Vision - Lens Development: Difference between revisions
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Wnt mediates lens repression by neural crest cells and Transforming growth factor-β<ref>Grocott T, Johnson S, Bailey AP, Streit A. '''Neural crest cells organize the eye via TGF-β and canonical Wnt signalling.''' Nat Commun. 2011 Apr;2:265. [http://www.ncbi.nlm.nih.gov/pubmed/21468017 PMID21468017] | [http://www.nature.com/ncomms/journal/v2/n4/full/ncomms1269.html Nat Commun.]</ref> (open image for full description) | Wnt mediates lens repression by neural crest cells and Transforming growth factor-β<ref>Grocott T, Johnson S, Bailey AP, Streit A. '''Neural crest cells organize the eye via TGF-β and canonical Wnt signalling.''' Nat Commun. 2011 Apr;2:265. [http://www.ncbi.nlm.nih.gov/pubmed/21468017 PMID21468017] | [http://www.nature.com/ncomms/journal/v2/n4/full/ncomms1269.html Nat Commun.]</ref> (open image for full description) | ||
:'''Links:''' [[Vision_-_Lens_Development|Lens Development]] | [[:File:Eye-neural crest signaling.jpg|Lens repression by neural crest cells]] | [[:File:Lens-neural crest signaling 01.jpg|Proposed model how NCCs organize the eye]] | [[:File:Lens-neural crest signaling 02.jpg|molecular model to explain TGF-β- and Wnt-mediated lens restriction]] | |||
==References== | ==References== |
Revision as of 14:11, 29 April 2011
Introduction
The lens or crystalline lens or aquula (Latin, aquula = a little stream) has a key role in focussing light (with the cornea) upon the neural retina. The lens embryonic origin is from surface ectoderm of the sensory placodes that form in the head region (More? Week 4 - Placodes). The lens focusses by refracting light as it passes through the biconvex lens, which can be altered in shape (accommodation) by surrounding ciliary muscles. These ciliary muscles are activated (contracted) by parasympathetic innervation from the ciliary ganglion itself innervated by the oculomotor nerve (Cranial Nerve III) (More? Cranial Nerves).
Some Recent Findings
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Development Overview
surface ectoderm -> lens placode -> lens pit -> lens vesicle -> lens fibres -> lens capsule and embryonic/fetal nucleus.
Stage 13
Stage 22
Molecular Signaling
Wnt mediates lens repression by neural crest cells and Transforming growth factor-β[3] (open image for full description)
- Links: Lens Development | Lens repression by neural crest cells | Proposed model how NCCs organize the eye | molecular model to explain TGF-β- and Wnt-mediated lens restriction
References
- ↑ <pubmed>20171212</pubmed>
- ↑ <pubmed>20105280</pubmed>
- ↑ Grocott T, Johnson S, Bailey AP, Streit A. Neural crest cells organize the eye via TGF-β and canonical Wnt signalling. Nat Commun. 2011 Apr;2:265. PMID21468017 | Nat Commun.
Glossary Links
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Cite this page: Hill, M.A. (2024, June 16) Embryology Vision - Lens Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Vision_-_Lens_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G