Talk:Stem Cells - Placental Cord Blood
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Cite this page: Hill, M.A. (2024, June 23) Embryology Stem Cells - Placental Cord Blood. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Talk:Stem_Cells_-_Placental_Cord_Blood |
Original UNSW Embryology Pages: Stem Cells | Stem Cell Ethics | Cord Blood | Adult Stem Cells | Neural Stem Cells | Week 2 Stem Cells | Cloning
2012
Trends in cord blood banking
Blood Transfus. 2012 Jan;10(1):95-100. doi: 10.2450/2011.0032-11. Epub 2011 Nov 15.
Arrojo IP, Lamas Mdel C, Verdugo LP, Alfaro PR, Pena RR, Gordo FS, Maldonado PG, Gémar GG. Source Andalusian Cord Blood Bank, Regional Blood Transfusion Centre, Malaga, Spain. isidro.prat.sspa@juntadeandalucia.es
Abstract
BACKGROUND: Umbilical cord blood (UCB) is a source of hematopoietic precursor cells for transplantation. The creation of UCB banks in 1992 led to the possibility of storing units of UCB for unrelated transplants. The distribution of cell contents in historical inventories is not homogenous and many units are not, therefore, suitable for adults. The aim of this study was to analyse our UCB bank inventory, evaluate the units released for transplantation and calculate the cost of the current process per unit of UCB stored. METHODS: Three study periods were defined. In the first period, from January 1996 to January 2006, the total nucleated cell (TNC) count acceptable for processing was 4-6×10(8) and a manual processing system was used. In the second period, from October 2006 to July 2010, processing was automated and the acceptable TNC count varied from 8-10×10(8). In the third period, from January 2009 to June 2010, an automated Sepax-BioArchive procedure was used and the accepted initial TNC count was >10×10(8). Within each period the units were categorised according to various ranges of cryopreserved TNC counts in the units: A, >16.2×10(8); B1, from 12.5-16.1×10(8); B2, from 5.2-12.4×10(8); and C, <5.1×10(8). RESULTS: The third period is best representative of current practices, with homogenous TNC acceptance criteria and automated processing. In this period 15.7% of the units were category A and 25.5% were category B. Overall, the mean TNC count of units released for transplantation was 14×10(8) (range, 4.6×10(8) to 36.5×10(8)). The cost of the processed UCB in 2009 was 720.41 euros per unit. CONCLUSION: An UCB bank should store units of high-quality, in terms of the TNC count of units issued for transplantation, have a training programme to optimise the selection of donors prior to delivery, use similar volume reduction systems and homogenous recovery indices, express its indicators in the same units, use validated analytical techniques, and bear in mind ethnic minorities.
PMID 22153685
2011
Umbilical cord blood: current status & promise for the future
Indian J Med Res. 2011 Sep;134:261-9. McKenna D, Sheth J. Source Foundation for Research in Genetics & Endocrinology, Ahmedabad, India.
Abstract
Umbilical cord blood (UCB) has been shown to be a suitable source of haematopoietic stem cells (HSCs) for haematopoietic reconstitution. An increase in the number of UCB transplants indicates an expansion of utility in a broad spectrum of disease conditions. Along with the advantages, UCB also has limitations, and hence several investigators are working to further optimize UCB for this use. Beyond haematopoietic transplantation, additional potential applications of UCB include immunotherapy, tissue engineering and regenerative medicine. UCB banking has improved with time largely due to involvement of professional organizations and their published standards. However, accreditation of these organizations remains voluntary, and in India three of ten banks are public with the remaining being private. Only one public and one private bank are American Association of Blood Banks (AABB) accredited in India. Government agencies need to provide regulatory and safety oversight, which is lacking in serveral countries. Public policy regarding UCB is in its infancy throughout most of the world. Ethical issues, including access to UCB banking and use as therapy for diseases other than haematological and metabolic disorders are in the early phase of trials and remain speculative.
PMID 21985808
2007
World's first public-private cord blood bank launched in UK (2007)[1] "The Virgin Health Bank will provide parents with the facility to store their child's umbilical cord blood in two portions - one as a private sample (about 80%) for the sole use of the child and his or her family and the second as a public sample (20%), available free of charge to anyone requiring stem cell transplantation."
- ↑ <pubmed>17289702</pubmed>|Virgin Health Bank
