Revision as of 09:50, 11 September 2009

Musculoskeletal Development

Introduction

This lecture is an introduction to the process of musculoskeletal development. In the body, this is mainly about mesoderm differentiation beginning with an embryonic connective tissue structure, the mesenchyme. In the head, this is a mixture of mesoderm and neural crest differentiation, from mesenchyme and ectomesenchyme respectively. The lecture will cover mainly cartilage and bone, as muscle will be covered in the limb lecture and in this week's laboratory.

Lecture Objectives

Understanding of mesoderm and neural crest development.
Understanding of connective tissue development.
Understanding of muscle, cartilage and bone development.
Understanding of the two forms of bone development.
Brief understanding of bone molecular development.
Brief understanding of other bone roles.
Brief understanding of bone abnormalities.

Textbook References

The Developing Human: Clinically Oriented Embryology (8th Edition) by Keith L. Moore and T.V.N Persaud - Moore & Persaud Chapter 15 the skeletal system
Larsen’s Human Embryology by GC. Schoenwolf, SB. Bleyl, PR. Brauer and PH. Francis-West - Chapter 11 Limb Dev (bone not well covered in this textbook)

Before we Are Born (5th ed.) Moore and Persaud Ch16,17: p379-397, 399-405
Essentials of Human Embryology Larson Ch11 p207-228

Early Development and Neural Derivatives

Abnormalities

References

Textbooks

The Developing Human: Clinically Oriented Embryology (8th Edition) by Keith L. Moore and T.V.N Persaud - Moore & Persaud Chapter Chapter 10 The Pharyngeal Apparatus pp201 - 240.
Larsen’s Human Embryology by GC. Schoenwolf, SB. Bleyl, PR. Brauer and PH. Francis-West - Chapter 12 Development of the Head, the Neck, the Eyes, and the Ears pp349 - 418.

Online Textbooks

Developmental Biology by Gilbert, Scott F. Sunderland (MA): Sinauer Associates, Inc.; c2000

Molecular Biology of the Cell Alberts, Bruce; Johnson, Alexander; Lewis, Julian; Raff, Martin; Roberts, Keith; Walter, Peter New York and London: Garland Science; c2002 Search Molecular Biology of the Cell Bone Is Continually Remodeled by the Cells Within It Image: Figure 22-52. Deposition of bone matrix by osteoblasts.Image: Figure 22-56. The development of a long bone.

Search

Bookshelf neural crest

Pubmed neural crest

UNSW Embryology Links

Notes: Bone Development | Limb Development | Axial Skeleton Development | Bone Development | Skull | Development Limb | Axial Skeleton| Human Bone | Endochondral Ossification | Skeletal Muscle | Cartilage | Joints

Lectures: ANAT2341 - Embryology 2008 - Lecture 16
Movies: Neural Movies

External Links

Glossary Links

Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link

Course Content 2009

Cite this page: Hill, M.A. (2024, June 3) Embryology 2009 Lecture 13. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/2009_Lecture_13

What Links Here?

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 ===Online Textbooks===
-* '''Developmental Biology''' by Gilbert, Scott F. Sunderland (MA): Sinauer Associates, Inc.; c2000 [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=dbio.section.3109#3133 The Cranial Neural Crest] | [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=dbio.figgrp.3111 Figure 13.1. Regions of the neural crest] | [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=dbio.figgrp.3134 Figure 13.7. Cranial neural crest cell migration in the mammalian head] | [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=dbio.figgrp.3118 Figure 13.2. Neural crest cell migration in the trunk of the chick embryo] | [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=dbio.figgrp.3138 Figure 13.10. Separation of the truncus arteriosus into the pulmonary artery and aorta] | [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=dbio.figgrp.5460 Figure 22.23. Chick embryo rhombomere neural crest cells and their musculoskeletal packets] | [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=dbio.figgrp.3127 Figure 13.4. Segmental restriction of neural crest cells and motor neurons by the ephrin proteins of the sclerotome] |  [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=dbio.figgrp.43 Figure 1.3. Pharyngeal arches] | [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=dbio.table.3135 Table 13.2. Some derivatives of the pharyngeal arches]
+* '''Developmental Biology''' by Gilbert, Scott F. Sunderland (MA): Sinauer Associates, Inc.; c2000
-:Neural Crest Experiments: [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=dbio.figgrp.63 Figure 1.11. Neural crest cell migration Chimera experiment] | [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=dbio.figgrp.3130 Figure 13.5. Pluripotency of trunk neural crest cells]
-* '''Molecular Biology of the Cell''' Alberts, Bruce; Johnson, Alexander; Lewis, Julian; Raff, Martin; Roberts, Keith; Walter, Peter New York and London: Garland Science; c2002 [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mboc4.figgrp.3946 Figure 21-80. The main pathways of neural crest cell migration] [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mboc4.figgrp.3968 Figure 21-91. Diagram of a 2-day chick embryo, showing the origins of the nervous system] | [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?highlight=neural_crest&rid=mboc4.figgrp.3511 Figure 19-23. An example of a more complex mechanism by which cells assemble to form a tissue]
+* '''Molecular Biology of the Cell''' Alberts, Bruce; Johnson, Alexander; Lewis, Julian; Raff, Martin; Roberts, Keith; Walter, Peter New York and London: Garland Science; c2002 [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowTOC&rid=mboc4.TOC&depth=2 Search Molecular Biology of the Cell][http://www.ncbi.nlm.nih.gov:80/books/bv.fcgi?db=Books&rid=mboc4.section.4177#4187 Bone Is Continually Remodeled by the Cells Within It][http://www.ncbi.nlm.nih.gov:80/books/bv.fcgi?db=Books&rid=mboc4.figgrp.4191 Image: Figure 22-52. Deposition of bone matrix by osteoblasts.][http://www.ncbi.nlm.nih.gov:80/books/bv.fcgi?db=Books&rid=mboc4.figgrp.4196 Image: Figure 22-56. The development of a long bone.]
-* '''Neuroscience''' Purves, Dale; Augustine, George J.; Fitzpatrick, David; Katz, Lawrence C.; LaMantia, Anthony-Samuel; McNamara, James O.; Williams, S. Mark. Sunderland (MA): Sinauer Associates, Inc.; c2001[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=neurosci.figgrp.1449 Figure 22.1. Neurulation in the mammalian embryo] | [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=neurosci.figgrp.1503 Figure 22.12. Cell signaling during the migration of neural crest cells]
-* '''Madame Curie Bioscience Database''' Chapters taken from the Madame Curie Bioscience Database (formerly, Eurekah Bioscience Database) [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=eurekah&part=A53006 Cranial Neural Crest and Development of the Head Skeleton] | [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=eurekah&part=ch2957 Neural Crest Cells and the Community of Plan for Craniofacial Development: Historical Debates and Current Perspectives] | [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=eurekah&part=A63004&rendertype=figure&id=A63009 Figure 1. Diagram of an E10 embryo showing the origins of neural crest cells that colonize the developing gastrointestinal tract]
-* '''Basic Neurochemistry: Molecular, Cellular, and Medical Aspects''' Siegel, George J.; Agranoff, Bernard W.; Albers, R. Wayne; Fisher, Stephen K.; Uhler, Michael D., editors Philadelphia: Lippincott,Williams & Wilkins; c1999[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=bnchm.figgrp.1881 Figure 27-10. Neuropoietic model of neural crest cell lineage] | [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?highlight=neural_crest&rid=bnchm.figgrp.1883 Figure 27-11. Growth factor control of neural crest lineage decisions] | [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?highlight=neural_crest&rid=bnchm.figgrp.1893 Figure 27-15. The Schwann cell lineage]
 ===Search ===

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