Talk:Salivary Gland Development: Difference between revisions
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==2017== | |||
===Fgf10 and Sox9 are essential for the establishment of distal progenitor cells during mouse salivary gland development=== | |||
Development. 2017 Jun 15;144(12):2294-2305. doi: 10.1242/dev.146019. Epub 2017 May 15. | |||
Chatzeli L1, Gaete M1,2, Tucker AS3. | |||
Abstract | |||
Salivary glands are formed by branching morphogenesis with epithelial progenitors forming a network of ducts and acini (secretory cells). During this process, epithelial progenitors specialise into distal (tips of the gland) and proximal (the stalk region) identities that produce the acini and higher order ducts, respectively. Little is known about the factors that regulate progenitor expansion and specialisation in the different parts of the gland. Here, we show that Sox9 is involved in establishing the identity of the distal compartment before the initiation of branching morphogenesis. Sox9 is expressed throughout the gland at the initiation stage before becoming restricted to the distal epithelium from the bud stage and throughout branching morphogenesis. Deletion of Sox9 in the epithelium results in loss of the distal epithelial progenitors, a reduction in proliferation and a subsequent failure in branching. We demonstrate that Sox9 is positively regulated by mesenchymal Fgf10, a process that requires active Erk signalling. These results provide new insights into the factors required for the expansion of salivary gland epithelial progenitors, which can be useful for organ regeneration therapy. | |||
© 2017. Published by The Company of Biologists Ltd. | |||
KEYWORDS: | |||
Branching morphogenesis; Epithelial progenitors; Fgf signalling; Salivary glands; Sox9 | |||
PMID: 28506998 PMCID: PMC5482990 DOI: 10.1242/dev.146019 | |||
==2012== | ==2012== | ||
Revision as of 09:45, 31 August 2017
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Cite this page: Hill, M.A. (2024, May 20) Embryology Salivary Gland Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Talk:Salivary_Gland_Development |
2017
Fgf10 and Sox9 are essential for the establishment of distal progenitor cells during mouse salivary gland development
Development. 2017 Jun 15;144(12):2294-2305. doi: 10.1242/dev.146019. Epub 2017 May 15.
Chatzeli L1, Gaete M1,2, Tucker AS3.
Abstract
Salivary glands are formed by branching morphogenesis with epithelial progenitors forming a network of ducts and acini (secretory cells). During this process, epithelial progenitors specialise into distal (tips of the gland) and proximal (the stalk region) identities that produce the acini and higher order ducts, respectively. Little is known about the factors that regulate progenitor expansion and specialisation in the different parts of the gland. Here, we show that Sox9 is involved in establishing the identity of the distal compartment before the initiation of branching morphogenesis. Sox9 is expressed throughout the gland at the initiation stage before becoming restricted to the distal epithelium from the bud stage and throughout branching morphogenesis. Deletion of Sox9 in the epithelium results in loss of the distal epithelial progenitors, a reduction in proliferation and a subsequent failure in branching. We demonstrate that Sox9 is positively regulated by mesenchymal Fgf10, a process that requires active Erk signalling. These results provide new insights into the factors required for the expansion of salivary gland epithelial progenitors, which can be useful for organ regeneration therapy. © 2017. Published by The Company of Biologists Ltd.
KEYWORDS: Branching morphogenesis; Epithelial progenitors; Fgf signalling; Salivary glands; Sox9 PMID: 28506998 PMCID: PMC5482990 DOI: 10.1242/dev.146019
2012
Anatomy and histology of rodent and human major salivary glands: -overview of the Japan salivary gland society-sponsored workshop
Acta Histochem Cytochem. 2012 Oct 31;45(5):241-50. doi: 10.1267/ahc.12013. Epub 2012 Sep 22.
Amano O1, Mizobe K, Bando Y, Sakiyama K. Author information
Abstract
MAJOR SALIVARY GLANDS OF BOTH HUMANS AND RODENTS CONSIST OF THREE PAIRS OF MACROSCOPIC GLANDS: parotid, submandibular, and sublingual. These glands secrete serous, mucous or mixed saliva via the proper main excretory ducts connecting the glandular bodies with the oral cavity. A series of discoveries about the salivary ducts in the 17th century by Niels Stensen (1638-1686), Thomas Wharton (1614-1673), and Caspar Bartholin (1655-1738) established the concept of exocrine secretion as well as salivary glands. Recent investigations have revealed the endocrine functions of parotin and a variety of cell growth factors produced by salivary glands.The present review aims to describe macroscopic findings on the major salivary glands of rodents and the microscopic differences between those of humans and rodents, which review should be of interest to those researchers studying salivary glands. KEYWORDS: human, immunohistochemistry, mouse, rat, salivary glands
PMID 23209333
