Talk:Human Abnormal Development: Difference between revisions

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Lead effects PMID 20562053

2012

Prevalence of birth defects in korean livebirths, 2005-2006

J Korean Med Sci. 2012 Oct;27(10):1233-40. doi: 10.3346/jkms.2012.27.10.1233. Epub 2012 Oct 2.

Kim MA, Yee NH, Choi JS, Choi JY, Seo K. Source Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Abstract

We investigated the livebirths prevalence and occurrence pattern of birth defects in Korea. After the survey on birth defects was done in 2,348 medical institutions around the nation, the birth defect prevalence of livebirths in 2005-2006 was calculated. This study was based on the medical insurance claims database of the National Health Insurance Corporation. The number of livebirths in Korea was 883,184 from 2005-2006, and 25,335 cases of birth defects were notified to our study, equivalent to a prevalence of 286.9 per 10,000 livebirths. Anomalies of the circulatory system were the most common defects, accounting for 43.4% of birth defects with a prevalence of 124.5 per 10,000 livebirths. It was followed by the musculoskeletal system anomalies, the digestive system anomalies, and the urinary system anomalies. The five major birth defects based on the ranking of prevalence were atrial septal defect, ventricular septal defect, hydronephrosis, patent ductus arteriosus, and cleft lip/palate. Birth defects in livebirths were associated with a high proportion of low birthweight, prematurity, multiple births and advanced maternal age. The prevalence of birth defects in Korea is similar to or lower than those reported in developed countries. Our study suggests baseline data to explain the current status of birth defects and to establish a registry system of birth defects in Korea.

PMID 23091323

1993

Registries of congenital anomalies: EUROCAT

Environ Health Perspect. 1993 Jul;101 Suppl 2:153-7.

Lechat MF, Dolk H. Source Department of Epidemiology and Preventive Medicine, Catholic University of Louvain, Brussels, Belgium.

Abstract

Congenital anomalies are one of the potential adverse effects of the environment on reproductive health. Registries of congenital anomalies are useful to detect abnormal frequencies, clusters, and trends. Such registries should meet a number of conditions, including an appropriate population denominator, an efficient system for collecting information, standardized diagnostic procedures, postmortem examinations of still-births, and linkage of records. The EUROCAT (European Registration of Congenital Anomalies and Twins) program is a Concerted Action of the Commission of the European Communities initiated in 1979. One of its objectives is the surveillance of congenital anomalies as related to environmental hazards. This surveillance system covers at present 350,000 births per year in 15 countries. A number of problems encountered in the development of EUROCAT and in the course of ongoing activities are reviewed: populations coverage, classification of malformations, coding, definition and coverage of late fetal death, registration of induced abortion, validation of diagnostic information, registration of late diagnosed cases, and maintenance of motivation in data collection. The issue of confidentiality and the need for strict safeguards for the protection of individual privacy are emphasized.

PMID 8243386

Australia - Advisory Committee on Prescription Medicines

The Australian Drug Evaluation Committee (ADEC) was established in 1963 following the thalidomide experience and in 2010 this committee was replaced by the Advisory Committee on Prescription Medicines (ACPM). The new ACPM advises and makes recommendations to the Therapeutic Goods Administration (TGA) on prescription medicines listed on the Australian Register of Therapeutic Goods (ARTG), established under the Therapeutic Goods Act 1989. There were approximately 54,000 products on the Australian Register of Therapeutic Goods as at 23 May 2008.

Advisory Committee on Prescription Medicines

inclusion of a prescription medicine on the Australian Register of Therapeutic Goods (the Register)
changes to an entry of a prescription medicine on the Register
removal or retention of a prescription medicine on the Register

Links: Advisory Committee on Prescription Medicines

Cytomegalovirus infection in pregnancy. http://www.ncbi.nlm.nih.gov/pubmed/20500943

Australian Congenital Anomalies Monitoring System (ACAMS)

USA (2004–2006)

National estimates for 21 selected major birth defects, 2004–2006

CDC Birth Defects - Data & Statistics

Birth Defects	Cases per Births	Estimated Annual Number of Cases
Anencephaly	1 in 4,859	859
Spina bifida without anencephaly	1 in 2,858	1,460
Encephalocele	1 in 12,235	341
Anophthalmia/microphthalmia	1 in 5,349	780
Common truncus	1 in 13,876	301
Transposition of great arteries	1 in 3,333	1,252
Tetralogy of Fallot	1 in 2,518	1,657
Atrioventricular septal defect	1 in 2,122	1,966
Hypoplastic left heart syndrome	1 in 4,344	960
Cleft palate without cleft lip	1 in 1,574	2,651
Cleft lip with and without cleft palate	1 in 940	4,437
Esophageal atresia/tracheoesophageal fistula	1 in 4,608	905
Rectal and large intestinal atresia/stenosis	1 in 2,138	1,952
Reduction deformity, upper limbs	1 in 2,869	1,454
Reduction deformity, lower limbs	1 in 5,949	701
Gastroschisis	1 in 2,229	1,871
Omphalocele	1 in 5,386	775
Diaphragmatic hernia	1 in 3,836	1,088
Trisomy 13	1 in 7,906	528
Trisomy 21 (Down syndrome)	1 in 691	6,037
Trisomy 18	1 in 3,762	1,109

Birth Defects	Cases per Births (1 in ...)	Estimated Annual Number of Cases
Anencephaly	4,859	859
Spina bifida without anencephaly	2,858	1,460
Encephalocele	12,235	341
Anophthalmia/microphthalmia	5,349	780
Common truncus	13,876	301
Transposition of great arteries	3,333	1,252
Tetralogy of Fallot	2,518	1,657
Atrioventricular septal defect	2,122	1,966
Hypoplastic left heart syndrome	4,344	960
Cleft palate without cleft lip	1,574	2,651
Cleft lip with and without cleft palate	940	4,437
Esophageal atresia/tracheoesophageal fistula	4,608	905
Rectal and large intestinal atresia/stenosis	2,138	1,952
Reduction deformity, upper limbs	2,869	1,454
Reduction deformity, lower limbs	5,949	701
Gastroschisis	2,229	1,871
Omphalocele	5,386	775
Diaphragmatic hernia	3,836	1,088
Trisomy 13	7,906	528
Trisomy 21 (Down syndrome)	691	6,037
Trisomy 18	3,762	1,109

Original Page Links

Abnormal Development

Abnormalities by System

Abnormalities Links: Introduction | Genetic | Environmental | Unknown | Teratogens

The links below take you to the related systems abnormality page in each section of Notes. Additional pages relating to specific abnormalities will also be linked from these introductory pages.

Birth defects in Victoria

http://www.health.vic.gov.au/ccopmm/statistics/bdv.htm

2007 data

Fetal lead exposure and infant mental development index. Ronchetti R. Environ Health Perspect. 2007 Apr;115(4):A186; author reply A186-7. No abstract available. PMID: 17450196 | PMC1852654 This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose

Hu H, Téllez-Rojo MM, Bellinger D, Smith D, Ettinger AS, Lamadrid-Figueroa H, et al. Fetal lead exposure at each stage of pregnancy as a predictor of infant mental development. Environ Health Perspect. 2006;114:1730–1735. doi: 10.1289/ehp.9067. [Online 19 July 2006]

Western Australia

A retrospective population-based study of childhood hospital admissions with record linkage to a birth defects registry

http://www.biomedcentral.com/1471-2431/9/32

@@ Line 15: / Line 15: @@
 PMID 23091323
+==1993==
+===Registries of congenital anomalies: EUROCAT===
+Environ Health Perspect. 1993 Jul;101 Suppl 2:153-7.
+Lechat MF, Dolk H.
+Source
+Department of Epidemiology and Preventive Medicine, Catholic University of Louvain, Brussels, Belgium.
+Abstract
+Congenital anomalies are one of the potential adverse effects of the environment on reproductive health. Registries of congenital anomalies are useful to detect abnormal frequencies, clusters, and trends. Such registries should meet a number of conditions, including an appropriate population denominator, an efficient system for collecting information, standardized diagnostic procedures, postmortem examinations of still-births, and linkage of records. The EUROCAT (European Registration of Congenital Anomalies and Twins) program is a Concerted Action of the Commission of the European Communities initiated in 1979. One of its objectives is the surveillance of congenital anomalies as related to environmental hazards. This surveillance system covers at present 350,000 births per year in 15 countries. A number of problems encountered in the development of EUROCAT and in the course of ongoing activities are reviewed: populations coverage, classification of malformations, coding, definition and coverage of late fetal death, registration of induced abortion, validation of diagnostic information, registration of late diagnosed cases, and maintenance of motivation in data collection. The issue of confidentiality and the need for strict safeguards for the protection of individual privacy are emphasized.
+PMID 8243386
 ==Australia - Advisory Committee on Prescription Medicines==