Abnormal Development - Fetal Alcohol Syndrome Mouse Model: Difference between revisions
mNo edit summary |
|||
(2 intermediate revisions by one other user not shown) | |||
Line 1: | Line 1: | ||
{{Header}} | |||
==Introduction== | ==Introduction== | ||
Line 6: | Line 7: | ||
:'''Links:''' [[Abnormal_Development_-_Fetal_Alcohol_Syndrome|Fetal Alcohol Syndrome]] | [[Mouse Development]] | [[Mouse Timeline Detailed]] | :'''Links:''' [[Abnormal_Development_-_Fetal_Alcohol_Syndrome|Fetal Alcohol Syndrome]] | [[Mouse Development]] | [[Mouse Timeline Detailed]] | ||
==Some Recent Findings== | |||
{| | |||
|-bgcolor="F5FAFF" | |||
| | |||
* '''Cardiac birth defects in mice and prevention with folate'''<ref><pubmed>20451895</pubmed></ref> "Pregnant mice on embryonic day 6.75 during gastrulation were exposed by an intraperitoneal injection to a binge-drinking dose of ethanol. Folic acid supplementation of mouse diet was tested for the prevention of ethanol-induced cardiac birth defects. RESULTS: Acute ethanol exposure induced myocardial wall changes and atrioventricular and semilunar valve defects, which was determined by echocardiography on embryonic day 15.5. A high folate diet prevented the ethanol-induced cardiac defects. Ethanol exposure in avian embryos suppressed 2 key Wnt-modulated genes that are involved in cardiac induction; folic acid rescued normal gene expression. CONCLUSION: Folic acid supplementation alone or with myoinositol prevented alcohol potentiation of Wnt/beta-catenin signaling that allowed normal gene activation and cardiogenesis." (More? [[Abnormal_Development_-_Folic_Acid_and_Neural_Tube_Defects|Folic Acid and Neural Tube Defects]]) | |||
* '''Maternal ethanol consumption alters the epigenotype and the phenotype of offspring in a mouse model.'''<ref name="PMID20084100"><pubmed>20084100</pubmed> | [http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1000811 PLoS]</ref> "Our work raises the possibility of a role for epigenetics in the etiology of fetal alcohol spectrum disorders, and it provides a mouse model that will be a useful resource in the continued efforts to understand the consequences of gestational alcohol exposure at the molecular level." | |||
* '''Magnetic resonance microscopy defines ethanol-induced brain abnormalities in prenatal mice'''<ref><pubmed>19302087</pubmed>| [http://www3.interscience.wiley.com/journal/122268272/abstract Alcoholism: Clinical and Experimental Research]</ref> "This study demonstrates that exposure to ethanol occurring in mice at stages corresponding to the human fourth week postfertilization results in structural brain abnormalities that are readily identifiable at fetal stages of development." (More? [[Magnetic Resonance Imaging]]) | |||
|} | |||
{| | |||
| [[File:Mouse_maternal_ethanol_skull_effects.png|600px]] | |||
|- | |||
| Variable midfacial dysmorphism and microcephaly in a/a offspring of mothers that consumed ethanol during gestation<ref name="PMID20084100" /> | |||
|} | |||
==References== | ==References== | ||
Line 15: | Line 32: | ||
==External Links== | ==External Links== | ||
{{External Links}} | |||
* [http://www.med.unc.edu/alcohol/sulik.html Bowles Center for Alcohol Studies at the University of North Carolina at Chapel Hill] | * [http://www.med.unc.edu/alcohol/sulik.html Bowles Center for Alcohol Studies at the University of North Carolina at Chapel Hill] | ||
Line 21: | Line 40: | ||
{{Footer}} | {{Footer}} | ||
[[Category:Environmental Abnormalities]] [[Category:Abnormal Development]] [[Category:Mouse]] |
Latest revision as of 14:56, 8 September 2016
Embryology - 27 Apr 2024 Expand to Translate |
---|
Google Translate - select your language from the list shown below (this will open a new external page) |
العربية | català | 中文 | 中國傳統的 | français | Deutsche | עִברִית | हिंदी | bahasa Indonesia | italiano | 日本語 | 한국어 | မြန်မာ | Pilipino | Polskie | português | ਪੰਜਾਬੀ ਦੇ | Română | русский | Español | Swahili | Svensk | ไทย | Türkçe | اردو | ייִדיש | Tiếng Việt These external translations are automated and may not be accurate. (More? About Translations) |
Introduction
Some Recent Findings
|
Variable midfacial dysmorphism and microcephaly in a/a offspring of mothers that consumed ethanol during gestation[2] |
References
Search Pubmed: Mouse Fetal Alcohol Syndrome | Sulik K
External Links
External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.
Glossary Links
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Cite this page: Hill, M.A. (2024, April 27) Embryology Abnormal Development - Fetal Alcohol Syndrome Mouse Model. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Abnormal_Development_-_Fetal_Alcohol_Syndrome_Mouse_Model
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G