Neural Crest - Melanocyte Development
|Embryology - 28 Apr 2017 Expand to Translate|
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Melanocytes provide the pigment melanin to keratinocytes in the skin epithelium. These cells are neural crest in origin and recent research suggests that skin melaocytes are derived from the same population that Schwann cells are derived. Schwann cells wrap around nerve axon processes outside of the central nervous system. These cells in development originate from neural crest cells migrating out along the developing nerve fibers and these cells differentiate to form myelin sheaths that surround the mature nerve. The cells are named after their original discoverer a German physiologist Theodor Schwann (1810 - 1882).
In mammals, these pigmented cells can also be found in other tissues such as the: eyes, ears, heart, and central nervous system meninges. Melanocyte cells are a key topic in medical research as they are the cell transformed in melanoma.
Some Recent Findings
|More recent papers|
This table shows an automated computer PubMed search using the listed sub-heading term.
References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.
Nobuko Yamada-Goto, Yukari Ochi, Goro Katsuura, Yui Yamashita, Ken Ebihara, Michio Noguchi, Junji Fujikura, Daisuke Taura, Masakatsu Sone, Kiminori Hosoda, Paul E Gottschall, Kazuwa Nakao Neuronal cells derived from human induced pluripotent stem cells as a functional tool of melanocortin system. Neuropeptides: 2017; PubMed 28434791
Kirsten C Webb, Magdalena Harasimowicz, Monica Janeczek, Jodi Speiser, James Swan, Rebecca Tung Development of Asymmetric Facial Depigmentation in a Patient Treated with Dasatinib with New-Onset Hypovitaminosis D: Case Report and Review of the Literature. Case Rep Dermatol Med: 2017, 2017;9359086 PubMed 28424749
Carmen Cerchia, Antonio Lavecchia Small Molecule Drugs And Targeted Therapy For Melanoma: Current Strategies And Future Directions. Curr. Med. Chem.: 2017; PubMed 28413965
Deping Han, Yuanyuan Zhang, Jianfei Chen, Guoying Hua, Junying Li, Xuegong Deng, Xuemei Deng Transcriptome analyses of differential gene expression in the bursa of Fabricius between Silky Fowl and White Leghorn. Sci Rep: 2017, 7;45959 PubMed 28406147
Eun Young Seo, Seon-Pil Jin, Kyung-Cheol Sohn, Chi-Hyun Park, Dong Hun Lee, Jin Ho Chung UCHL1 Regulates Melanogenesis through Controlling MITF Stability in Human Melanocytes. J. Invest. Dermatol.: 2017; PubMed 28392346
Overview of Melanocyte Development in Mammals and Zebrafish
(pl., ephilides; freckle) Clinical term describing a "freckle", that is a small brown or tan mark on the skin. These inherited features result from a copy of variant Melanocortin 1 Receptor (MC1R) gene and are common on fair skinned Celtic children. Melanocytes produce locally more melanin, this can also increase following exposure to ultraviolet radiation in sunlight.
- Links: OMIM MC1R
(French, cafe-au-lait = coffee with milk; café-au-lait macule; birthmark) describes the characteristic colour of the hyperpigmented skin patch. The common name (birthmark) reflects the presence at birth (congenital) or appearing in early infancy. The pigment is produced locally by melanocytes, that produce all skin pigmentation.
Appear commonly as a solitary feature, multiple café-au-lait macules are associated with various genetic syndromes including Neurofibromatosis type 1 and 2.
- Links: OMIM - NF1
Developing mouse ((bt9J/bt9J) melanoblast distribution in whole mount and trunk detail (green - β-galactosidase stained).
Mouse Melanoblast Migration
See also Modeling melanoblast development 
- Links: Neural Crest Development
Erbb3b gene is required to establish melanocyte stem cells in the embryo that are responsible for regenerating melanocytes after melanocytes are ablated in the larval zebrafish. Because this adult stem cell is not required for the development of embryonic melanocytes, we conclude that adult melanocyte stem cells develop in parallel to the embryonic tissues that they regulate.
- Debra L Silver, Ling Hou, Robert Somerville, Mary E Young, Suneel S Apte, William J Pavan The secreted metalloprotease ADAMTS20 is required for melanoblast survival. PLoS Genet.: 2008, 4(2);e1000003 PubMed 18454205 | PLoS Genet.
- Debra L Silver, Karen E Leeds, Hun-Way Hwang, Emily E Miller, William J Pavan The EJC component Magoh regulates proliferation and expansion of neural crest-derived melanocytes. Dev. Biol.: 2013, 375(2);172-81 PubMed 23333945
- Shigeki Ohta, Yoichi Imaizumi, Yohei Okada, Wado Akamatsu, Reiko Kuwahara, Manabu Ohyama, Masayuki Amagai, Yumi Matsuzaki, Shinya Yamanaka, Hideyuki Okano, Yutaka Kawakami Generation of human melanocytes from induced pluripotent stem cells. PLoS ONE: 2011, 6(1);e16182 PubMed 21249204 | PMC3020956 | PLoS One
- Igor Adameyko, Francois Lallemend, Jorge B Aquino, Jorge A Pereira, Piotr Topilko, Thomas Müller, Nicolas Fritz, Anna Beljajeva, Makoto Mochii, Isabel Liste, Dmitry Usoskin, Ueli Suter, Carmen Birchmeier, Patrik Ernfors Schwann cell precursors from nerve innervation are a cellular origin of melanocytes in skin. Cell: 2009, 139(2);366-79 PubMed 19837037
- Richard L Mort, Ian J Jackson, E Elizabeth Patton The melanocyte lineage in development and disease. Development: 2015, 142(4);620-632 PubMed 25670789 | Development
- Lionel Larue, Florian de Vuyst, Véronique Delmas Modeling melanoblast development. Cell. Mol. Life Sci.: 2013, 70(6);1067-79 PubMed 22915137
- Keith A Hultman, Erine H Budi, Daniel C Teasley, Andrew Y Gottlieb, David M Parichy, Stephen L Johnson Defects in ErbB-dependent establishment of adult melanocyte stem cells reveal independent origins for embryonic and regeneration melanocytes. PLoS Genet.: 2009, 5(7);e1000544 PubMed 19578401 | PMC2699538 | PLoS Genet.
Lukas Sommer Generation of melanocytes from neural crest cells. Pigment Cell Melanoma Res: 2011, 24(3);411-21 PubMed 21310010
Melissa L Harris, Laura L Baxter, Stacie K Loftus, William J Pavan Sox proteins in melanocyte development and melanoma. Pigment Cell Melanoma Res: 2010, 23(4);496-513 PubMed 20444197
Patrik Ernfors Cellular origin and developmental mechanisms during the formation of skin melanocytes. Exp. Cell Res.: 2010, 316(8);1397-407 PubMed 20211169
Cynthia D Cooper, David W Raible Mechanisms for reaching the differentiated state: Insights from neural crest-derived melanocytes. Semin. Cell Dev. Biol.: 2009, 20(1);105-10 PubMed 18935965
Yulin Li, Xuping Zhu, Liu Yang, Junying Li, Zhengxing Lian, Ning Li, Xuemei Deng Expression and network analysis of genes related to melanocyte development in the Silky Fowl and White Leghorn embryos. Mol. Biol. Rep.: 2011, 38(2);1433-41 PubMed 20848220
C Claus Stolt, Petra Lommes, Simone Hillgärtner, Michael Wegner The transcription factor Sox5 modulates Sox10 function during melanocyte development. Nucleic Acids Res.: 2008, 36(17);5427-40 PubMed 18703590
Carmit Levy, Mehdi Khaled, David E Fisher MITF: master regulator of melanocyte development and melanoma oncogene. Trends Mol Med: 2006, 12(9);406-14 PubMed 16899407
Search Dec 2010 "Melanocyte Development" All (2294) Review (443) Free Full Text (704)
Search Pubmed: Melanocyte Development
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- Bennett-Sviderskaya Laboratory
- The Wistar Institute - Melanoma Research
- Hoerter Research Lab - Zebrafish Model for Melanoma
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Cite this page: Hill, M.A. 2017 Embryology Neural Crest - Melanocyte Development. Retrieved April 28, 2017, from https://embryology.med.unsw.edu.au/embryology/index.php/Neural_Crest_-_Melanocyte_Development
- © Dr Mark Hill 2017, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G