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Swapping mitochondrial DNA in mammalian oocytes
Technique has the potential to prevent transmission of human mutated mitochondrial DNA from mother to baby.
Working with rhesus macaque monkeys, Tachibana et al.[1]:
- a - removed the nuclear material plus a cellular membrane (a karyoplast) from a mature oocyte, leaving behind its mitochondria. The nuclear material in the karyoplast consists of condensed chromosomes attached to thread-like spindle fibres (the spindle–chromosomal complex).
- b - transferred the karyoplast to an oocyte whose nucleus had been removed (a cytoplast).
- c - fused the karyoplast with the cytoplast and then fertilized the reconstructed oocyte.
- d - developing blastocyst was implanted in a surrogate mother.
- e - mother gave birth to a healthy baby.
Reference
- ↑ <pubmed>19710649</pubmed>
Nature 461, 354-355 (17 September 2009) | doi:10.1038/461354a; Published online 16 September 2009
Original Image Link: http://www.nature.com/nature/journal/v461/n7262/fig_tab/461354a_F1.html
Rightslink / Nature Publishing Group Order Details
Licensee: Mark A Hill
License Date: Sep 17, 2009
License Number: 2271631413678
Publication: Nature
Title: Developmental biology: Asexual healing
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