell precursors from nerve innervation are a cellular origin of melanocytes in skin[4] "Current opinion holds that pigment cells, melanocytes, are derived from neural crest cells produced at the dorsal neural tube and that migrate under the epidermis to populate all parts of the skin. Here, we identify growing nerves projecting throughout the body as a stem/progenitor niche containing Schwann cell precursors (SCPs) from which large numbers of skin melanocytes originate. SCPs arise as a result of lack of neuronal specification by Hmx1 homeobox gene function in the neural crest ventral migratory pathway. Schwann cell and melanocyte development share signaling molecules with both the glial and melanocyte cell fates intimately linked to nerve contact and regulated in an opposing manner by Neuregulin and soluble signals including insulin-like growth factor and platelet-derived growth factor. These results reveal SCPs as a cellular origin of melanocytes, and have broad implications on the molecular mechanisms regulating skin pigmentation during development, in health and pigmentation disorders."

Schwann cell myelination

Schwann cell myelination and dedifferentiation.jpg Schmidt-Lanterman cleft cartoon.jpg
Schwann cell myelination Schmidt-Lanterman cleft

Schwann and axon interactions.jpg

Mouse- spinal cord axons

Mouse- spinal cord axons.jpg

Mouse-sciatic nerve Schwann cell.jpg

References

  1. Espinosa-Medina I, Jevans B, Boismoreau F, Chettouh Z, Enomoto H, Müller T, Birchmeier C, Burns AJ & Brunet JF. (2017). Dual origin of enteric neurons in vagal Schwann cell precursors and the sympathetic neural crest. Proc. Natl. Acad. Sci. U.S.A. , 114, 11980-11985. PMID: 29078343 DOI.
  2. Feltri ML, Poitelon Y & Previtali SC. (2016). How Schwann Cells Sort Axons: New Concepts. Neuroscientist , 22, 252-65. PMID: 25686621 DOI.
  3. Barraud P, Seferiadis AA, Tyson LD, Zwart MF, Szabo-Rogers HL, Ruhrberg C, Liu KJ & Baker CV. (2010). Neural crest origin of olfactory ensheathing glia. Proc. Natl. Acad. Sci. U.S.A. , 107, 21040-5. PMID: 21078992 DOI.
  4. Adameyko I, Lallemend F, Aquino JB, Pereira JA, Topilko P, Müller T, Fritz N, Beljajeva A, Mochii M, Liste I, Usoskin D, Suter U, Birchmeier C & Ernfors P. (2009). Schwann cell precursors from nerve innervation are a cellular origin of melanocytes in skin. Cell , 139, 366-79. PMID: 19837037 DOI.

Reviews

Adameyko I & Lallemend F. (2010). Glial versus melanocyte cell fate choice: Schwann cell precursors as a cellular origin of melanocytes. Cell. Mol. Life Sci. , 67, 3037-55. PMID: 20454996 DOI.

Piaton G, Gould RM & Lubetzki C. (2010). Axon-oligodendrocyte interactions during developmental myelination, demyelination and repair. J. Neurochem. , 114, 1243-60. PMID: 20524961 DOI.

Chong SY & Chan JR. (2010). Tapping into the glial reservoir: cells committed to remaining uncommitted. J. Cell Biol. , 188, 305-12. PMID: 20142420 DOI.

Kaplan S, Odaci E, Unal B, Sahin B & Fornaro M. (2009). Chapter 2: Development of the peripheral nerve. Int. Rev. Neurobiol. , 87, 9-26. PMID: 19682631 DOI.

Articles

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Search Pubmed: Schwann Cell Development | Schwann Cell | Schwann Myelination Development

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Cite this page: Hill, M.A. (2019, June 25) Embryology Neural Crest - Schwann Cell Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Neural_Crest_-_Schwann_Cell_Development

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© Dr Mark Hill 2019, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G