Neural Crest - Peripheral Nervous System
|Embryology - 18 Jun 2018 Expand to Translate|
|Google Translate - select your language from the list shown below (this will open a new external page)|
العربية | català | 中文 | 中國傳統的 | français | Deutsche | עִברִית | हिंदी | bahasa Indonesia | italiano | 日本語 | 한국어 | မြန်မာ | Pilipino | Polskie | português | ਪੰਜਾਬੀ ਦੇ | Română | русский | Español | Swahili | Svensk | ไทย | Türkçe | اردو | ייִדיש | Tiếng Việt These external translations are automated and may not be accurate. (More? About Translations)
The neural crest are bilaterally paired strips of cells arising in the ectoderm at the margins of the neural tube. These cells migrate to many different locations and differentiate into many cell types within the embryo. This means that many different systems (neural, skin, teeth, head, face, heart, adrenal glands, gastrointestinal tract) will also have a contribution fron the neural crest cells.
In the body region, neural crest cells also contribute the peripheral nervous system (both neurons and glia) consisting of sensory ganglia (dorsal root ganglia), sympathetic and parasympathetic ganglia and neural plexuses within specific tissues/organs.
In the head region, neural crest cells migrate into the pharyngeal arches (as shown in movie below) forming ectomesenchyme contributing tissues which in the body region are typically derived from mesoderm (cartilage, bone, and connective tissue).General neural development is also covered in Neural Notes.
Some Recent Findings
|More recent papers|
This table shows an automated computer PubMed search using the listed sub-heading term.
References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.
Yuki Miyamoto, Tomohiro Torii, Masashi Inoue, Takako Morimoto, Masahiro Yamamoto, Junji Yamauchi Data on the effect of knockout of neruregulin-1 type III on Remak bundle structure. Data Brief: 2018, 18;803-807 PubMed 29900241
Serena Stanga, Liliana Brambilla, Bernadette Tasiaux, Anh H Dang, Adrian Ivanoiu, Jean-Noël Octave, Daniela Rossi, Vincent van Pesch, Pascal Kienlen-Campard A Role for GDNF and Soluble APP as Biomarkers of Amyotrophic Lateral Sclerosis Pathophysiology. Front Neurol: 2018, 9;384 PubMed 29899726
Yanqing Wu, Zhouguang Wang, Pingtao Cai, Ting Jiang, Yiyang Li, Yuan Yuan, Rui Li, Sinan Khor, Yingfeng Lu, Jian Wang, Daqing Chen, Qiqiang Zeng, Ruisheng Zhong, Hongyu Zhang, Yuan Lin, Xiaokun Li, Jian Xiao Dual Delivery of bFGF- and NGF-Binding Coacervate Confers Neuroprotection by Promoting Neuronal Proliferation. Cell. Physiol. Biochem.: 2018, 47(3);948-956 PubMed 29895019
Marc Ferrer, Sara J C Gosline, Marigo Stathis, Xiaohu Zhang, Xindi Guo, Rajarshi Guha, Dannielle A Ryman, Margaret R Wallace, Laura Kasch-Semenza, Haiping Hao, Roxann Ingersoll, David Mohr, Craig Thomas, Sharad Verma, Justin Guinney, Jaishri O Blakeley Pharmacological and genomic profiling of neurofibromatosis type 1 plexiform neurofibroma-derived schwann cells. Sci Data: 2018, 5;180106 PubMed 29893754
Morgane Sonia Thion, Sandrine Humbert Cancer: From Wild-Type to Mutant Huntingtin. J Huntingtons Dis: 2018; PubMed 29889077
Ryan A Mischel, William L Dewey, Hamid I Akbarali Tolerance to Morphine-Induced Inhibition of TTX-R Sodium Channels in Dorsal Root Ganglia Neurons Is Modulated by Gut-Derived Mediators. iScience: 2018, 2;193-209 PubMed 29888757
Nitesh P Patel, Kristopher A Lyon, Jason H Huang An update-tissue engineered nerve grafts for the repair of peripheral nerve injuries. Neural Regen Res: 2018, 13(5);764-774 PubMed 29862995
Fu-Chen Yang, Julia Draper, Peter G Smith, Jay L Vivian, Steven M Shapiro, John A Stanford Short Term Development and Fate of MGE-Like Neural Progenitor Cells in Jaundiced and Non-Jaundiced Rat Brain. Cell Transplant: 2018;963689718766327 PubMed 29845869
Serena Viventi, Mirella Dottori Modelling the Dorsal Root Ganglia using Human Pluripotent Stem Cells: A Platform to Study Peripheral Neuropathies. Int. J. Biochem. Cell Biol.: 2018; PubMed 29772357
Rachel M Bailey, Diane Armao, Sahana Nagabhushan Kalburgi, Steven J Gray Development of Intrathecal AAV9 Gene Therapy for Giant Axonal Neuropathy. Mol Ther Methods Clin Dev: 2018, 9;160-171 PubMed 29766026
S Obernikhin, N Yaglova, D Tsomartova, V Torbek, M Ivanova [EPIGENETIC REGULATION OF ADRENAL CHROMAFFIN CELLS DEVELOPMENT (REVIEW)]. Georgian Med News: 2018, (278);138-146 PubMed 29905560
Yasuyuki Fujii, Kenta Suzuki, Yahiro Hasegawa, Fumio Nanba, Toshiya Toda, Takahiro Adachi, Shu Taira, Naomi Osakabe Single oral administration of flavan 3-ols induces stress responses monitored with stress hormone elevations in the plasma and paraventricular nucleus. Neurosci. Lett.: 2018; PubMed 29902479
Javeria N Syeda, Ian H Rutkofsky, Adnan S Muhammad, Tarig H Balla Abdalla, Zahid Saghir The Psycho-cardiac Coupling, Myocardial Remodeling, and Neuroendocrine Factor Levels: The Psychosomatics of Major Depressive Disorder. Cureus: 2018, 10(4);e2464 PubMed 29900084
Mario A Inchiosa Anti-tumor activity of phenoxybenzamine and its inhibition of histone deacetylases. PLoS ONE: 2018, 13(6);e0198514 PubMed 29897996
Andreas M Weng, Stefan Wilimsky, Gwendolyn Bender, Stefanie Hahner, Herbert Köstler, Christian O Ritter Magnetic resonance cold pressor test to investigate potential endothelial dysfunction in patients suffering from type 1 diabetes. J Magn Reson Imaging: 2018; PubMed 29897641
Neural Crest Migration
Movie Source: Original Neural Crest movies kindly provided by Paul Kulesa.
The following cranial and trunk data is based upon 185 serially sectioned staged (Carnegie) human embryos.
Cranial Neural Crest
- stage 9 - an indication of mesencephalic neural crest
- stage 10 - trigeminal, facial, and postotic components
- stage 11 - crest-free zones are soon observable in rhombomere 1, 3, and 5
- stage 12 - rhombomeres 6 and 7 neural crest migrate to pharyngeal arch 3 and then rostrad to the truncus arteriosus
- stage 13 - nasal crest and the terminalis-vomeronasal complex are last of the cranial crest to appear
stages 9-14 - otic vesicle primordium descends
Trunk Neural Crest
Spinal ganglia increase in number over time and are in phase with the somites, though not their centre. There are 3 migratory pathways: ventrolateral between dermatomyotome and sclerotome, ventromedial between neural tube and sclerotomes, and lateral between surface ectoderm and dermatomyotome.
- stage 13 - about 19 present
- stage 14 - about 33 present
- stage 15-23 - 30–35 ganglia
- Vukojevic K, Filipovic N, Tica Sedlar I, Restovic I, Bocina I, Pintaric I & Saraga-Babic M. (2016). Neuronal differentiation in the developing human spinal ganglia. Anat Rec (Hoboken) , 299, 1060-72. PMID: 27225905 DOI.
- Hu ZL, Shi M, Huang Y, Zheng MH, Pei Z, Chen JY, Han H & Ding YQ. (2011). The role of the transcription factor Rbpj in the development of dorsal root ganglia. Neural Dev , 6, 14. PMID: 21510873 DOI.
- Kulesa PM, Bailey CM, Kasemeier-Kulesa JC & McLennan R. (2010). Cranial neural crest migration: new rules for an old road. Dev. Biol. , 344, 543-54. PMID: 20399765 DOI.
- Kulesa PM & Fraser SE. (2000). In ovo time-lapse analysis of chick hindbrain neural crest cell migration shows cell interactions during migration to the branchial arches. Development , 127, 1161-72. PMID: 10683170
- O'Rahilly R & Müller F. (2007). The development of the neural crest in the human. J. Anat. , 211, 335-51. PMID: 17848161 DOI.
Chen HH, Hippenmeyer S, Arber S & Frank E. (2003). Development of the monosynaptic stretch reflex circuit. Curr. Opin. Neurobiol. , 13, 96-102. PMID: 12593987
Schober A & Unsicker K. (2001). Growth and neurotrophic factors regulating development and maintenance of sympathetic preganglionic neurons. Int. Rev. Cytol. , 205, 37-76. PMID: 11336393
External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Cite this page: Hill, M.A. (2018, June 18) Embryology Neural Crest - Peripheral Nervous System. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Neural_Crest_-_Peripheral_Nervous_System
- © Dr Mark Hill 2018, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G