Gastrointestinal Tract - Gallbladder Histology

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Introduction

Gallbladder transverse section historic drawing.

This section of notes gives an overview mainly of adult gallbladder histology. Note that the term "gall bladder" can also be used for this organ.

HMsmall.jpg

Page also provides further background information for Medicine phase 1 Health Maintenance B Hepatobiliary System 2 Practical Virtual Slides. This page content is not part of the HMB practical class.


HMB: Pancreas Histology | Liver Histology | Gallbladder Histology | Renal System Histology


GIT Links: Introduction | Medicine Lecture | Science Lecture | endoderm | mouth | oesophagus | stomach | liver | gallbladder | Pancreas | intestine | mesentery | tongue | taste | enteric nervous system | Stage 13 | Stage 22 | gastrointestinal abnormalities | Movies | Postnatal | milk | tooth | salivary gland | BGD Lecture | BGD Practical | GIT Terms | Category:Gastrointestinal Tract
GIT Histology Links: Upper GIT | Salivary Gland | Smooth Muscle Histology | Liver | Gallbladder | Pancreas | Colon | Histology Stains | Histology | GIT Development
Historic Embryology - Gastrointestinal Tract  
1878 Alimentary Canal | 1882 The Organs of the Inner Germ-Layer The Alimentary Tube with its Appended Organs | 1884 Great omentum and transverse mesocolon | 1902 Meckel's diverticulum | 1902 The Organs of Digestion | 1903 Submaxillary Gland | 1906 Liver | 1907 Development of the Digestive System | 1907 Atlas | 1907 23 Somite Embryo | 1908 Liver | 1908 Liver and Vascular | 1910 Mucous membrane Oesophagus to Small Intestine | 1910 Large intestine and Vermiform process | 1911-13 Intestine and Peritoneum - Part 1 | Part 2 | Part 3 | Part 5 | Part 6 | 1912 Digestive Tract | 1912 Stomach | 1914 Digestive Tract | 1914 Intestines | 1914 Rectum | 1915 Pharynx | 1915 Intestinal Rotation | 1917 Entodermal Canal | 1918 Anatomy | 1921 Alimentary Tube | 1932 Gall Bladder | 1939 Alimentary Canal Looping | 1940 Duodenum anomalies | 2008 Liver | 2016 GIT Notes | Historic Disclaimer
Human Embryo: 1908 13-14 Somite Embryo | 1921 Liver Suspensory Ligament | 1926 22 Somite Embryo | 1907 23 Somite Embryo | 1937 25 Somite Embryo | 1914 27 Somite Embryo | 1914 Week 7 Embryo
Animal Development: 1913 Chicken | 1951 Frog

Lab Audio

Podcast icon.jpg Wednesday 24 August 2011 3-3:30 pm G2G4.


Links: listen 1 | download 1 | listen 2 | download 2 | listen 3 | download 3 | listen 4 | download 4 | Gall Bladder Histology Background


Gallbladder Structure

Anatomy

  • Pear-shaped
  • distensible sac (about 50ml volume)
  • Attached to posterioinferior surface of liver
  • Embryonic - foregut, forms from primitive bile duct
  • leads to cystic duct
    • Liver -> hepatic duct
    • Gallbladder -> cystic duct
    • Common Bile duct


Macroscopic Mucosal features:

  • Mucosa (epithelium + lamina propria)
    • Mucosal folds
    • Rokitansky-Aschoff sinuses
  • Serosa/Adventitia (dense CT + visceral mesothelium)

Epithelium

  • Columnar epithelium with microvilli (absorptive epithelium)
    • Epithelium lining the biliary system does not contain mucus-producing cells (few located in neck of gall bladder)
  • Basement membrane (not basal lamina which forms part of basement membrane and only visible by EM)

Lamina Propria

  • connective tissue
  • collagen fibers and fibroblasts
  • fenestrated capillaries and venules
  • lymphocytes and plasma cells

Smooth Muscle Layer

  • random orientation of smooth muscle cells (fibers)
  • muscularis propria (or fibromuscular coat)[1]
    • not like the rest of GIT smooth muscle organisation, which is divided into muscularis mucosa (inside submucosa), muscularis externa (circular and longitudinal)
    • various terminology used for this layer in different sources

Serosa/Adventitia

  • Dense connective tissue layer covered with visceral mesothelium epithelial layer
    • Adventitia - where it is attached to the liver
    • Serosa - where it is free in the peritoneum
  • Large blood vessels (arteries, veins)
  • Obvious lymphatic vessels
  • Autonomic nerve bundles
  • Adipose tissue

Gall Bladder Function

  • bile storage
  • bile concentration
  • bile release

Histology Images

Development Histology

Adult Histology

Gall bladder histology 001.jpg Gall bladder histology 002.jpg

Gall bladder histology 003.jpg Gall bladder histology 004.jpg


See also Animated labeled image

References

  1. Raparia K, Zhai QJ, Schwartz MR, Shen SS, Ayala AG & Ro JY. (2010). Muscularis mucosae versus muscularis propria in gallbladder, cystic duct, and common bile duct: smoothelin and desmin immunohistochemical study. Ann Diagn Pathol , 14, 408-12. PMID: 21074688 DOI.

Historic

Embryology Historic Terminology

  • Luschka ducts (duct of Luschka) is historic term referring to an accessory bile duct.
  • folds of Heister (spiral valves of Heister) are undulating folds containing muscle fibers in the proximal mucosa of the cystic duct. First described by Heister in 1732. PMID: 15696536

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Cite this page: Hill, M.A. (2024, March 19) Embryology Gastrointestinal Tract - Gallbladder Histology. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Gastrointestinal_Tract_-_Gallbladder_Histology

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G