Notochord: Difference between revisions
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Thought to have at least 2 early roles in development and later roles in patterning surrounding tissues. 1. Mechanical, influencing the folding of the early [[E#embryo|embryo]]; 2. Morphogenic, secreting sonic hedgehog a protein which regulates the development of surrounding tissues (neural plate, somites, [[E#endoderm|endoderm]] and other organs). | Thought to have at least 2 early roles in development and later roles in patterning surrounding tissues. 1. Mechanical, influencing the folding of the early [[E#embryo|embryo]]; 2. Morphogenic, secreting sonic hedgehog a protein which regulates the development of surrounding tissues (neural plate, somites, [[E#endoderm|endoderm]] and other organs). | ||
In humans, the notochord forms in week 3, is eventually lost | In humans, the notochord forms in week 3, is eventually lost from vertebral regions and contributes to the nucleus pulposus of the intervertebral disc during the formation of the vertebral column. | ||
:'''Links:''' [[Notochord]] | [[Development Animation - Notochord]] | [[Musculoskeletal System Development|Musculoskeletal]] | [[Neural_System_Development|Neural]] | [[Sonic hedgehog]] | :'''Links:''' [[Notochord]] | [[Development Animation - Notochord]] | [[Musculoskeletal System Development|Musculoskeletal]] | [[Neural_System_Development|Neural]] | [[Sonic hedgehog]] |
Revision as of 15:07, 2 August 2010
Introduction
The notochord (axial mesoderm) is an early forming midline structure in the trilaminar embryo mesoderm layer initially ventral to the ectoderm, then neural plate and finally neural tube. This is a transient embryo anatomy structure, not existing in the adult, required for patterning the surrounding tissues. The patterning signal secreted by notochord cells is sonic hedgehog (shh). This secreted protein binds to receptors on target cells activating a signaling pathway involved in that tissues differentiation and development. This response appears to be concentration dependent, that is the closer to the notochord the higher the shh concentration.
Thought to have at least 2 early roles in development and later roles in patterning surrounding tissues. 1. Mechanical, influencing the folding of the early embryo; 2. Morphogenic, secreting sonic hedgehog a protein which regulates the development of surrounding tissues (neural plate, somites, endoderm and other organs).
In humans, the notochord forms in week 3, is eventually lost from vertebral regions and contributes to the nucleus pulposus of the intervertebral disc during the formation of the vertebral column.
Some Recent Findings
References
Reviews
<pubmed>16314867</pubmed> <pubmed>19206138</pubmed>
Articles
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Search NLM Online Textbooks: "Notochord" : Developmental Biology | The Cell- A molecular Approach | Molecular Biology of the Cell | Endocrinology
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Cite this page: Hill, M.A. (2024, June 18) Embryology Notochord. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Notochord
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G