Endoderm

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Introduction

The trilaminar embryo

The bottom germ layer of the early trilaminar embryo germ layers (ectoderm, mesoderm and endoderm) formed by gastrulation.


The endoderm contributes the epithelia and glands of the gastrointestinal tract, respiratory tract and the renal bladder. This layer also contributes to the associated gastrointestinal tract organ development (liver and pancreas).

The layer appears to initially be influenced by the overlying notochord and subsequently by a range of growth factors regulating growth and differentiation.

Note that this layer also lines the extra-embryonic yolk sac and allantois, which are initially continuous with the intra-embryonic endoderm.


Endoderm cartoon.jpg

Endoderm Links: Endoderm | Mesoderm | Ectoderm | Lecture - Endoderm, Early Gastrointestinal | Lecture - Respiratory Development | Gastrointestinal Tract Development | Respiratory System Development | Category:Endoderm

Some Recent Findings

  • Late stage definitive endodermal differentiation can be defined by Daf1 expression[1] "Definitive endoderm (DE) gives rise to the respiratory apparatus and digestive tract. Sox17 and Cxcr4 are useful markers of the DE. Previously, we identified a novel DE marker, Decay accelerating factor 1(Daf1/CD55), by identifying DE specific genes from the expression profile of DE derived from mouse embryonic stem cells (ESCs) by microarray analysis, and in situ hybridization of early embryos. Daf1 is expressed in a subpopulation of E-cadherin + Cxcr4+ DE cells. The characteristics of the Daf1-expressing cells during DE differentiation has not been examined. ...Daf1-expressing late definitive endoderm proliferates slowly and show low adhesive capacity." OMIM Daf1
  • Role of the gut endoderm in relaying left-right patterning in mice[2] "Establishment of left-right (LR) asymmetry occurs after gastrulation commences and utilizes a conserved cascade of events. In the mouse, LR symmetry is broken at a midline structure, the node, and involves signal relay to the lateral plate, where it results in asymmetric organ morphogenesis. How information transmits from the node to the distantly situated lateral plate remains unclear. ... Collectively, our data demonstrate that Cx43-mediated communication across gap junctions within the gut endoderm serves as a mechanism for information relay between node and lateral plate in a process that is critical for the establishment of LR asymmetry in mice."
  • Endoderm Review[3] "The endoderm germ layer contributes to the respiratory and gastrointestinal tracts and to all of their associated organs. Over the past decade, studies in vertebrate model organisms, including frog, fish, chick, and mouse, have greatly enhanced our understanding of the molecular basis of endoderm organ development. "
More recent papers  
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This table shows an automated computer PubMed search using the listed sub-heading term.

  • Therefore the list of references do not reflect any editorial selection of material based on content or relevance.
  • References appear in this list based upon the date of the actual page viewing.

References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.

Links: References | Discussion Page | Pubmed Most Recent | Journal Searches


Search term: Endoderm Development | Images

Karl Palmquist, Brad Davidson Establishment of lateral organ asymmetries in the invertebrate chordate, Ciona intestinalis. Evodevo: 2017, 8;12 PubMed 28770040

Marc D Servetnick, Bailey Steinworth, Leslie S Babonis, David Simmons, Miguel Salinas-Saavedra, Mark Q Martindale Cas9-mediated excision of Nematostella brachyury disrupts endoderm development, pharynx formation, and oral-aboral patterning. Development: 2017; PubMed 28705897

Gang Zhai, Jia Song, Tingting Shu, Junjun Yan, Xia Jin, Jiangyan He, Zhan Yin LRH-1 senses signaling from phosphatidylcholine to regulate the expansion growth of digestive organs via synergy with Wnt/β-catenin signaling in zebrafish. J Genet Genomics: 2017; PubMed 28642062

Changfu Yao, Gianni Carraro, Bindu Konda, Xiangrong Guan, Takako Mizuno, Norika Chiba, Matthew Kostelny, Adrianne Kurkciyan, Gregory David, Jonathan L McQualter, Barry R Stripp Sin3a regulates epithelial progenitor cell fate during lung development. Development: 2017; PubMed 28619823

J B Fisher, K Pulakanti, S Rao, S A Duncan GATA6 is essential for endoderm formation from human pluripotent stem cells. Biol Open: 2017; PubMed 28606935

Early Endoderm Cartoon

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This animation shows the early development of endoderm forming the gastrointestinal tract, yolk sac and allantois. The movie starts approximately week 3 and continues through week 4.

Yellow shows the general lining of the yolk sac (bottom), continuous with the endoderm of the trilaminar embryonic disc (top) during week 3. As the trilaminar disc folds in this week, the foregut and hindgut regions become separated from the external yolk sac. The midgut region remains open to the yolk sac and will separate later.

Foregut - Begins at the buccopharyngeal membrane, the foregut region in the head is now called the pharynx. At the lower end of the pharynx a ventral bud forms, that will later form the respiratory tract. Beneath this region the tube grows rapidly forming a dilation of the tube, that will later form the stomach. Beneath this region is the boundary of the foregut and ventrally lies the transverse septum.

Midgut - Broadly open to the external yolk sac then with continued folding narrows to a "tube-like" connection the yolk stalk. This stalk will later degenerate and all connection will normally be lost. The yolk sac is pushed to the periphery by the growing amniotic sac, with its connecting yolk stalk in the umbilicus region. The midgut region also grows in length forming a loop lying outside the ventral body wall.

Hindgut - The loop of midgut renters the body and the ventral portion of the hindgut extends as a blind-ended tube, or diverticulum, into the connecting stalk. This endoderm extension can be seen in histological sections of the initial placental cord and is called the allantois. The hindgut extends caudal (tailward) ending at the cloacal membrane.

Endoderm 002 icon.jpg
 ‎‎Endoderm
Page | Play

Hypochord

The hypochord (subnotochordal rod) is a transient endoderm structure found in the amphibian and fish embryo.[4] It forms a rod-like structure from a single row of cells lying immediately ventral to the notochord. The region is though to play a role in patterning the development of the dorsal aorta and degenerates by apoptosis.

It was first identified in the late 1900's:

  • Stöhr, Ph. (1895). Ueber die Entwickelung der Hypochorda und des dorsalen Pankreas bei Rana temporaria. Morph. Jahrb. Bd. 23, 123-141.
  • Bergfeldt, A. (1896). Chordascheiden und Hypochorda bei Alytes obstericans. Anat Hefte Bd. 7, 55-102.
  • Klaatsch, H., (1898). Zur Frage nach der morphologiscrn Bedeutung der Hypochorda. Morphol. Jahrb. 25, 156-169.
Links: Frog Development | Zebrafish Development

Molecular

Embryo left-right asymmetry pathway
Embryo left-right asymmetry pathway[5]

Markers

Several studies have identified the following proteins as markers for endoderm in different species.

  • Foxa2 - Forkhead box A2 expressed by anterior primitive streak that forms endoderm.[6] OMIM FOXA2
  • Sox17 - Sry-Related HMG-Box gene 17 Sox | OMiM - SOX17
  • Cxcr4 - Chemokine, Cxc Motif, Receptor 4 a membrane receptor for neuropeptide Y OMIM CXCR4
  • Daf1 - Decay-Accelerating Factor for complement.[1] OMIM DAF1

Nodal

  • signaling pathway initiates endoderm and mesoderm development
  • also required for proper gastrulation and axial patterning.
  • ligands are members of the TGFβ family of secreted growth factors.
  • promotes the expression of a network of transcription factors Mix-like proteins (Foxa2, Sox17, Eomesodermin, and Gata4–6).


Links: TGF-beta | Molecular Development

Patterning

  • foregut - (anterior) Hhex, Sox2, and Foxa2 transcription factors.
  • hindgut - (posterior) also positioning of the foregut-hindgut boundary, homeobox genes Cdx1, 2, and 4.[7]


Chicken antero-posterior endoderm patterning cartoon

Chicken antero-posterior endoderm patterning<ref name=PMID19516907<pubmed>19516907</pubmed>| PLoS One.<ref>


References

  1. 1.0 1.1 Soichiro Ogaki, Hisayoshi Omori, Mayu Morooka, Nobuaki Shiraki, Seiichi Ishida, Shoen Kume Late stage definitive endodermal differentiation can be defined by Daf1 expression. BMC Dev. Biol.: 2016, 16(1);19 PubMed 27245320
  2. Manuel Viotti, Lei Niu, Song-Hai Shi, Anna-Katerina Hadjantonakis Role of the gut endoderm in relaying left-right patterning in mice. PLoS Biol.: 2012, 10(3);e1001276 PubMed 22412348
  3. Aaron M Zorn, James M Wells Vertebrate endoderm development and organ formation. Annu. Rev. Cell Dev. Biol.: 2009, 25;221-51 PubMed 19575677
  4. O Cleaver, D W Seufert, P A Krieg Endoderm patterning by the notochord: development of the hypochord in Xenopus. Development: 2000, 127(4);869-79 PubMed 10648245
  5. Dominic P Norris Cilia, calcium and the basis of left-right asymmetry. BMC Biol.: 2012, 10;102 PubMed 23256866 | BMC Biology
  6. Ingo Burtscher, Heiko Lickert Foxa2 regulates polarity and epithelialization in the endoderm germ layer of the mouse embryo. Development: 2009, 136(6);1029-38 PubMed 19234065
  7. Kallayanee Chawengsaksophak, Wim de Graaff, Janet Rossant, Jacqueline Deschamps, Felix Beck Cdx2 is essential for axial elongation in mouse development. Proc. Natl. Acad. Sci. U.S.A.: 2004, 101(20);7641-5 PubMed 15136723

Reviews

Aaron M Zorn, James M Wells Vertebrate endoderm development and organ formation. Annu. Rev. Cell Dev. Biol.: 2009, 25;221-51 PubMed 19575677

Aaron M Zorn, James M Wells Molecular basis of vertebrate endoderm development. Int. Rev. Cytol.: 2007, 259;49-111 PubMed 17425939

Samara L Lewis, Patrick P L Tam Definitive endoderm of the mouse embryo: formation, cell fates, and morphogenetic function. Dev. Dyn.: 2006, 235(9);2315-29 PubMed 16752393

A Grapin-Botton, D A Melton Endoderm development: from patterning to organogenesis. Trends Genet.: 2000, 16(3);124-30 PubMed 10689353

J M Wells, D A Melton Vertebrate endoderm development. Annu. Rev. Cell Dev. Biol.: 1999, 15;393-410 PubMed 10611967


Articles

Elke Bayha, Mette C Jørgensen, Palle Serup, Anne Grapin-Botton Retinoic acid signaling organizes endodermal organ specification along the entire antero-posterior axis. PLoS ONE: 2009, 4(6);e5845 PubMed 19516907


Historic

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Cite this page: Hill, M.A. 2017 Embryology Endoderm. Retrieved November 18, 2017, from https://embryology.med.unsw.edu.au/embryology/index.php/Endoderm

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© Dr Mark Hill 2017, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G