Template:Blastocyst Hippo table: Difference between revisions
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! Mouse | ! Mouse Blastocyst (32 cell stage) Fate | ||
|-bgcolor="CEDFF2" | |-bgcolor="CEDFF2" | ||
| width=400px|phosphorylation of angiomotin (Amot) at adherens junctions | | width=400px|phosphorylation of angiomotin (Amot) at adherens junctions | ||
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| trophectoderm (TE) fate<br> | | trophectoderm (TE) fate<br> | ||
|- | |- | ||
| colspan=2| | | Notch inactive | ||
Notch | | Notch active | ||
| colspan=2|[[Developmental Signals - Hippo|Hippo]]{{#pmid:25986053|PMID25986053}}(TEAD4) and [[Developmental Signals - Notch|Notch]]{{#pmid:25127056|PMID25127056}}(Cdx2) together appear regulate early blastocyst fate development. | |||
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Revision as of 10:22, 21 March 2018
| Mouse Blastocyst (32 cell stage) Fate | |||
|---|---|---|---|
| phosphorylation of angiomotin (Amot) at adherens junctions | cell polarization sequesters Amot from basolateral adherens junctions | ||
| active Hippo signaling | inactive Hippo signaling | ||
| inner cells | outer cells | ||
| inner cell mass (ICM) fate |
trophectoderm (TE) fate | ||
| Notch inactive | Notch active | Hippo[1](TEAD4) and Notch[2](Cdx2) together appear regulate early blastocyst fate development. | |
- ↑ Sasaki H. (2015). Position- and polarity-dependent Hippo signaling regulates cell fates in preimplantation mouse embryos. Semin. Cell Dev. Biol. , 47-48, 80-7. PMID: 25986053 DOI.
- ↑ Rayon T, Menchero S, Nieto A, Xenopoulos P, Crespo M, Cockburn K, Cañon S, Sasaki H, Hadjantonakis AK, de la Pompa JL, Rossant J & Manzanares M. (2014). Notch and hippo converge on Cdx2 to specify the trophectoderm lineage in the mouse blastocyst. Dev. Cell , 30, 410-22. PMID: 25127056 DOI.
