Neural Crest - Peripheral Nervous System

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Introduction

Human embryo neural crest cells (stage 11)

The neural crest are bilaterally paired strips of cells arising in the ectoderm at the margins of the neural tube. These cells migrate to many different locations and differentiate into many cell types within the embryo. This means that many different systems (neural, skin, teeth, head, face, heart, adrenal glands, gastrointestinal tract) will also have a contribution fron the neural crest cells.


In the body region, neural crest cells also contribute the peripheral nervous system (both neurons and glia) consisting of sensory ganglia (dorsal root ganglia), sympathetic and parasympathetic ganglia and neural plexuses within specific tissues/organs.


In the head region, neural crest cells migrate into the pharyngeal arches (as shown in movie below) forming ectomesenchyme contributing tissues which in the body region are typically derived from mesoderm (cartilage, bone, and connective tissue).General neural development is also covered in Neural Notes.


Neural Crest Links: neural crest | Lecture - Early Neural | Lecture - Neural Crest Development | Lecture Movie | Schwann cell | adrenal | melanocyte | Peripheral Nervous System | enteric nervous system | cornea | Cranial Nerves | Cardiac | Nicole Le Douarin | Neural Crest Movies | neural crest abnormalities | Category:Neural Crest
Historic Embryology - Neural Crest  
1879 Olfactory Organ | 1905 Cranial and Spinal Nerves | 1908 10 mm Peripheral | 1910 Mammal Sympathetic | 1920 Human Sympathetic | 1939 10 Somite Embryo | 1942 Origin | 1957 Adrenal

Some Recent Findings

  • Neuronal differentiation in the developing human spinal ganglia[1] "The spatiotemporal developmental pattern of the neural crest cells differentiation towards the first appearance of the neuronal subtypes was investigated in developing human spinal ganglia between the 5th -10th developmental week using immunohistochemistry and immunofluorescence methods. First NF200 (neurofilament-200, likely-myelinated mechanoreceptors) and isolectin-B4 positive neurons (likely-unmyelinated nociceptors) appeared already in the 5/6th developmental week and their number subsequently increased during progression of development. Proportion of NF200 positive cells was higher in the ventral parts of the spinal ganglia than in the dorsal parts, particularly during the 5/6th and 9/10th developmental weeks (Mann-Whitney, p=0.040 and p=0.003). NF200 and IB4 co-localized during the whole investigated period. Calcitonin gene-related peptide (CGRP, nociceptive responses), vanilloid-receptor-1 (VR1, polymodal nociceptors) and calretinin (calcium signalling) cell immunoreactivity first appeared in the 6th and 8th week, respectively, especially in the dorsal parts of the spinal ganglia. VR1 and CGRP co-localized with NF00 during the whole investigated period. Our results indicate the high potential of early differentiated neuronal cells, which slightly decreased with progression of spinal ganglia differentiation. On the contrary, the number of neuronal subtypes displayed increasing differentiation at later developmental stage."
  • The role of the transcription factor Rbpj in the development of dorsal root ganglia[2] "The dorsal root ganglion (DRG) is composed of well-characterized populations of sensory neurons and glia derived from a common pool of neural crest stem cells (NCCs), and is a good system to study the mechanisms of neurogenesis and gliogenesis. Notch signaling is known to play important roles in DRG development, but the full scope of Notch functions in mammalian DRG development remains poorly understood."
  • Cranial neural crest migration: new rules for an old road.[3] "In this review, we discuss recent cellular and molecular discoveries of the CNCC migratory pattern. We focus on events from the time when CNCCs encounter the tissue adjacent to the neural tube and their travel through different microenvironments and into the branchial arches. We describe the patterning of discrete cell migratory streams that emerge from the hindbrain, rhombomere (r) segments r1-r7, and the signals that coordinate directed migration."
More recent papers  
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This table shows an automated computer PubMed search using the listed sub-heading term.

  • Therefore the list of references do not reflect any editorial selection of material based on content or relevance.
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References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.

Links: References | Discussion Page | Pubmed Most Recent | Journal Searches


Search term: Peripheral Nervous System Development

Yuki Miyamoto, Tomohiro Torii, Masashi Inoue, Takako Morimoto, Masahiro Yamamoto, Junji Yamauchi Data on the effect of knockout of neruregulin-1 type III on Remak bundle structure. Data Brief: 2018, 18;803-807 PubMed 29900241

Serena Stanga, Liliana Brambilla, Bernadette Tasiaux, Anh H Dang, Adrian Ivanoiu, Jean-Noël Octave, Daniela Rossi, Vincent van Pesch, Pascal Kienlen-Campard A Role for GDNF and Soluble APP as Biomarkers of Amyotrophic Lateral Sclerosis Pathophysiology. Front Neurol: 2018, 9;384 PubMed 29899726

Yanqing Wu, Zhouguang Wang, Pingtao Cai, Ting Jiang, Yiyang Li, Yuan Yuan, Rui Li, Sinan Khor, Yingfeng Lu, Jian Wang, Daqing Chen, Qiqiang Zeng, Ruisheng Zhong, Hongyu Zhang, Yuan Lin, Xiaokun Li, Jian Xiao Dual Delivery of bFGF- and NGF-Binding Coacervate Confers Neuroprotection by Promoting Neuronal Proliferation. Cell. Physiol. Biochem.: 2018, 47(3);948-956 PubMed 29895019

Marc Ferrer, Sara J C Gosline, Marigo Stathis, Xiaohu Zhang, Xindi Guo, Rajarshi Guha, Dannielle A Ryman, Margaret R Wallace, Laura Kasch-Semenza, Haiping Hao, Roxann Ingersoll, David Mohr, Craig Thomas, Sharad Verma, Justin Guinney, Jaishri O Blakeley Pharmacological and genomic profiling of neurofibromatosis type 1 plexiform neurofibroma-derived schwann cells. Sci Data: 2018, 5;180106 PubMed 29893754

Morgane Sonia Thion, Sandrine Humbert Cancer: From Wild-Type to Mutant Huntingtin. J Huntingtons Dis: 2018; PubMed 29889077


Search term: Dorsal Root Ganglia Development

Ryan A Mischel, William L Dewey, Hamid I Akbarali Tolerance to Morphine-Induced Inhibition of TTX-R Sodium Channels in Dorsal Root Ganglia Neurons Is Modulated by Gut-Derived Mediators. iScience: 2018, 2;193-209 PubMed 29888757

Nitesh P Patel, Kristopher A Lyon, Jason H Huang An update-tissue engineered nerve grafts for the repair of peripheral nerve injuries. Neural Regen Res: 2018, 13(5);764-774 PubMed 29862995

Fu-Chen Yang, Julia Draper, Peter G Smith, Jay L Vivian, Steven M Shapiro, John A Stanford Short Term Development and Fate of MGE-Like Neural Progenitor Cells in Jaundiced and Non-Jaundiced Rat Brain. Cell Transplant: 2018;963689718766327 PubMed 29845869

Serena Viventi, Mirella Dottori Modelling the Dorsal Root Ganglia using Human Pluripotent Stem Cells: A Platform to Study Peripheral Neuropathies. Int. J. Biochem. Cell Biol.: 2018; PubMed 29772357

Rachel M Bailey, Diane Armao, Sahana Nagabhushan Kalburgi, Steven J Gray Development of Intrathecal AAV9 Gene Therapy for Giant Axonal Neuropathy. Mol Ther Methods Clin Dev: 2018, 9;160-171 PubMed 29766026


Search term: Sympathetic Development

S Obernikhin, N Yaglova, D Tsomartova, V Torbek, M Ivanova [EPIGENETIC REGULATION OF ADRENAL CHROMAFFIN CELLS DEVELOPMENT (REVIEW)]. Georgian Med News: 2018, (278);138-146 PubMed 29905560

Yasuyuki Fujii, Kenta Suzuki, Yahiro Hasegawa, Fumio Nanba, Toshiya Toda, Takahiro Adachi, Shu Taira, Naomi Osakabe Single oral administration of flavan 3-ols induces stress responses monitored with stress hormone elevations in the plasma and paraventricular nucleus. Neurosci. Lett.: 2018; PubMed 29902479

Javeria N Syeda, Ian H Rutkofsky, Adnan S Muhammad, Tarig H Balla Abdalla, Zahid Saghir The Psycho-cardiac Coupling, Myocardial Remodeling, and Neuroendocrine Factor Levels: The Psychosomatics of Major Depressive Disorder. Cureus: 2018, 10(4);e2464 PubMed 29900084

Mario A Inchiosa Anti-tumor activity of phenoxybenzamine and its inhibition of histone deacetylases. PLoS ONE: 2018, 13(6);e0198514 PubMed 29897996

Andreas M Weng, Stefan Wilimsky, Gwendolyn Bender, Stefanie Hahner, Herbert Köstler, Christian O Ritter Magnetic resonance cold pressor test to investigate potential endothelial dysfunction in patients suffering from type 1 diabetes. J Magn Reson Imaging: 2018; PubMed 29897641

Neural Crest Migration


Movie Source: Original Neural Crest movies kindly provided by Paul Kulesa.[4]

Related Movies: Migration 01 | Migration 02 | Migration 03 | Migration 04 | Migration 05 | Migration 06 | Migration 07

Development Overview

The following cranial and trunk data is based upon 185 serially sectioned staged (Carnegie) human embryos.[5]

Cranial Neural Crest

  • stage 9 - an indication of mesencephalic neural crest
  • stage 10 - trigeminal, facial, and postotic components
  • stage 11 - crest-free zones are soon observable in rhombomere 1, 3, and 5
  • stage 12 - rhombomeres 6 and 7 neural crest migrate to pharyngeal arch 3 and then rostrad to the truncus arteriosus
  • stage 13 - nasal crest and the terminalis-vomeronasal complex are last of the cranial crest to appear

stages 9-14 - otic vesicle primordium descends

Trunk Neural Crest

Spinal ganglia increase in number over time and are in phase with the somites, though not their centre. There are 3 migratory pathways: ventrolateral between dermatomyotome and sclerotome, ventromedial between neural tube and sclerotomes, and lateral between surface ectoderm and dermatomyotome.

  • stage 13 - about 19 present
  • stage 14 - about 33 present
  • stage 15-23 - 30–35 ganglia

References

  1. Vukojevic K, Filipovic N, Tica Sedlar I, Restovic I, Bocina I, Pintaric I & Saraga-Babic M. (2016). Neuronal differentiation in the developing human spinal ganglia. Anat Rec (Hoboken) , 299, 1060-72. PMID: 27225905 DOI.
  2. Hu ZL, Shi M, Huang Y, Zheng MH, Pei Z, Chen JY, Han H & Ding YQ. (2011). The role of the transcription factor Rbpj in the development of dorsal root ganglia. Neural Dev , 6, 14. PMID: 21510873 DOI.
  3. Kulesa PM, Bailey CM, Kasemeier-Kulesa JC & McLennan R. (2010). Cranial neural crest migration: new rules for an old road. Dev. Biol. , 344, 543-54. PMID: 20399765 DOI.
  4. Kulesa PM & Fraser SE. (2000). In ovo time-lapse analysis of chick hindbrain neural crest cell migration shows cell interactions during migration to the branchial arches. Development , 127, 1161-72. PMID: 10683170
  5. O'Rahilly R & Müller F. (2007). The development of the neural crest in the human. J. Anat. , 211, 335-51. PMID: 17848161 DOI.


Reviews

Krispin S, Nitzan E & Kalcheim C. (2010). The dorsal neural tube: a dynamic setting for cell fate decisions. Dev Neurobiol , 70, 796-812. PMID: 20683859 DOI.

Ernsberger U. (2009). Role of neurotrophin signalling in the differentiation of neurons from dorsal root ganglia and sympathetic ganglia. Cell Tissue Res. , 336, 349-84. PMID: 19387688 DOI.

Sarnat HB & Flores-Sarnat L. (2005). Embryology of the neural crest: its inductive role in the neurocutaneous syndromes. J. Child Neurol. , 20, 637-43. PMID: 16225807 DOI.

Chen HH, Hippenmeyer S, Arber S & Frank E. (2003). Development of the monosynaptic stretch reflex circuit. Curr. Opin. Neurobiol. , 13, 96-102. PMID: 12593987

Schober A & Unsicker K. (2001). Growth and neurotrophic factors regulating development and maintenance of sympathetic preganglionic neurons. Int. Rev. Cytol. , 205, 37-76. PMID: 11336393

Articles

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Search Pubmed: Peripheral Neural Development | Dorsal Root Ganglia Development | Sympathetic Neural Development | Parasympathetic Neural Development | Neural Crest Development

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Cite this page: Hill, M.A. (2018, June 18) Embryology Neural Crest - Peripheral Nervous System. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Neural_Crest_-_Peripheral_Nervous_System

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