Birth - Macrosomia
|Embryology - 25 Sep 2017 Expand to Translate|
|Google Translate - select your language from the list shown below (this will open a new external page)|
العربية | català | 中文 | 中國傳統的 | français | Deutsche | עִברִית | हिंदी | bahasa Indonesia | italiano | 日本語 | 한국어 | မြန်မာ | Pilipino | Polskie | português | ਪੰਜਾਬੀ ਦੇ | Română | русский | Español | Swahili | Svensk | ไทย | Türkçe | اردو | ייִדיש | Tiếng Việt These external translations are automated and may not be accurate. (More? About Translations)
Macrosomia (large gestational age, LGA) is a term used to describe a newborn with an excessive birth weight due to a range of known and unknown causes. There are many different definitions that have been used for to this term, generally a birth weight of 4000 to 4500 g (8 lb 13 oz to 9 lb 15 oz) or greater than 90% for gestational age after correcting for neonatal sex and ethnicity.
A recent study of USA data suggests adverse perinatal outcomes of birthweight exceeded the 97th percentile. Their definition was a "birthweight greater than 4500 g in Whites, or 4300 g in Blacks and Hispanics regardless of gestational age is the optimal threshold to define macrosomia. A birthweight greater than the 97th percentile for a given gestational age, irrespective of race is also reasonable to define macrosomia."
- Duration of gestation - growth past the due date.
- Maternal diabetes - presence of gestational diabetes; and class A, B, and C diabetes mellitus.
- Genetic Syndromes and Tumours - a range of overgrowth syndromes associated with developmental delay, tumors, and other anomalies with genetic causes and syndromes (Pallister-Killian, Beckwith-Wiedemann, Sotos, Perlman, and Simpson-Golabi-Behmel) rarely diagnosed prenatally.
Currently there is clinical research looking into the best mathematical formula, based upon ultrasound measurements, to estimate the possibility of macrosomia occurring.
- Birth Links: Introduction | Lecture - Birth | Caesarean | Preterm | Birth Weight | Birth Statistics | Australian Birth Data | Developmental Origins of Health and Disease | Macrosomia | Neonatal Diagnosis | Apgar test | Guthrie test | Neonatal Development | Stillbirth and Perinatal Death | ICD-10 Perinatal Period | Category:Birth | Maternal Diabetes
Some Recent Findings
|More recent papers|
This table shows an automated computer PubMed search using the listed sub-heading term.
References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.
Ritsuko Kawaharada, Haruna Masuda, Zhenyi Chen, Eric Blough, Tomoko Kohama, Akio Nakamura Intrauterine hyperglycemia-induced inflammatory signalling via the receptor for advanced glycation end products in the cardiac muscle of the infants of diabetic mother rats. Eur J Nutr: 2017; PubMed 28942514
Cornelia J J M Caron, Britt I Pluijmers, Eppo B Wolvius, Caspar W N Looman, Neil Bulstrode, Robert D Evans, Peter Ayliffe, John B Mulliken, David Dunaway, Bonnie Padwa, Maarten J Koudstaal Erratum to "Craniofacial and extracraniofacial anomalies in craniofacial macrosomia: A multicenter study of 755 patients" [J Craniomaxillofac Surg vol. 45(8) (August 2017), 1302-1310]. J Craniomaxillofac Surg: 2017; PubMed 28935485
Hui-Ling Liang, Shu-Juan Ma, Yan-Ni Xiao, Hong-Zhuan Tan Comparative efficacy and safety of oral antidiabetic drugs and insulin in treating gestational diabetes mellitus: An updated PRISMA-compliant network meta-analysis. Medicine (Baltimore): 2017, 96(38);e7939 PubMed 28930827
Fatima Vally, Jeffrey Presneill, Thomas Cade Macrosomia Rates in Women with Diet-Controlled Gestational Diabetes: A Retrospective Study. J Pregnancy: 2017, 2017;4935397 PubMed 28928985
Aditi Shruti, George S Wu Case 246: MR Imaging of a Complex Cystic Mass in a Newborn Girl. Radiology: 2017, 285(1);324-328 PubMed 28926319
Birth Weight Classification
|Birth weight (grams)||less 500||500 – 999||1,000 – 1,499||1,500 – 1,999||2,000 – 2,499||2,500 – 2,999||3,000 – 3,499||3,500 – 3,999||4,000 – 4,499||4,500 – 4,999||5,000 or more|
Birth statistics of high birth weight infants (macrosomia) in Korea.
We used 2 data sources, namely, the hospital units (1960's to 1990's) and Statistics Korea (1993 to 2010). The analyses include the incidence of high birth weight infants (HBWIs), birth weight distribution, sex ratio, and the relationship of HBWI to maternal age. The incidence of HBWIs for the past 50 years has been dropping in Korea. The older the mother, the higher was the risk of a HBWI and LBWI. We hope that these findings would be utilized as basic data that will aid those managing HBWIs.
- Jiangfeng Ye, Lin Zhang, Yan Chen, Fang Fang, ZhongCheng Luo, Jun Zhang Searching for the definition of macrosomia through an outcome-based approach. PLoS ONE: 2014, 9(6);e100192 PubMed 24941024 | PLoS One.
- Surabhi Nanda, Ranjit Akolekar, Rita Sarquis, Ana Paula Mosconi, Kypros H Nicolaides Maternal serum adiponectin at 11 to 13 weeks of gestation in the prediction of macrosomia. Prenat. Diagn.: 2011, 31(5);479-83 PubMed 21394735
- J R Bennini, E F Marussi, R Barini, C Faro, C F A Peralta Birth-weight prediction by two- and three-dimensional ultrasound imaging. Ultrasound Obstet Gynecol: 2010, 35(4);426-33 PubMed 20069666
- Neeta Vora, Diana W Bianchi Genetic considerations in the prenatal diagnosis of overgrowth syndromes. Prenat. Diagn.: 2009, 29(10);923-9 PubMed 19609940
- Byung-Ho Kang, Joo-Young Moon, Sung-Hoon Chung, Yong-Sung Choi, Kyung-Suk Lee, Ji-Young Chang, Chong-Woo Bae Birth statistics of high birth weight infants (macrosomia) in Korea. Korean J Pediatr: 2012, 55(8);280-5 PubMed 22977440
Jennifer M Walsh, Fionnuala M McAuliffe Prediction and prevention of the macrosomic fetus. Eur. J. Obstet. Gynecol. Reprod. Biol.: 2012, 162(2);125-30 PubMed 22459652
Paul A O M De Reu, L J M Smits, H P Oosterbaan, J G Nijhuis Value of a single early third trimester fetal biometry for the prediction of birth weight deviations in a low risk population. J Perinat Med: 2008, 36(4);324-9 PubMed 18598122
External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.
- American Academy of Family Physicians Management of Suspected Fetal Macrosomia (2001)
- MedlinePlus Topic
- A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols
Cite this page: Hill, M.A. 2017 Embryology Birth - Macrosomia. Retrieved September 25, 2017, from https://embryology.med.unsw.edu.au/embryology/index.php/Birth_-_Macrosomia
- © Dr Mark Hill 2017, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G