BGDA Practical 7 - Week 8

Introduction

Key Events of Human Development during the eighth week (week 8) following fertilization or Clinical week 10 (LMP).

This page will give an overview of limb and neural development and look at other system organization compared with the earlier stages.

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  Stage 20

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  Stage 21

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  Stage 22

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  Stage 23

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  Stage 20 - right

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  Stage 20 - ventral

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  Stage 20 - left

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  Stage 21 - right

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  Stage 21 - ventral

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  Stage 21 - left

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  Stage 22 - right

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  Stage 22 - ventral

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  Stage 22 - left

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  Stage 23 - right

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  Stage 23 - ventral

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  Stage 22 - left

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  Stage 22 - dorsal

Limbs

Human Embryo (Stage19) limb rotation

• Limb upper and lower limbs rotate in different directions (upper limb dorsally, lower limb ventrally)
• see also Adult dermatomes

Gastrointestinal Tract

Gastrointestinal tract herniation

Neural

Cortex development commences Ventricular layer (stem cells) proliferate. Differentiating cells migrate away from ventricular layer.

Other Embryo Systems

Movies - Embryo Carnegie stage 22 - These are rotating animations based upon reconstruction of a human embryo (stage 22) serial slice images.

Cardiovascular	Skeletal	Urogenital

Critical Periods

Conceptus		Embryonic development (weeks)													Fetal period (weeks)
1	2	3		4			5	6		7		8			9		16	20-36	38
		Neural
			Heart
				Upper limbs
					Lower limbs
					Ear
						Eye
									Palate
									Teeth
											External genitalia
Loss		Major abnormalities										Functional and Minor abnormalities

   

Additional Information

Additional Information - Content shown under this heading is not part of the material covered in this class. It is provided for those students who would like to know about some concepts or current research in topics related to the current class page.

Detailed Week by Week

The following information is a detailed timeline of embryonic development between week 3 to 8 and content does not form part of the current practical class.

Week 3 | Week 4 | Week 5 | Week 6 | Week 7 | Week 8

Embryo Stages and Events

Day	Stage	Event
50	Stage 20	Head scalp vascular plexus visible Limb upper limbs begin to rotate ventrally Neural - amygdaloid body has at least four individual nuclei oculomotor nerve shows a dorsolateral and a ventromedial portion rhombic lip (rhombencephalon) formation of the cerebellum (intermediate layer) and of the cochlear nuclei cerebellum cell layer (future Purkinje cells) develops choroid plexuses of the fourth and lateral ventricles
51		Gastrointestinal Tract anal (cloacal) membrane perforates
52	Stage 21	Neural - cortical plate appears in the area of future insula Limb upper and lower limbs rotate Intraembryonic Coelom pericardioperitoneal canals close
53
54	Stage 22	Neural - neocortical fibres project to epithalamus, to dorsal thalamus, and to mesencephalon Limb fingers and toes lengthen Sense - Smell Stage 22 to early fetal period - migratory streams of neurons from the subventricular zone of the olfactory bulb towards the future claustrum
55		Genital 8 Weeks Testis - mesenchyme, interstitial cells (of Leydig) secrete testosterone, androstenedione Genital 8 to 12 Weeks - hCG stimulates testosterone production Tongue Week 8 - nerves penetrate epitheilai basal lamina and synapse with undifferentiated, elongated, epithelial cells (taste bud progenitor cell)
56	Stage 23	Stage 23 defines the end of the embryonic (organogenesis) period Mesoderm heart prominence, ossification continues Head nose, eye, external acoustic meatus, eyelids, external ears, rounded head Body - straightening of trunk, heart, liver, umbilical cord, intestines herniated at umbilicus Limb upper limbs longer and bent at elbow, hands and feet turned inward, foot with separated digits, wrist, hand with separated digits Extraembryonic Coelom chorionic cavity is now lost by fusion with the expanding amniotic cavity Neural - rhombencephalon, pyramidal decussation present, nuclei and tracts similar to those present in the newborn cerebellum present as only a plate connected to midbrain and hindbrain through fibre bundles Axial Skeleton vertebral column 33 or 34 cartilaginous vertebrae (20-33 mm in total length), vertebral pedicles, articular and transverse processes identifiable (no spinous processes)
	Week 8	Stomach - Week 8 - Gastrin containing cells in stomach antrum. Somatostatin cells in both the antrum and the fundus.