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(Osteoclasts Very large (up to 100 µm), multi-nucleated (about 5-10 visible in a histological section, but up to 50 in the actual cell) bone-resorbing cells. They arise by the fusion of monocytes (macrophage precursors in the blood) or macrophages. Oste)
 
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Osteoclasts
==Osteoclast==


Very large (up to 100 µm), multi-nucleated (about 5-10 visible in a histological section, but up to 50 in the actual cell) bone-resorbing cells.
Very large (up to 100 µm), multi-nucleated (about 5-10 visible in a histological section, but up to 50 in the actual cell) bone-resorbing cells.


They arise by the fusion of monocytes (macrophage precursors in the blood) or macrophages. Osteoclasts attach themselves to the bone matrix and form a tight seal at the rim of the attachment site. The cell membrane opposite the matrix has deep invaginations forming a ruffled border. Osteoclasts empty the contents of lysosomes into the extracellular space between the ruffled border and the bone matrix. The released enzymes break down the collagen fibres of the matrix. Osteoclasts are stimulated by parathyroid hormone (produced by the parathyroid gland) and inhibited by calcitonin (produced by specialised cells of the thyroid gland). Osteoclasts are often seen within the indentations of the bone matrix that are formed by their activity (resorption bays or Howship's lacunae).
* Cells arise by the fusion of [[M#monocyte|monocytes]] (macrophage precursors in the blood) or [[M#macrophage|macrophages]].  
* Osteoclasts attach themselves to the bone matrix and form a tight seal at the rim of the attachment site.  
* The cell membrane opposite the matrix has deep invaginations forming a ruffled border.  
* Osteoclasts empty the contents of lysosomes into the extracellular space between the ruffled border and the bone matrix.  
* The released enzymes break down the collagen fibres of the matrix.  
* Osteoclasts are stimulated by parathyroid hormone (produced by the parathyroid gland)
* Osteoclasts are inhibited by calcitonin (produced by specialised cells of the thyroid gland).  
* Osteoclasts are often seen lying over the indentations of the bone matrix that are formed by their activity (resorption bays or [[H#Howship.27s_lacuna|Howship's lacunae]]).
 
 
{{Bone Histology}}
 
 
{{Blue Histology}}
 


Original File Name: Ocl41he.jpg
Original File Name: Ocl41he.jpg
[[Category:Musculoskeletal]] [[Category:Histology]] [[Category:Bone]]

Latest revision as of 14:43, 18 February 2013

Osteoclast

Very large (up to 100 µm), multi-nucleated (about 5-10 visible in a histological section, but up to 50 in the actual cell) bone-resorbing cells.

  • Cells arise by the fusion of monocytes (macrophage precursors in the blood) or macrophages.
  • Osteoclasts attach themselves to the bone matrix and form a tight seal at the rim of the attachment site.
  • The cell membrane opposite the matrix has deep invaginations forming a ruffled border.
  • Osteoclasts empty the contents of lysosomes into the extracellular space between the ruffled border and the bone matrix.
  • The released enzymes break down the collagen fibres of the matrix.
  • Osteoclasts are stimulated by parathyroid hormone (produced by the parathyroid gland)
  • Osteoclasts are inhibited by calcitonin (produced by specialised cells of the thyroid gland).
  • Osteoclasts are often seen lying over the indentations of the bone matrix that are formed by their activity (resorption bays or Howship's lacunae).


Bone Histology: Cartilage Histology | Histology Stains | Histology | cartilage | bone | bone timeline
Compact bone Compact canals | Compact lamellae | compact bone - low unstained | compact bone - high unstained | compact bone - high unstained | compact - low | compact - low | compact - med | compact - high |
Trabecular bone trabecular | lamellar | trabecular - overview HE | trabecular - low HE | trabecular - med HE
Endochondral ossification primary ossification | endochondral ossification
Intramembranous ossification intramembranous - VG low | intramembranous - VG high | intramembranous - HE low | intramembranous - HE high


Links: Histology | Histology Stains | Blue Histology images copyright Lutz Slomianka 1998-2009. The literary and artistic works on the original Blue Histology website may be reproduced, adapted, published and distributed for non-commercial purposes. See also the page Histology Stains.

Cite this page: Hill, M.A. (2024, May 28) Embryology Osteoclast.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Osteoclast.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G


Original File Name: Ocl41he.jpg

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current14:37, 18 February 2013Thumbnail for version as of 14:37, 18 February 2013500 × 333 (41 KB)Z8600021 (talk | contribs)increased image size and adjusted contrast.
11:28, 11 September 2009Thumbnail for version as of 11:28, 11 September 2009300 × 200 (21 KB)S8600021 (talk | contribs)Osteoclasts Very large (up to 100 µm), multi-nucleated (about 5-10 visible in a histological section, but up to 50 in the actual cell) bone-resorbing cells. They arise by the fusion of monocytes (macrophage precursors in the blood) or macrophages. Oste

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