Talk:Abnormal Development - Rubella Virus

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Cite this page: Hill, M.A. (2024, April 27) Embryology Abnormal Development - Rubella Virus. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Talk:Abnormal_Development_-_Rubella_Virus

2010

Three-dimensional structure of Rubella virus factories

Virology. 2010 Sep 30;405(2):579-91. Epub 2010 Jul 23.

Fontana J, López-Iglesias C, Tzeng WP, Frey TK, Fernández JJ, Risco C. Cell Structure Lab, Centro Nacional de Biotecnología, CSIC, Darwin, Madrid, Spain.

Abstract Viral factories are complex structures in the infected cell where viruses compartmentalize their life cycle. Rubella virus (RUBV) assembles factories by recruitment of rough endoplasmic reticulum (RER), mitochondria and Golgi around modified lysosomes known as cytopathic vacuoles or CPVs. These organelles contain active replication complexes that transfer replicated RNA to assembly sites in Golgi membranes. We have studied the structure of RUBV factory in three dimensions by electron tomography and freeze-fracture. CPVs contain stacked membranes, rigid sheets, small vesicles and large vacuoles. These membranes are interconnected and in communication with the endocytic pathway since they incorporate endocytosed BSA-gold. RER and CPVs are coupled through protein bridges and closely apposed membranes. Golgi vesicles attach to the CPVs but no tight contacts with mitochondria were detected. Immunogold labelling confirmed that the mitochondrial protein p32 is an abundant component around and inside CPVs where it could play important roles in factory activities.

Copyright 2010 Elsevier Inc. All rights reserved.

PMID: 20655079

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