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News - Thalidomide Molecular Mechanism shown in Zebrafish

PMID 27294876 | Nat Med.

Thalidomide (and derivatives lenalidomide and pomalidomide) are treatments for hematologic malignancies, multiple myeloma (MM) and del(5q) myelodysplastic syndrome (MDS). Cereblon (CRBN) is the primary target for both the anticancer and teratogenic effects, and it promotes the maturation of CD147 (also known as Basigin) a member of the immunoglobulin superfamily).

Zebrafish knockdown of CD147 was shown to match the teratogenic effects of thalidomide exposure.

Links: Abnormal Development - Thalidomide | Zebrafish Development

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 PMID 27294876 | [http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.4128.html Nat Med.]
-Thalidomide (and derivatives lenalidomide and pomalidomide) are treatments for hematologic malignancies, multiple myeloma (MM) and del(5q) myelodysplastic syndrome (MDS).  Cereblon (CRBN) is the primary target for both the anticancer and teratogenic effects, and it promotes the maturation of the CD147 ( [http://www.omim.org/entry/109480 OMIM - Basigin], BSG;  a member of the immunoglobulin superfamily).
+Thalidomide (and derivatives lenalidomide and pomalidomide) are treatments for hematologic malignancies, multiple myeloma (MM) and del(5q) myelodysplastic syndrome (MDS).  Cereblon (CRBN) is the primary target for both the anticancer and teratogenic effects, and it promotes the maturation of CD147 ([[Abnormal Development - Thalidomide#CD147 (Basigin)|also known as Basigin]]) a member of the immunoglobulin superfamily).
 Zebrafish knockdown of CD147 was shown to match the teratogenic effects of thalidomide exposure.