File:Spinal cord delta notch model.png

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Spinal Cord - Delta-Notch Signalling Model (chicken)

Model of the embryonic rostro-caudal gradient of neurogenesis along the prospective spinal cord from the stem zone to the neurogenic neural tube summarising the cellular processes that seem to occur during the transition from proliferation to neurogenesis and how DELTA-NOTCH signalling may be involved in these processes.

  • As a consequence of the caudal to rostral decreasing FGF gradient, Delta-1 expression decreases in those cells that leave the stem zone (light blue) and move into the PNTZ where they intermingle with cells that do not express Delta-1.

  • This can generate differences in DELTA/NOTCH signalling between adjacent cells that may initiate lateral inhibition.

  • This results in the upregulation of Delta-1 in single NP cells which signal (blue arrows) and activate NOTCH signalling in adjacent cells, which as a consequence express Hes5 and are maintained in a proliferating state.

  • Subsequently, the Delta-1 expressing NP cell divides into two cells that express Tis21.

  • These double Delta-1/Tis21 labelled NP down regulate the expression of Delta-1 as they reach the NZ and begin to divide in a neurogenic manner.

  • One of the daughter cells upregulates Delta-1 expression and differentiates as a neuron while the other one, which receives NOTCH signalling (blue arrows), remains as neurogenic NP. Hensen node (HN), neural tube (NT), neurogenic zone (NZ), proliferation to neurogenesis transition zone (PNTZ), presomitic territory (PS), somite (S).

Links: Chicken Development | Neural - Spinal Cord Development

Notch Links: Notch structure cartoon | Notch signaling pathway cartoon | Notch and signaling pathway cartoon | Developmental Signals - Notch | Molecular Factors


Hämmerle B & Tejedor FJ. (2007). A novel function of DELTA-NOTCH signalling mediates the transition from proliferation to neurogenesis in neural progenitor cells. PLoS ONE , 2, e1169. PMID: 18000541 DOI.


© 2007 Hämmerle, Tejedor. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Citation: Hämmerle B, Tejedor FJ (2007) A Novel Function of DELTA-NOTCH Signalling Mediates the Transition from Proliferation to Neurogenesis in Neural Progenitor Cells. PLoS ONE 2(11): e1169. doi:10.1371/journal.pone.0001169


Cite this page: Hill, M.A. (2024, May 28) Embryology Spinal cord delta notch model.png. Retrieved from

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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current11:58, 12 August 2009Thumbnail for version as of 11:58, 12 August 2009599 × 457 (171 KB)MarkHill (talk | contribs)Figure 9. A working model for the involvement of DELTA-NOTCH signalling in the transition from proliferation to neurogenesis in the developing chick spinal cord. Schematic model of the embryonic rostro-caudal gradient of neurogenesis along the prospectiv

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