Template:Blastocyst Hippo table
From Embryology
| Mouse Blastocyst (32 cell stage) Fate | |||
|---|---|---|---|
| phosphorylation of angiomotin (Amot) at adherens junctions | cell polarization sequesters Amot from basolateral adherens junctions | ||
| active Hippo signaling | inactive Hippo signaling | ||
| inner cells | outer cells | ||
| inner cell mass (ICM) fate |
trophectoderm (TE) fate | ||
| Notch inactive | Notch active | Hippo[1](TEAD4) and Notch[2](Cdx2) together appear regulate early blastocyst fate development. | |
- ↑ Sasaki H. (2015). Position- and polarity-dependent Hippo signaling regulates cell fates in preimplantation mouse embryos. Semin. Cell Dev. Biol. , 47-48, 80-7. PMID: 25986053 DOI.
- ↑ Rayon T, Menchero S, Nieto A, Xenopoulos P, Crespo M, Cockburn K, Cañon S, Sasaki H, Hadjantonakis AK, de la Pompa JL, Rossant J & Manzanares M. (2014). Notch and hippo converge on Cdx2 to specify the trophectoderm lineage in the mouse blastocyst. Dev. Cell , 30, 410-22. PMID: 25127056 DOI.
