Developmental Mechanism - Mesenchymal Epithelial Transition
|Embryology - 23 May 2019 Expand to Translate|
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In mesenchymal epithelial transition, mesenchymal cells form an embryonic connective tissue with a disorganised cellular organisation can undergo transition to an epithelial organisation (organised cellular layer) as a developmental process and are said to have undergone a Mesenchymal to Epithelial Transition (MET). This morphological change appears to be the opposite process to that seen in epithelial mesenchymal transition.
Mesenchymal cells, connective tissue-like, that have undergone this process may at a later time and under specific signaling can undergo the opposite process, mesenchyme to epithelia. In development, this process can be repeated several times during tissue differentiation.
Some Recent Findings
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<pubmed limit=5> Mesenchymal Epithelial Transition</pubmed>
The alternate process involves the conversion of the embryonic connective tissue organization (mesenchyme) to an epithelial organization (epithelium) that can occur during developmental processes.
This process can be seen occurring during early somitogenesis.
|During early somite formation (somitogenesis) the mesenchymal paraxial mesoderm undergoes a MET to form the initial segment of the somite "ball". This ball of mesoderm has an epithelial outer layer and a core of mesenchyme. The early somite also contains a space, the somitoceol, that is lost as the mesoderm proliferates to form a solid ball.
The somite epithelial layer then breaks down as the somite disperses to form the sclerotome and dermomyotome. The dermomyotome initially remains as an epithelial layer, that also is lost as the dermatome and myotome proliferate and migrate.
(Factor page link)
|Renal Development||Expression Location|
|Wnt9b||Wingless-type MMTV integration site family, Member 9B||renewal and differentiation of nephron progenitors and normal ureteric bud branching, mesenchymal-to-epithelial transition||uteric bud stalk epithelial cells|
- Cousins FL, Murray A, Esnal A, Gibson DA, Critchley HO & Saunders PT. (2014). Evidence from a mouse model that epithelial cell migration and mesenchymal-epithelial transition contribute to rapid restoration of uterine tissue integrity during menstruation. PLoS ONE , 9, e86378. PMID: 24466063 DOI. Cite error: Invalid
<ref>tag; name "PMID24466063" defined multiple times with different content
Search Pubmed: Epithelial Mesenchymal Transition
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Cite this page: Hill, M.A. (2019, May 23) Embryology Developmental Mechanism - Mesenchymal Epithelial Transition. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Mechanism_-_Mesenchymal_Epithelial_Transition
- © Dr Mark Hill 2019, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G