Stem Cells - Adult
Introduction
The term "stem cell" is now used widely to cover many different cells derived from both embryo and adult tissues.
A useful guide (online PDF document) to stem cells was produced in a report by the National Institute of Health (NIH, USA, May 2000) [../pdf/fullrptstem.pdf Stem Cells: A Primer] (note large size - 4.84 Mb) and more recently NIH has established a Stem Cell information page.
Some Recent Findings
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Induced Pluripotent Stem Cell
(iPS cell) A reprogrammed adult stem cell to form an embryonic stem cell, from which tissues or whole animals can develop. Can be generated by the expression of just four specific transcription factors.
Links: Nature Jul09 | ABC - Mice pups bred from adult stem cells
Bone Marrow Stem Cell
Bone marrow stromal stem cells
Hair Follicle Stem Cell
M. Sieber-Blum, M. Grim, Y.F. Hu, V. Szeder Pluripotent neural crest stem cells in the adult hair follicle. Dev Dyn. 2004 Oct;231(2):258-69.
Dental Pulp Stem Cell (DPSC)
Dental pulp stem/stromal cell (DPSC) are similar to bone marrow derived mesenchymal stem/stromal cells (hBMSCs) in the expression pattern of cell surface markers and their pluripotent differentiation capability.
Huang AH, Snyder BR, Cheng PH, Chan AW.Putative dental pulp-derived stem/stromal cells promote proliferation and differentiation of endogenous neural cells in the hippocampus of mice.Stem Cells. 2008 Oct;26(10):2654-63. Epub 2008 Aug 7.PMID: 18687995
Munoz JR, Stoutenger BR, Robinson AP, Spees JL, Prockop DJ.Human stem/progenitor cells from bone marrow promote neurogenesis of endogenous neural stem cells in the hippocampus of mice.Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18171-6. Epub 2005 Dec 5. Erratum in: Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):2000-2.PMID: 16330757
Gronthos S, Brahim J, Li W, Fisher LW, Cherman N, Boyde A, DenBesten P, Robey PG, Shi S.Stem cell properties of human dental pulp stem cells.J Dent Res. 2002 Aug;81(8):531-5.PMID: 12147742
Spermatogonial Stem Cell
Neural Stem Cell
In the adult brain, the subependymal zone (SEZ) (a thin layer of cells lining the lateral wall of the lateral brain ventricles) is a source of neural stem cells (NSCs).
Somatic Cell Nuclear Transfer
In 1996 Dolly the sheep was the first animal to be produced by somatic cell nuclear transfer (SCNT) using an adult-derived somatic cell as nuclear donor.
SCNT using a range of different cell types has been successfully applied to a range of species (cattle, mice, goats, pigs, cats, rabbits, horses, rats, dogs and ferrets. (see review[2])
Animal Timeline
References
Reviews
<pubmed>17157222</pubmed> <pubmed>17123233</pubmed> <pubmed>17076989</pubmed>
Articles
<pubmed>17282993</pubmed> <pubmed>17234930</pubmed>
Search PubMed
Search PubMed: Feb 2007 "adult stem cells" 811 reference articles of which 367 were reviews.
Search PubMed Now: adult stem cells | induced pluripotent stem cell |
Glossary Links
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Cite this page: Hill, M.A. (2024, June 20) Embryology Stem Cells - Adult. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Stem_Cells_-_Adult
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G