|Embryology - 29 Apr 2016 Translate|
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- 1 Introduction
- 2 Some Recent Findings
- 3 Textbooks
- 4 History
- 5 Gestation Period
- 6 Birth Statistics
- 7 Childbirth
- 8 Uterine Myometrial Changes
- 9 External Environment
- 10 Labor Stages
- 11 Historic Birth Models
- 12 Birth Weights
- 13 Newborn Homoeostasis
- 14 Premature Birth
- 15 Postterm Birth
- 16 Birth Induction
- 17 Symphysiotomy
- 18 Shoulder Dystocia
- 19 Instrumental Assistance
- 20 Neonatal Testing
- 21 Abnormalities
- 21.1 Chapter XV Pregnancy, childbirth and the puerperium (O00-O99)
- 21.2 Chapter XVI Certain conditions originating in the perinatal period (P00-P96)
- 21.3 Uterine Rupture
- 21.4 Amniotic Fluid Embolism
- 21.5 Labor Abnormalities
- 21.6 Placental Abnormalities
- 21.7 Breech Delivery
- 21.8 Meconium Aspiration Syndrome
- 21.9 Necrotizing Enterocolitis
- 22 References
- 23 Birth Terms
- 24 External Links
- 25 Glossary Links
Birth or parturition is a critical stage in development, representing in mammals a transition from direct maternal support of fetal development, physical expulsion and establishment of the newborns own respiratory, circulatory and digestive systems. These notes only cover the biological processes surrounding birth including fetal signaling changes and maternal signaling changes. Note that there is a growing worldwide trend in developed countries toward caesarean section delivery. There are a great number of comprehensive, scientific and general, books and articles that cover birth, childbirth or parturition. The time surrounding birth is known as the perinatal period.
The fetus is thought to initiate the labor process. Recent animal model studies show the maturing fetal lungs express steroid receptor coactivators 1 and 2 (SRC-1 and SRC-2) that induce production of Surfactant protein-A (SP-A) that is then secreted into amniotic fluid initiating parturition.
- Birth Links: Introduction | Lecture - Birth | Caesarean | Preterm | Birth Weight | Birth Statistics | Australian Birth Data | Developmental Origins of Health and Disease | Macrosomia | Neonatal Diagnosis | Apgar test | Guthrie test | Neonatal Development | Stillbirth and Perinatal Death | ICD-10 Perinatal Period | Category:Birth
Some Recent Findings
|More recent papers|
References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.
Haribalakrishna Balasubramanian, Deepika Wagh, Shripada Rao, Anthony D Keil, Judy McMichael Developmental outcomes in cerebrospinal fluid proven enteroviral meningitis in neonates > 32 weeks of gestation. J Paediatr Child Health: 2016, 52(3);327-332 PubMed 27124842
Brian K Gallagher, Yejee Shin, Patrick Roohan Opioid Prescriptions Among Women of Reproductive Age Enrolled in Medicaid - New York, 2008-2013. MMWR Morb. Mortal. Wkly. Rep.: 2016, 65(16);415-417 PubMed 27124815
Liang-Kai Wang, Ming-Chao Huang, Chang-Ching Liu, Chie-Pein Chen Second-trimester plasma mannose-binding lectin levels and risk of preterm birth. J. Matern. Fetal. Neonatal. Med.: 2016;1-31 PubMed 27124763
Michihiro Yoshida, Peijian He, C Chris Yun Transgenic Expression of Human Lysophosphatidic Acid Receptor LPA2 in Mouse Intestinal Epithelial Cells Induces Intestinal Dysplasia. PLoS ONE: 2016, 11(4);e0154527 PubMed 27124742
Lisa Romero, Karen Pazol, Lee Warner, Shanna Cox, Charlan Kroelinger, Ghenet Besera, Anna Brittain, Taleria R Fuller, Emilia Koumans, Wanda Barfield Reduced Disparities in Birth Rates Among Teens Aged 15-19 Years - United States, 2006-2007 and 2013-2014. MMWR Morb. Mortal. Wkly. Rep.: 2016, 65(16);409-414 PubMed 27124706
Search term: Childbirth
Kathleen Chin, Cecilia Wieslander, Haolin Shi, Sunil Balgobin, T Ignacio Montoya, Hiromi Yanagisawa, R Ann Word Pelvic Organ Support in Animals with Partial Loss of Fibulin-5 in the Vaginal Wall. PLoS ONE: 2016, 11(4);e0152793 PubMed 27124299
Franca Tani, Valeria Castagna Maternal social support, quality of birth experience, and post-partum depression in primiparous women. J. Matern. Fetal. Neonatal. Med.: 2016;1-15 PubMed 27123699
Karoline Aebi-Popp, Heather Bailey, Ruslan Malyuta, Alla Volokha, Claire Thorne, Ukraine European Collaborative Study in EuroCoord High prevalence of herpes simplex virus (HSV)- type 2 co-infection among HIV-positive women in Ukraine, but no increased HIV mother-to-child transmission risk. BMC Pregnancy Childbirth: 2016, 16(1);94 PubMed 27121953
Jane Sandall, Hora Soltani, Simon Gates, Andrew Shennan, Declan Devane Midwife-led continuity models versus other models of care for childbearing women. Cochrane Database Syst Rev: 2016, 4;CD004667 PubMed 27121907
Nekisa Haghighat, Maogui Hu, Olivier Laurent, Judith Chung, Peter Nguyen, Jun Wu Comparison of birth certificates and hospital-based birth data on pregnancy complications in Los Angeles and Orange County, California. BMC Pregnancy Childbirth: 2016, 16(1);93 PubMed 27121857
- Human Embryology (2nd ed.) Larson Chapter 15 pp471-488
- The Developing Human: Clinically Oriented Embryology (6th ed.) Moore and Persaud Chapter 7 pp129-167
- General Reading - Pregnancy and Childbirth S Kitzinger Doubleday, Sydney ISBN 0 86824 048 6
- Lecture - Birth
- Practical - Birth
Teaching model of birth.
Magnetic Resonance Imaging of birth.
Gestational Age GA
The American College of Obstetricians and Gynecologists Committee recently (2013) gave an opinion (no 579) definition of "term pregnancy".
- "In the past, the period from 3 weeks before until 2 weeks after the estimated date of delivery was considered "term," with the expectation that neonatal outcomes from deliveries in this interval were uniform and good. Increasingly, however, research has shown that neonatal outcomes, especially respiratory morbidity, vary depending on the timing of delivery within this 5-week gestational age range. To address this lack of uniformity, a work group was convened in late 2012, which recommended that the label "term" be replaced with the designations early term (37 0/7 weeks of gestation through 38 6/7 weeks of gestation), full term (39 0/7 weeks of gestation through 40 6/7 weeks of gestation), late term (41 0/7 weeks of gestation through 41 6/7 weeks of gestation), and postterm (42 0/7 weeks of gestation and beyond) to more accurately describe deliveries occurring at or beyond 37 0/7 weeks of gestation. The American College of Obstetricians and Gynecologists and the Society for Maternal-Fetal Medicine endorse and encourage the uniform use of the work group's recommended"
The American Academy of Pediatrics Committee on Fetus and Newborn (2004) issued a policy statement "Age Terminology During the Perinatal Period" 
- "Gestational age GA (completed weeks): time elapsed between the first day of the last menstrual period and the day of delivery. If pregnancy was achieved using assisted reproductive technology, gestational age is calculated by adding 2 weeks to the conceptional age."
Historically, Franz Carl Naegele (1777-1851) developed the first scientific rule for estimating length of a pregnany. The median duration of gestation for first births from assumed ovulation to delivery was 274 days (just over 39 weeks). For multiple births, the median duration of pregnancy was 269 days (38.4 weeks).
- "...one should count back 3 months from the first day of the last menses, then add 15 days for primiparas or 10 days for multiparas, instead of using the common algorithm for Naegele's rule."
Last Menstrual Period
The Last Menstrual Period (LMP), the menstrual period (menses) that occurs before a pregnancy, has been widely used clinically as a date to calculate clinical pregnancy development (GA, gestational age). Note that in humans this is approximately two weeks different from embryonic development, which begins at fertilisation around the mid-point of the menstrual cycle.
The interval between the beginning of the LMP and fertilisation can have a wide range (7 to 25 days). This variation can be due to both maternal (menstrual cycle timing and ovulation) and fetal (blastocyst implantation) effects. The calculation also requires an accurate maternal recall of LMP and can be affected by irregular menses, first-trimester vaginal bleeding, unrecognized spontaneous abortions, oral contraceptive use.
Measurement of fetal size by ultrasound has been used more recently to accurately calculate pregnancy development. The ultrasound measurement tends to be more accurate in early development staging, by the third trimester there can be some individual variations in fetal growth and the effects of abnormalities or fetal growth restriction. Serial ultrasound measurements may identify these abnormal growth effects.
USA Live Births and Fertility Rates
The 2014 preliminary number of U.S. births was 3,985,924 an increase of 1% from 2013 (Data are based on 99.71% of 2014 births).
| USA Live Births and general fertility rates (1920–2013)
2013 Data Number of births: 3,932,181 births were registered, down less than 1% from 2012.
2007 Data  Number of births: 4,317,119 Birth rate: 14.3 per 1,000 population Fertility rate: 69.5 births per 1000 women aged 15-44 years Percent born low birthweight: 8.2% Percent unmarried: 39.7%
|Scotland - Spontaneous births per 100,000 women of reproductive age, 1980–2004.|
- Parturition (Latin, parturitio = "childbirth") describes expelling the fetus, placenta and fetal membranes and is probably initiated by fetus not mother.
- Preterm birth - Risks of preterm birth in abnormal low birth weight (intrauterine growth restriction) and high (large for gestational age) categories are 2- to 3-fold greater than the risk among appropriate-for-gestational-age infants.
- Maternal labor - uterine contractions and dilation of cervix, process under endocrine regulation
- Placenta and fetal membranes - (Latin, secundina = "following") expelled after neonate birth
Uterine Myometrial Changes
- Smooth muscle fibers - hypertrophy not proliferation
- Stretching of myometrium - stimulates spontaneous muscular contraction, during pregnancy progesterone inhibits contraction
- Stimulating contraction - increased estrogen levels (placental secretion sensitizes smooth muscle), increased oxytocin levels (fetal oxytocin release- force and frequency of contraction), fetal pituitary prostaglandin production (estrogen and oxytocin stimulate endometrial production of prostaglandin)
Oxytocin Receptor Pathways
- mainly shown in other species parturition occurs in peaceful undisturbed surroundings, stress may have an inhibitory effect on oxytocin release
- Most human births occur at night (peak at 3am) diurnal rhythm influence
|Stage 1||Dilatation||7 to 12 hours
longer for first child
|Uterine contractions 10 minutes apart, function to dilate cervix fetal membranes rupture releasing amnion.|
|Stage 2||Expulsion||20 to 50 minutes||Uterine contractions 2 to 3 minutes apart, function to push fetus through cervix and vagina.|
|Stage 3||Placental||15 minutes||Uterine contractions following child delivery expel placenta. Haematoma separates placenta from uterine wall, separation occurs at spongy layer of decidua basalis.|
|Stage 4||Recovery||2+ hours||Uterine contractions continue and myometrial contraction closes spiral arteries, also begins to reduce uterine volume.|
Historic Birth Models
About The Models - a series of models commissioned by Giuseppe Galletti (? - 1819) currently held in the Institute and Museum of the History of Science (Italy) Istituto e Museo di Storia della Scienza (IMSS). Giuseppe Galletti and others used terracotta and wax models that he had commissioned in Florence between 1770 and 1775 to train surgeons and midwives.
The primary causes of VLBW are premature birth (born <37 weeks gestation, and often <30 weeks) and intrauterine growth restriction (IUGR), usually due to problems with placenta, maternal health, or to birth defects. Many VLBW babies with IUGR are preterm and thus are both physically small and physiologically immature.
|Birth weight (grams)||less 500||500 – 999||1,000 – 1,499||1,500 – 1,999||2,000 – 2,499||2,500 – 2,999||3,000 – 3,499||3,500 – 3,999||4,000 – 4,499||4,500 – 4,999||5,000 or more|
|Classification||Extremely Low Birth Weight||Very Low Birth Weight||Low Birth Weight||Normal Birth Weight||High Birth Weight|
Extremely Low Birth Weight
- Less than 500 grams (1 lb 1 oz or less)
- 500 – 999 grams (1 lb 2 oz – 2 lb 3 oz)
Very Low Birth Weight
- 1,000 – 1,499 grams (2 lb 4 oz – 3 lb 4 oz)
Low Birth Weight
- 1,500–1,999 grams (3 lb 5 oz – 4 lb 6 oz)
- 2,000–2,499 grams (4 lb 7 oz – 5 lb 8 oz)
Normal Birth Weight
- 2,500–2,999 grams (5 lb 9 oz – 6 lb 9 oz)
- 3,000–3,499 grams (6 lb 10 oz – 7 lb 11 oz)
- 3,500–3,999 grams (7 lb 12 oz – 8 lb 13 oz)
High Birth Weight (macrosomia)
- 4,000–4,499 grams (8 lb 14 oz – 9 lb 14 oz)
- 4,500–4,999 grams (9 lb 15 oz – 11 lb 0 oz)
- 5,000 grams or more (11 lb 1 oz or more)
Newborn has to establish new functioning systems in a balanced and regulated manner (homoeostasis).
- lung function
- circulatory changes
- endocrine function
- gastrointestinal tract function
- kidney function
Glucocorticoids - have an important role in the preparation for birth, including involvement in lung and cardiac development, and the maturation of enzymes in a variety of pathways.
- Lungs at birth collapsed and fluid-filled - replaced with air by powerful inspiratory movement and absorption through the alveoli
- Lung epithelia has to rapidly change from its prenatal secretory function to that of fluid absorbtion.
- initiated by a late fetal change in alveolar epithelial cell (AEC) chloride and fluid secretion to sodium and fluid absorption.
- absorption requires sodium-potassium ATPase (Na-K-ATPase) together with apical sodium entry mechanisms (Epithelial Sodium Channels, ENaC)
- Fetal thyroid hormone is thought to have a hormonal role in this developmental switch
- These changes and pressure also lead to the pulmonary sytem becoming activated and changes in the circulatory shunting that existed before birth.
- During the late fetal period regular fetal breathing movements (FBM) also occur preparing both the skeletomuscular sysyem and lungs mechanically for respiration.
- Respiratory Rate is higher than adult (30 breaths/minute).
- Rib Orientation - Infant rib is virtually horizontal, allowing diaphragmatic breathing only. Adult rib orientation is oblique (both anterior and lateral views), allows for pump-handle and bucket handle types of inspiration.
The First Breath
The exchange of lung fluid for air leads to:
- fall in pulmonary vascular resistance
- increase in pulmonary blood flow
- thinning of pulmonary arteries (stretching as lungs increase in size)
- blood fills the alveolar capillaries
- In the heart, pressure in the right side of the heart decreases and pressure in the left side of the heart increases (more blood returning from pulmonary).
See also the review; Clearance of lung liquid during the perinatal period "At birth, the distal lung epithelium undergoes a profound phenotypic switch from secretion to absorption in the course of adaptation to air breathing."
- Umbilical Vasculature - The umbilical blood vessel cavity is lost postnatally over the course of weeks to months after birth. The adult anatomical remnant of the umbilical vein between the umbilicus and liver is the ligamentum teres.
- Foramen Ovale - two separate forms of foramen ovale closure; functional and structural. Functional closure begins at the first breath and is rapid. Structural (anatomical) closure is much slower and generally occurs before the end of the first year.
- Ductus Arteriosus - a direct connection between the pulmonary trunk and the dorsal aorta. Postnatal closure occurs initially by by smooth muscle contraction and begins at the first breath and is rapid, completed within the first day (about 15 hr after birth). Anatomical closure is much slower occuring by 2–3 weeks after birth (33% of infants), by 2 months (90% of infants) and by 1 year (99% of infants). The adult anatomical remnant of the ductus arteriosus is the ligamentum arteriosum.
- Ductus Venosus - connects portal and umbilical blood to the inferior vena cava. Functional closure occurs postnatally within hours. Structural closure commences days after birth and completes by 18 to 20 days. The adult anatomical remnant of the ductus venosus is the ligamentum venosum (a dorsal fissure on the liver).
|Year||< 34 weeks %||34-36 weeks %||total preterm %|
Data: Prevention of preterm birth: a renewed national priority 
- less than 23 weeks survival is minimal and the risk of major morbidity is so high that initiation of resuscitation is not appropriate.
- 23 weeks active treatment may be discussed, but would be discouraged in NSW/ACT neonatal intensive care units.
- 23 to 25 weeks otherwise normal infant, there is an increasing obligation to treat. However, it is acceptable medical practice not to initiate intensive care if parents so wish, following appropriate counselling.
- 24 weeks antenatal transfer to a tertiary centre for fetal reasons is indicated. The option of non-initiation of intensive care/resuscitation should be offered.
- 25 weeks active treatment is usually offered, but the option of non-initiation of intensive care/resuscitation (presence of adverse fetal factors such as twin-to-twin transfusion, intrauterine growth restriction or chorioamnionitis) should also be discussed.
- 26 weeks or more otherwise normal infant the obligation to treat is very high, and treatment should generally be initiated unless there are exceptional circumstances.
- "A grey zone between 23(0) and 25(6) weeks of gestation was identified and agreed upon. In this grey zone, while there was an increasing obligation to treat, it was acceptable not to initiate intensive care following appropriate counselling with parents. Important areas identified before birth, were continuing communication between the perinatal team and parents, a review of choice with continued counselling, decision support and empathy." 
Postterm pregnancy is a ((GA) of 42 weeks or beyond and has risks for both infant and mother (see review).
- incidence of stillbirth increases from GA 39 weeks onwards
- incidence of stillbirth has a sharp rise after GA of 40 weeks
Maternal and Neonatal Outcomes of Elective Induction of Labor
AHRQ Evidence Report 2009 (USA)
- Induction of labor is on the rise in the USA, increasing from 9.5 percent in 1990 to 22.1 percent in 2004.
- Although, it is not entirely clear what proportion of these inductions are elective (i.e. without a medical indication), the overall rate of induction of labor is rising faster than the rate of pregnancy complications that would lead to a medically indicated induction. However, the maternal and neonatal effects of induction of labor are unclear. Many studies compare women with induction of labor to those in spontaneous labor. This is problematic, because at any point in the management of the woman with a term gestation, the clinician has the choice between induction of labor and expectant management, not spontaneous labor. Expectant management of the pregnancy involves nonintervention at any particular point in time and allowing the pregnancy to progress to a future gestational age. Thus, women undergoing expectant management may go into spontaneous labor or may require indicated induction of labor at a future gestational age.
- Randomized controlled trials suggest that elective induction of labor at 41 weeks of gestation and beyond may be associated with a decrease in both the risk of cesarean delivery and of meconium-stained amniotic fluid. The evidence regarding elective induction of labor prior to 41 weeks of gestation is insufficient to draw any conclusion. There is a paucity of information from prospective RCTs examining other maternal or neonatal outcomes in the setting of elective induction of labor. Observational studies found higher rates of cesarean delivery with elective induction of labor, but compared women undergoing induction of labor to women in spontaneous labor and were subject to potential confounding bias, particularly from gestational age. Such studies do not inform the question of how elective induction of labor affects maternal or neonatal outcomes. Elective induction of labor at 41 weeks of gestation and potentially earlier also appears to be a cost-effective intervention, but because of the need for further data to populate these models our analyses are not definitive. Despite the evidence from the prospective, RCTs reported above, there are concerns about the translation of such findings into actual practice, thus, there is a great need for studying the translation of such research into settings where the majority of obstetric care is provided.
A clinical procedure (operation) carried out to increase pelvic outlet size and to permit vaginal delivery of a baby, the surgical procedure involves dividing the cartilage of the symphysis pubis. This can be employed for a number of birth related issues including: lack of caesarean option, obstructed birth, breech birth and shoulder dystonia.
The operation can lead to transient maternal pelvic instability. A recent Cochrane study looking at "the effectiveness and safety of symphysiotomy versus alternative options for obstructed labour in various clinical situations" identified no randomized trials of symphysiotomy.
Term describing a birth condition where the fetal bisacromial diameter is greater than the maternal pelvic inlet antero-posterior diameter. This leads to the fetal anterior shoulder becoming impacted behind the maternal pubic symphysis. More simply, the shoulder becomes "stuck" during birth. This condition generally has a low incidence, but can occur in up to 3% of all births and there are a range of clinical procedures employed to overcome the problem depending on the degree and stage of birth. Effects associated with this clinical condition include fetal clavicle (collar bone) breakage and brachial plexus damage.
It is thought that the recent trend for increasing maternal obesity has in turn led to increasing fetal macrosomy that has increased shoulder dystocia and fetal clavicle breakage.
Clinical procedures: suprapubic pressure with normal downward traction on fetal head, McRoberts maneuver, Wood's screw maneuver, Posterior arm extraction and Procto-episiotomy.
- Links: American Academy of Family Physicians - Shoulder Dystocia | Australia - The Royal Women’s Hospital | search pubmed
Birth - cephalic presentations
The two main forms of instrumental assistance to expedite vaginal delivery with either vacuum or forceps. There can be associated complications for both mother and infant with these procedures, that influence assistance selection.
A vacuum device (metal or rubber-type cup with tubing attached) used to assist the delivery of a infant when the second stage of labour has not progressed adequately.
A surgical instrument similar to a pair of tongs used to mechanically assist the delivery of a infant. The modern instrument was historically developed several hundred years ago to grab and manoeuvre the fetus through the birth canal.
A historic neonatal test designed by Dr Virginia Apgar used in nearly all maternity clinics to assess the newborn infants well being assigned scores for each of 5 indicators: Heart Rate, Respiratory Effort, Reflex Irritability, Muscle Tone, Colour Measured at one and five minutes after birth the Score values are totalled for all indicators: 7-10 is considered normal, 4-7 may require resuscitative measures, 3 and below require immediate resuscitation. In recent years there has been some controversy of the relevance and accuracy of some of the criteria used in this test, though many feel it is still an invaluable initial assessment tool particularly where medical services are limited.
- Measured at one and five minutes after birth.
- The Score values are totalled for all indicators
- 7 to 10 is considered normal
- 4 to 7 may require resuscitative measures
- 3 and below require immediate resuscitation
|Indicator||Score 0||Score 1||Score 2|
|Limp; no movement||Some flexion of arms and legs||Active motion|
|No heart rate||Fewer than 100 beats per minute||At least 100 beats per minute|
|No response to airways being suctioned||Grimace during suctioning||Grimace and pull away, cough, or sneeze during suctioning|
|The baby's whole body is completely bluish-gray or pale||Good color in body with bluish hands or feet||Good color all over|
|Not breathing||Weak cry; may sound like whimpering, slow or irregular breathing||Good, strong cry; normal rate and effort of breathing|
- Links: Apgar test
A blood screening test developed by Dr Robert Guthrie (1916-95) at University of Buffalo. The test is carried out on neonatal (newborn) blood detecting markers for a variety of known disorders (phenylketonuria (PKU), hypothyroidism and cystic fibrosis). In the Australian states of NSW and Victoria, the Guthrie Cards are currently stored indefinitely.
- Links: Guthrie test
There are many birth associated abnormalities, only a few examples are listed below. In particular the perinatal period is a time when fetal systems that have either not yet been functional (respiratory, gastrointestinal, neural) or are extensively remodelled (cardiovascular, placental). There are also a number of maternal issues.
The International Classification of Diseases (ICD) has two entire chapters committed to the childbirth and the perinatal period, the major sub-headings are shown below. More detail is available on the chapter pages, Chapter XV Pregnancy Childbirth and Chapter XVI Perinatal Period. The World Health Organization's ICD classification used worldwide as the standard diagnostic tool for epidemiology, health management and clinical purposes. This includes the analysis of the general health situation of population groups. It is used to monitor the incidence and prevalence of diseases and other health problems.
Chapter XV Pregnancy, childbirth and the puerperium (O00-O99)
The codes included in this chapter are to be used for conditions related to or aggravated by the pregnancy, childbirth or by the puerperium (maternal causes or obstetric causes)
- Excludes Certain diseases or injuries complicating pregnancy, childbirth and the puerperium classified elsewhere: external causes (for mortality) (V, W, X, Y); injury, poisoning and certain other consequences of external cause (S00-T88.1, , T88.6-T98); mental and behavioural disorders associated with the puerperium (F53.-); obstetrical tetanus (A34); postpartum necrosis of pituitary gland (E23.0); puerperal osteomalacia (M83.0); supervision of high-risk pregnancy (Z35.-); supervision of normal pregnancy (Z34.-).
- O00-O08 - Pregnancy with abortive outcome.
- O10-O16 - Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium.
- O20-O29 - Other maternal disorders predominantly related to pregnancy.
- O30-O48 - Maternal care related to the fetus and amniotic cavity and possible delivery problems.
- O60-O75 - Complications of labour and delivery.
- O80-O84 - Delivery.
- O85-O92 - Complications predominantly related to the puerperium.
- O94-O99 - Other obstetric conditions, not elsewhere classified.
Chapter XVI Certain conditions originating in the perinatal period (P00-P96)
Includes conditions that have their origin in the perinatal period even though death or morbidity occurs later.
- Excludes congenital malformations, deformations and chromosomal abnormalities (Q00-Q99); endocrine, nutritional and metabolic diseases (E00-E90); injury, poisoning and certain other consequences of external causes (S00-T98); neoplasms (C00-D48); tetanus neonatorum (A33)
Major sub-headings are shown below, select the sub-heading link to see details.
- P00-P04 - Fetus and newborn affected by maternal factors and by complications of pregnancy, labour and delivery.
- P05-P08 - Disorders related to length of gestation and fatal growth.
- P10-P15 - Birth trauma.
- P20-P29 - Respiratory and cardiovascular disorders specific to the perinatal period.
- P35-P39 - Infections specific to the perinatal period.
- P50-P61 - Haemorrhagic and haematological disorders of fetus and newborn.
- P70-P74 - Transitory endocrine and metabolic disorders specific to fetus and newborn.
- P75-P78 - Digestive system disorders of fetus and newborn.
- P80-P83 - Conditions involving the integument and temperature regulation of fetus and newborn.
- P90-P96 - Other disorders originating in the perinatal period.
- Links: XV Pregnancy Childbirth | International Classification of Diseases - XVI Perinatal Period | International Classification of Diseases | Human Abnormal Development
Maternal uterine rupture is defined as an anatomic separation of the uterine muscle with or without symptoms and has adverse consequences for both mother and infant. AN NIH consensus conferenceidentified a increased risk of uterine rupture in women who have a trial of labor compared to elective repeat cesarean delivery. "There have been no reported maternal deaths due to uterine rupture. Overall, 14 to 33 percent of women will need a hysterectomy when the uterus ruptures. Approximately 6 percent of uterine ruptures will result in perinatal death. This is an overall risk of intrapartum fetal death of 20 per 100,000 women undergoing trial of labor. For term pregnancies, the reported risk of fetal death with uterine rupture is less than 3 percent. Although the risk is similarly low, there is insufficient evidence to quantify the neonatal morbidity directly related to uterine rupture."
- ICD: O71.0 Rupture of uterus before onset of labour | O71.1 Rupture of uterus during labour, Rupture of uterus not stated as occurring before onset of labour | Uterus Abnormalities | Uterus Development
Amniotic Fluid Embolism
(AFE) Clinical term for a rare obstetric emergency in which conceptus material (amniotic fluid, fetal cells, hair, or other fetal debris) enter the maternal circulation from the placenta and lead to an allergic reaction followed by maternal cardiorespiratory collapse. Amniotic fluid can enter maternal circulation through tears in the uterus or cervix during labour and delivery, or through partial separation of the placenta.
A recent international study has attempted to standardise how AFE data is collected and recommended:
- Comparisons of AFE incidence estimates should be restricted to studies using similar methodology. The recommended approaches would be either population-based database studies using additional criteria to exclude false positive cases, or tailored data collection using existing specific population-based systems.
- Comparisons of AFE incidence between and within countries would be facilitated by development of an agreed case definition and an agreed set of criteria to minimise inclusion of false positive cases for database studies.
- Groups conducting detailed population-based studies on AFE should develop an agreed strategy to allow combined analysis of data obtained using consistent methodologies in order to identify potentially modifiable risk factors.
- Future specific studies on AFE should aim to collect information on management and longer-term outcomes for both mothers and infants in order to guide best practice, counselling and service planning.
- Premature Labor - occurs 7 -10% in humans, contributes 75% perinatal mortalities
- Underdeveloped Systems - particularly respiratory, surfactant, hyaline membrane disease (see respiratory development lecture)
- placenta accreta - abnormal adherence, with absence of decidua basalis
- placenta percreta - villi penetrate myometrium
- placenta previa - placenta overlies internal os of uterus, abnormal bleeding, cesarian delivery
- Historically, breech-born children were called agrippi, meaning "delivered with difficulty" (aegre parti).
- Breech position - occurs in about 3% of fetuses when buttocks or lower limb are presented to the birth canal rather than normal cephalic (head-first) position (presentation).
- Associated increased - perinatal mortality, perinatal morbidity, recurrence in successive siblings
Current research suggests that genetically that both men and women delivered in breech presentation at term could also contribute to an increased risk of breech delivery in their offspring. ([#18369204 Nordtveit TI, etal., 2008])
Meconium Aspiration Syndrome
- meconium is formed from gut and associated organ secretions as well as cells and debris from the swallowed amniotic fluid.
- Meconium accumulates during the fetal period in the large intestine (bowel). It can be described as being a generally dark colour (green black) , sticky and odourless.
- Normally this meconium is defaecated (passed) postnatally over the first 48 hours and then transitional stools from day 4.
- Abnormally this meconium is defaecated in utero, due to oxygen deprivation and other stresses. Premature discharge into the amniotic sac can lead to mixing with amniotic fluid and be reswallowed by the fetus. This is meconium aspiration syndrome and can damage both the developing lungs and placental vessels.
Occurs postnatally in mainly in premature and low birth weight infants (1 in 2,000 - 4,000 births). The underdeveloped gastointestinal tract appears to be susceptible to bacteria, normally found within the tract,to spread widely to other regions where they damage the tract wall and may enter the bloodstream.
- Lu Gao, Elizabeth H Rabbitt, Jennifer C Condon, Nora E Renthal, John M Johnston, Matthew A Mitsche, Pierre Chambon, Jianming Xu, Bert W O'Malley, Carole R Mendelson Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition. J. Clin. Invest.: 2015; PubMed 26098214
- Broekman BFP, Wang C, Li Y, Rifkin-Graboi A, Saw SM, et al. (2014) Gestational Age and Neonatal Brain Microstructure in Term Born Infants: A Birth Cohort Study. PLoS ONE 9(12): e115229. doi:10.1371/journal.pone.0115229
- ACOG Committee Opinion No 579: Definition of term pregnancy. Obstet Gynecol: 2013, 122(5);1139-40 PubMed 24150030
- Kirsti Myklestad, Lars Johan Vatten, Elisabeth Balstad Magnussen, Kjell Åsmund Salvesen, Pål Richard Romundstad Do parental heights influence pregnancy length?: A population-based prospective study, HUNT 2. BMC Pregnancy Childbirth: 2013, 13;33 PubMed 23383756
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- amniotomy - birth medical procedure thought to speed labor, where the amniotic sac is artificially ruptured using a tool (amniohook).
- birth - (parturition, partus, childbirth, labour, delivery). expulsion of the foetus from the uterus. (More? Birth)
- birth weight - (birth-weight) the weight of the neonate measured as soon as possible after birth. (More? Birth Weight)
- breech - fetal buttocks presented first and can also occur in different forms depending on presentation (complete breech, frank breech, footing breech, knee breech).
- decidual activation - increased uterine proteolysis and extracellular matrix degradation.
- dilatation - opening of the cervix in preparation for birth (expressed in centimetres).
- effacement - shortening or thinning of the cervix, in preparation for birth.
- forceps - mechanical "plier-like" tool used on fetal head to aid birth.
- labor - the maternal physiological process of birth. (More? Birth)
- macrosomia - clinical description for a fetus that is too large, condition increases steadily with advancing gestational age and defined by a variety of birthweights. In pregnant women anywhere between 2 - 15% have birth weights of greater than 4000 grams (4 Kg, 8 lb 13 oz). (More? Macrosomia)
- membrane rupture - breaking of the amniotic membrane and release of amniotic fluid (water breaking).
- morbidity - (Latin, morbidus = "sick" or "unhealthy") refers to a diseased state, disability, or poor health due to any cause.
- neonatal - the early postnatal period relating to the birth, it includes the period up to 4 weeks after birth.
- perinatal - the early postnatal period relating to the birth, statistically it includes the period up to 7 days after birth.
- presentation - how the fetus is situated in the uterus.
- presenting part - part of fetus body that is closest to the cervix.
- second stage of labour - passage of the baby through the birth canal into the outside world.
- vacuum extractor - (ventouse) rubber or metal suction cap device used on fetal head to aid birth.
- vertex presentation - (cephalic presentation) where the fetus head is the presenting part, most common and safest birth position.
External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name.
- The Journal of Perinatal Education
- Australia - Victorian Department of Health Neonatal ehandbook - structured approach to the clinical management of conditions regularly encountered by health professionals caring for newborns.
- System Links: Introduction | Cardiovascular | Coelomic Cavity | Endocrine | Gastrointestinal Tract | Genital | Head | Immune | Integumentary | Musculoskeletal | Neural | Neural Crest | Placenta | Renal | Respiratory | Sensory | Birth
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Cite this page: Hill, M.A. (2016) Embryology Birth. Retrieved April 29, 2016, from https://embryology.med.unsw.edu.au/embryology/index.php/Birth
- © Dr Mark Hill 2016, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G