Talk:Cardiovascular System - Heart Development
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Cite this page: Hill, M.A. (2024, April 27) Embryology Cardiovascular System - Heart Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Talk:Cardiovascular_System_-_Heart_Development |
Coronary vessel development: a unique form of vasculogenesis. http://www.ncbi.nlm.nih.gov/pubmed/14525796
2011
Zebrafish cardiac development requires a conserved secondary heart field
Development. 2011 Jun;138(11):2389-98.
Hami D, Grimes AC, Tsai HJ, Kirby ML. Source Department of Pediatrics, Duke University, Durham, NC 27710, USA.
Abstract
The secondary heart field is a conserved developmental domain in avian and mammalian embryos that contributes myocardium and smooth muscle to the definitive cardiac arterial pole. This field is part of the overall heart field and its myocardial component has been fate mapped from the epiblast to the heart in both mammals and birds. In this study we show that the population that gives rise to the arterial pole of the zebrafish can be traced from the epiblast, is a discrete part of the mesodermal heart field, and contributes myocardium after initial heart tube formation, giving rise to both smooth muscle and myocardium. We also show that Isl1, a transcription factor associated with undifferentiated cells in the secondary heart field in other species, is active in this field. Furthermore, Bmp signaling promotes myocardial differentiation from the arterial pole progenitor population, whereas inhibiting Smad1/5/8 phosphorylation leads to reduced myocardial differentiation with subsequent increased smooth muscle differentiation. Molecular pathways required for secondary heart field development are conserved in teleosts, as we demonstrate that the transcription factor Tbx1 and the Sonic hedgehog pathway are necessary for normal development of the zebrafish arterial pole.
PMID 21558385