Talk:Abnormal Development - Rubella Virus
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Cite this page: Hill, M.A. (2024, April 27) Embryology Abnormal Development - Rubella Virus. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Talk:Abnormal_Development_-_Rubella_Virus |
2010
Three-dimensional structure of Rubella virus factories
Virology. 2010 Sep 30;405(2):579-91. Epub 2010 Jul 23.
Fontana J, López-Iglesias C, Tzeng WP, Frey TK, Fernández JJ, Risco C. Cell Structure Lab, Centro Nacional de Biotecnología, CSIC, Darwin, Madrid, Spain.
Abstract Viral factories are complex structures in the infected cell where viruses compartmentalize their life cycle. Rubella virus (RUBV) assembles factories by recruitment of rough endoplasmic reticulum (RER), mitochondria and Golgi around modified lysosomes known as cytopathic vacuoles or CPVs. These organelles contain active replication complexes that transfer replicated RNA to assembly sites in Golgi membranes. We have studied the structure of RUBV factory in three dimensions by electron tomography and freeze-fracture. CPVs contain stacked membranes, rigid sheets, small vesicles and large vacuoles. These membranes are interconnected and in communication with the endocytic pathway since they incorporate endocytosed BSA-gold. RER and CPVs are coupled through protein bridges and closely apposed membranes. Golgi vesicles attach to the CPVs but no tight contacts with mitochondria were detected. Immunogold labelling confirmed that the mitochondrial protein p32 is an abundant component around and inside CPVs where it could play important roles in factory activities.
Copyright 2010 Elsevier Inc. All rights reserved.
PMID: 20655079
Congenital rubella syndrome and rubella in Vellore, South India
Epidemiol Infect. 2010 Jul 20:1-5. [Epub ahead of print]
Chandy S, Abraham AM, Jana AK, Agarwal I, Kekre A, Korula G, Selvaraj K, Muliyil JP. Department of Clinical Virology, Christian Medical College, Vellore, India.
Abstract
Rubella, a mild, vaccine-preventable disease, can manifest as congenital rubella syndrome (CRS), a devastating disease of the fetus. To emphasize the inadequacy of the existing rubella vaccination programme in India, we evaluated epidemiological evidence of rubella virus activity with data available from a tertiary-care centre. The proportion of suspected CRS cases that were laboratory confirmed increased from 4% in 2000 to 11% in 2008. During the same period, 329 clinically suspected postnatal rubella cases were tested of which 65 (20%) were laboratory confirmed. Of women (n=770) of childbearing age, 12.5% were susceptible to rubella.
PMID: 20642875 http://www.ncbi.nlm.nih.gov/pubmed/20642875
Controlling rubella and preventing congenital rubella syndrome – global progress, 2009
Wkly Epidemiol Rec. 2010 Oct 15;85(42):413-8.
[Article in English, French] [No authors listed]
"In 2000, WHO published its first position paper on rubella vaccine to guide the introduction of rubella-containing vaccines (RCVs) into national childhood immuni- zation schedules.1 As of December 2009, a total of 130 countries have introduced RCVs, a 57% increase from 83 countries in 1996. In addition, goals to eliminate rubella and congenital rubella syndrome (CRS) by 2010 have been established in the WHO Region of the Americas and by 2015 in the the European Region; the Western Pacific Region has established 2015 as a goal for accelerating rubella control and reducing CRS incidence to <10 cases/million live births. In 2009, a total of 121 344 rubella cases was reported from 167 countries, a 82% decrease from 2000 when 670 894 cases were reported from 102 countries. This report summarizes global data on cases of rubella and CRS and the prog- ress that has been made towards introducing and using RCVs worldwide."
PMID: 20949700 http://www.ncbi.nlm.nih.gov/pubmed/20949700
