Neural Crest - Peripheral Nervous System
|Embryology - 25 Apr 2018 Expand to Translate|
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The neural crest are bilaterally paired strips of cells arising in the ectoderm at the margins of the neural tube. These cells migrate to many different locations and differentiate into many cell types within the embryo. This means that many different systems (neural, skin, teeth, head, face, heart, adrenal glands, gastrointestinal tract) will also have a contribution fron the neural crest cells.
In the body region, neural crest cells also contribute the peripheral nervous system (both neurons and glia) consisting of sensory ganglia (dorsal root ganglia), sympathetic and parasympathetic ganglia and neural plexuses within specific tissues/organs.
In the head region, neural crest cells migrate into the pharyngeal arches (as shown in movie below) forming ectomesenchyme contributing tissues which in the body region are typically derived from mesoderm (cartilage, bone, and connective tissue).General neural development is also covered in Neural Notes.
Some Recent Findings
|More recent papers|
This table shows an automated computer PubMed search using the listed sub-heading term.
References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.
M C Guerrera, F Abbate, G Di Caro, G P Germanà, M Levanti, V Micale, G Montalbano, R Laurà, A Germanà, U Muglia Localization of cholecystokinin in the zebrafish retina from larval to adult stage. Ann. Anat.: 2018; PubMed 29679719
Hanane Touil, Antonia Kobert, Nathalie Lebeurrier, Aja Rieger, Philippe Saikali, Caroline Lambert, Lama Fawaz, Craig S Moore, Alexandre Prat, Jennifer Gommerman, Jack P Antel, Yasuto Itoyama, Ichiro Nakashima, Amit Bar-Or, Canadian B Cell Team in MS Human central nervous system astrocytes support survival and activation of B cells: implications for MS pathogenesis. J Neuroinflammation: 2018, 15(1);114 PubMed 29673365
Tatsuya Ishikawa, Kei Eto, Sun Kwang Kim, Hiroaki Wake, Ikuko Takeda, Hiroshi Horiuchi, Andrew J Moorhouse, Hitoshi Ishibashi, Junichi Nabekura Cortical astrocytes prime the induction of spine plasticity and mirror image pain. Pain: 2018; PubMed 29672449
Tyler A Vahedi-Hunter, Jason A Estep, Kylee A Rosette, Michael L Rutlin, Kevin M Wright, Martin M Riccomagno Cas Adaptor Proteins Coordinate Sensory Axon Fasciculation. Sci Rep: 2018, 8(1);5996 PubMed 29662228
H-G Schaible, H-D Chang, S Grässel, H Haibel, A Hess, T Kamradt, A Radbruch, G Schett, C Stein, R H Straub [Research consortium Neuroimmunology and pain in the research network musculoskeletal diseases]. [Forschungsverbund Neuroimmunologie und Schmerz (Neuroimpa) im Forschungsnetz Muskuloskelettale Erkrankungen.] Z Rheumatol: 2018; PubMed 29654392
Ramazan Üstün, Elif Kaval Oğuz Degenerative effect of Ankaferd Blood Stopper® on mice peripheral sensory neurons in vitro. Folia Neuropathol: 2018, 56(1);67-74 PubMed 29663742
Mahtab Mojtahed Zadeh, Amir Ashraf-Ganjouei, Farzaneh Ghazi Sherbaf, Maryam Haghshomar, Mohammad Hadi Aarabi White Matter Tract Alterations in Drug-Naïve Parkinson's Disease Patients With Impulse Control Disorders. Front Neurol: 2018, 9;163 PubMed 29662464
Agnieszka M Jurga, Ewelina Rojewska, Wioletta Makuch, Joanna Mika Lipopolysaccharide from Rhodobacter sphaeroides (TLR4 antagonist) attenuates hypersensitivity and modulates nociceptive factors. Pharm Biol: 2018, 56(1);275-286 PubMed 29656686
Hui Chen, Jianping Xiang, Junxia Wu, Bo He, Tao Lin, Qingtang Zhu, Xiaolin Liu, Canbin Zheng Expression patterns and role of PTEN in rat peripheral nerve development and injury. Neurosci. Lett.: 2018; PubMed 29649487
Caleb W Grote, Natalie M Wilson, Natalie K Katz, Brianne L Guilford, Janelle M Ryals, Lesya Novikova, Lisa Stehno-Bittel, Douglas E Wright Deletion of the insulin receptor in sensory neurons increases pancreatic insulin levels. Exp. Neurol.: 2018; PubMed 29649429
Xinping Yue, Tyler M Basting, Thomas W Flanagan, Jiaxi Xu, Thomas D Lobell, Nicholas W Gilpin, Jason D Gardner, Eric Lazartigues Nicotine Downregulates the Compensatory Angiotensin-Converting Enzyme 2/Angiotensin Type 2 Receptor of the Renin-Angiotensin System. Ann Am Thorac Soc: 2018, 15(Supplement_2);S126-S127 PubMed 29676623
Quin E Denfeld, Beth A Habecker, William R Woodward Measurement of plasma norepinephrine and 3,4-dihydroxyphenylglycol: method development for a translational research study. BMC Res Notes: 2018, 11(1);248 PubMed 29673396
David Macias, Andrew S Cowburn, Hortensia Torres-Torrelo, Patricia Ortega-Sáenz, José López-Barneo, Randall Johnson HIF-2α is essential for carotid body development and function. Elife: 2018, 7; PubMed 29671738
Jessica W Y Yuen, David D Kim, Ric M Procyshyn, Randall F White, William G Honer, Alasdair M Barr Clozapine-Induced Cardiovascular Side Effects and Autonomic Dysfunction: A Systematic Review. Front Neurosci: 2018, 12;203 PubMed 29670504
Hui Zhou, Baojun Shi, Yitao Jia, Gang Qiu, Weiguang Yang, Jiali Li, Zhaolong Zhao, Jian Lv, Yanni Zhang, Zhongxin Li Expression and significance of autonomic nerves and α9 nicotinic acetylcholine receptor in colorectal cancer. Mol Med Rep: 2018; PubMed 29658602
Neural Crest Migration
Movie Source: Original Neural Crest movies kindly provided by Paul Kulesa.
The following cranial and trunk data is based upon 185 serially sectioned staged (Carnegie) human embryos.
Cranial Neural Crest
- stage 9 - an indication of mesencephalic neural crest
- stage 10 - trigeminal, facial, and postotic components
- stage 11 - crest-free zones are soon observable in rhombomere 1, 3, and 5
- stage 12 - rhombomeres 6 and 7 neural crest migrate to pharyngeal arch 3 and then rostrad to the truncus arteriosus
- stage 13 - nasal crest and the terminalis-vomeronasal complex are last of the cranial crest to appear
stages 9-14 - otic vesicle primordium descends
Trunk Neural Crest
Spinal ganglia increase in number over time and are in phase with the somites, though not their centre. There are 3 migratory pathways: ventrolateral between dermatomyotome and sclerotome, ventromedial between neural tube and sclerotomes, and lateral between surface ectoderm and dermatomyotome.
- stage 13 - about 19 present
- stage 14 - about 33 present
- stage 15-23 - 30–35 ganglia
- Vukojevic K, Filipovic N, Tica Sedlar I, Restovic I, Bocina I, Pintaric I & Saraga-Babic M. (2016). Neuronal differentiation in the developing human spinal ganglia. Anat Rec (Hoboken) , 299, 1060-72. PMID: 27225905 DOI.
- Hu ZL, Shi M, Huang Y, Zheng MH, Pei Z, Chen JY, Han H & Ding YQ. (2011). The role of the transcription factor Rbpj in the development of dorsal root ganglia. Neural Dev , 6, 14. PMID: 21510873 DOI.
- Kulesa PM, Bailey CM, Kasemeier-Kulesa JC & McLennan R. (2010). Cranial neural crest migration: new rules for an old road. Dev. Biol. , 344, 543-54. PMID: 20399765 DOI.
- Kulesa PM & Fraser SE. (2000). In ovo time-lapse analysis of chick hindbrain neural crest cell migration shows cell interactions during migration to the branchial arches. Development , 127, 1161-72. PMID: 10683170
- O'Rahilly R & Müller F. (2007). The development of the neural crest in the human. J. Anat. , 211, 335-51. PMID: 17848161 DOI.
Chen HH, Hippenmeyer S, Arber S & Frank E. (2003). Development of the monosynaptic stretch reflex circuit. Curr. Opin. Neurobiol. , 13, 96-102. PMID: 12593987
Schober A & Unsicker K. (2001). Growth and neurotrophic factors regulating development and maintenance of sympathetic preganglionic neurons. Int. Rev. Cytol. , 205, 37-76. PMID: 11336393
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Cite this page: Hill, M.A. (2018, April 25) Embryology Neural Crest - Peripheral Nervous System. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Neural_Crest_-_Peripheral_Nervous_System
- © Dr Mark Hill 2018, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G