Notochord
Introduction
(axial mesoderm) The rod of cells lying in the midline of the trilaminar embryo mesoderm layer ventral to the neural tube. Thought to have at least 2 early roles in development and later roles in patterning surrounding tissues. 1. Mechanical, influencing the folding of the early embryo; 2. Morphogenic, secreting sonic hedgehog a protein which regulates the development of surrounding tissues (neural plate, somites, endoderm and other organs). In humans, the notochord forms in week 3 and is eventually lost during the formation of the vertebral column.
References
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<pubmed>16314867</pubmed> <pubmed>19206138</pubmed>
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Search NLM Online Textbooks: "Notochord" : Developmental Biology | The Cell- A molecular Approach | Molecular Biology of the Cell | Endocrinology
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Cite this page: Hill, M.A. (2024, June 18) Embryology Notochord. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Notochord
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G