Musculoskeletal Development

Introduction

This lecture is an introduction to the process of musculoskeletal development. In the body, this is mainly about mesoderm differentiation beginning with an embryonic connective tissue structure, the mesenchyme. In the head, this is a mixture of mesoderm and neural crest differentiation, from mesenchyme and ectomesenchyme respectively. The lecture will cover mainly cartilage and bone, as muscle will be covered in the limb lecture and in this week's laboratory.

Lecture Objectives

Understanding of mesoderm and neural crest development.
Understanding of connective tissue development.
Understanding of muscle, cartilage and bone development.
Understanding of the two forms of bone development.
Brief understanding of bone molecular development.
Brief understanding of other bone roles.
Brief understanding of bone abnormalities.

Textbook References

The Developing Human: Clinically Oriented Embryology (8th Edition) by Keith L. Moore and T.V.N Persaud - Moore & Persaud Chapter 15 the skeletal system
Larsen’s Human Embryology by GC. Schoenwolf, SB. Bleyl, PR. Brauer and PH. Francis-West - Chapter 11 Limb Dev (bone not well covered in this textbook)

Before we Are Born (5th ed.) Moore and Persaud Ch16,17: p379-397, 399-405
Essentials of Human Embryology Larson Ch11 p207-228

Early Development and Neural Derivatives

Abnormalities

References

Textbooks

The Developing Human: Clinically Oriented Embryology (8th Edition) by Keith L. Moore and T.V.N Persaud - Moore & Persaud Chapter Chapter 10 The Pharyngeal Apparatus pp201 - 240.
Larsen’s Human Embryology by GC. Schoenwolf, SB. Bleyl, PR. Brauer and PH. Francis-West - Chapter 12 Development of the Head, the Neck, the Eyes, and the Ears pp349 - 418.

Online Textbooks

Developmental Biology by Gilbert, Scott F. Sunderland (MA): Sinauer Associates, Inc.; c2000

Molecular Biology of the Cell Alberts, Bruce; Johnson, Alexander; Lewis, Julian; Raff, Martin; Roberts, Keith; Walter, Peter New York and London: Garland Science; c2002 Search Molecular Biology of the Cell Bone Is Continually Remodeled by the Cells Within It Image: Figure 22-52. Deposition of bone matrix by osteoblasts.Image: Figure 22-56. The development of a long bone.

Search

Bookshelf neural crest

Pubmed neural crest

UNSW Embryology Links

Notes: Bone Development | Limb Development | Axial Skeleton Development | Bone Development | Skull | Development Limb | Axial Skeleton| Human Bone | Endochondral Ossification | Skeletal Muscle | Cartilage | Joints

Lectures: ANAT2341 - Embryology 2008 - Lecture 16
Movies: Neural Movies

External Links

UWA Blue Histology Skeletal Tissues - Bone

University of Kansas Histoweb Bone

Loyola University Medical Education Network Part 9: Specialized Connective Tissue: Cartilage and Bone | Part 10: Endochondral Ossification

UNSW Embryology Cartilage and Bone

Glossary Links

Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link

Course Content 2009

Cite this page: Hill, M.A. (2024, June 3) Embryology 2009 Lecture 13. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/2009_Lecture_13

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