Developmental Mechanism - Epithelial Invagination: Difference between revisions
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==Introduction== | ==Introduction== | ||
Epithelia during development often undergo folding or invagination. In some cases the epithelial cells are eventually "pinched off" fron the existing epithelia to form a distinct structure, such as a tube or vesicle. For example this process occurs in neural tube formation, sensory placode (otic and optic vesicles). Changes in cell shape require changes in the actin cytoskeleton and recent researh has shown Rho1 a small GTPase of the Rho subfamily (Rho, Rac and Cdc42) which acts as regulatory switch for actin cytoskeleton is activated in epithelial cells for invagination process initiation. | Epithelia during development often undergo folding or invagination. In some cases the epithelial cells are eventually "pinched off" fron the existing epithelia to form a distinct structure, such as a tube or vesicle. For example this process occurs in neural tube formation, sensory placode (otic and optic vesicles). Changes in cell shape require changes in the actin cytoskeleton and recent researh has shown Rho1 a small GTPase of the Rho subfamily (Rho, Rac and Cdc42) which acts as regulatory switch for actin cytoskeleton is activated in epithelial cells for invagination process initiation. | ||
<center>'''''Mechanism''' - "a process, technique, or system for achieving a result".''</center> | <center>'''''Mechanism''' - "a process, technique, or system for achieving a result".''</center> | ||
{{Mechanism Links}} | |||
== Some Recent Findings == | == Some Recent Findings == | ||
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* <ref><pubmed></pubmed></ref> | * <ref name=PMID><pubmed></pubmed></ref> | ||
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! More recent papers | |||
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| [[File:Mark_Hill.jpg|90px|left]] {{Most_Recent_Refs}} | |||
Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Epithelial+Invagination ''Epithelial Invagination''] | |||
<pubmed limit=5>Epithelial Invagination</pubmed> | |||
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==Neural plate to Neural Groove== | |||
In week 3 ({{GA}} week 5) of human development, the ectodermal '''neural plate''' invaginated to form the '''neural groove'''. This is the first step in converting an epithelial sheet into an epithelial tube that will form the central nervous system. | |||
[[File:Stage10_sem6.jpg|alt=Human embryo stage 10 electron micrograph|600px]] | |||
:'''Links:''' [[Neural System Development]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 07:31, 10 July 2014
Embryology - 20 Aug 2026    Expand to Translate
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Introduction
Epithelia during development often undergo folding or invagination. In some cases the epithelial cells are eventually "pinched off" fron the existing epithelia to form a distinct structure, such as a tube or vesicle. For example this process occurs in neural tube formation, sensory placode (otic and optic vesicles). Changes in cell shape require changes in the actin cytoskeleton and recent researh has shown Rho1 a small GTPase of the Rho subfamily (Rho, Rac and Cdc42) which acts as regulatory switch for actin cytoskeleton is activated in epithelial cells for invagination process initiation.
Some Recent Findings
| More recent papers |
|---|
  This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Epithelial Invagination <pubmed limit=5>Epithelial Invagination</pubmed> |
Neural plate to Neural Groove
In week 3 (GA week 5) of human development, the ectodermal neural plate invaginated to form the neural groove. This is the first step in converting an epithelial sheet into an epithelial tube that will form the central nervous system.
- Links: Neural System Development
References
- ↑ <pubmed></pubmed>
Textbooks
Reviews
<pubmed></pubmed>
Articles
Search PubMed
Search Pubmed: Endocrine Development
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Cite this page: Hill, M.A. (2026, August 20) Embryology Developmental Mechanism - Epithelial Invagination. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Mechanism_-_Epithelial_Invagination
- © Dr Mark Hill 2026, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
