Notochord: Difference between revisions

Revision as of 15:06, 2 August 2010

Introduction

The notochord (axial mesoderm) is an early forming midline structure in the trilaminar embryo mesoderm layer initially ventral to the ectoderm, then neural plate and finally neural tube. This is a transient embryo anatomy structure, not existing in the adult, required for patterning the surrounding tissues. The patterning signal secreted by notochord cells is sonic hedgehog (shh). This secreted protein binds to receptors on target cells activating a signaling pathway involved in that tissues differentiation and development. This response appears to be concentration dependent, that is the closer to the notochord the higher the shh concentration.

Thought to have at least 2 early roles in development and later roles in patterning surrounding tissues. 1. Mechanical, influencing the folding of the early embryo; 2. Morphogenic, secreting sonic hedgehog a protein which regulates the development of surrounding tissues (neural plate, somites, endoderm and other organs).

In humans, the notochord forms in week 3, is eventually lost during the formation of the vertebral column and contributes to the nucleus pulposus of the intervertebral disc.

Links: Notochord | Development Animation - Notochord | Musculoskeletal | Neural | Sonic hedgehog

Some Recent Findings

References

Reviews

Articles

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Search NLM Online Textbooks: "Notochord" : Developmental Biology | The Cell- A molecular Approach | Molecular Biology of the Cell | Endocrinology

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Cite this page: Hill, M.A. (2024, June 2) Embryology Notochord. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Notochord

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 ==Introduction==
-(axial mesoderm) The rod of cells lying in the midline of the  [[T#trilaminar embryo|trilaminar embryo]] [[M#mesoderm|mesoderm]] layer ventral to the neural tube. Thought to have at least 2 early roles in development and later roles in patterning surrounding tissues. 1. Mechanical, influencing the folding of the early [[E#embryo|embryo]]; 2. Morphogenic, secreting sonic hedgehog a protein which regulates the development of surrounding tissues (neural plate, somites, [[E#endoderm|endoderm]] and other organs). In humans, the notochord forms in week 3 and is eventually lost during the formation of the vertebral column.
+The notochord (axial mesoderm) is an early forming midline structure in the [[T#trilaminar embryo|trilaminar embryo]] [[M#mesoderm|mesoderm]] layer initially ventral to the ectoderm, then neural plate and finally neural tube. This is a transient embryo anatomy structure, not existing in the adult, required for patterning the surrounding tissues. The patterning signal secreted by notochord cells is sonic hedgehog (shh). This secreted protein binds to receptors on target cells activating a signaling pathway involved in that tissues differentiation and development. This response appears to be concentration dependent, that is the closer to the notochord the higher the shh concentration.
+Thought to have at least 2 early roles in development and later roles in patterning surrounding tissues. 1. Mechanical, influencing the folding of the early [[E#embryo|embryo]]; 2. Morphogenic, secreting sonic hedgehog a protein which regulates the development of surrounding tissues (neural plate, somites, [[E#endoderm|endoderm]] and other organs).
+In humans, the notochord forms in week 3, is eventually lost during the formation of the vertebral column and contributes to the nucleus pulposus of the intervertebral disc.
 :'''Links:''' [[Notochord]] | [[Development Animation - Notochord]] | [[Musculoskeletal System Development|Musculoskeletal]] | [[Neural_System_Development|Neural]] | [[Sonic hedgehog]]
+===Some Recent Findings===
 == References ==