Talk:Abnormal Development - Rubella Virus
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Cite this page: Hill, M.A. (2024, April 27) Embryology Abnormal Development - Rubella Virus. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Talk:Abnormal_Development_-_Rubella_Virus |
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Congenital Rubella Syndrome
<pubmed limit=5>congenital rubella syndrome</pubmed>
Rubella Virus
<pubmed limit=5>Rubella Virus</pubmed>
2015
2013
Rubella and congenital rubella syndrome control and elimination - global progress, 2000-2012
MMWR Morb Mortal Wkly Rep. 2013 Dec 6;62(48):983-6.
Centers for Disease Control and Prevention (CDC).
Abstract
Rubella virus usually causes a mild fever and rash in children and adults. However, infection during pregnancy, especially during the first trimester, can result in miscarriage, stillbirth, or infants with congenital malformations, known as congenital rubella syndrome (CRS). In 2011, the World Health Organization (WHO) updated guidance on the preferred strategy for introduction of rubella-containing vaccine (RCV) into national routine immunization schedules with an initial wide-age-range vaccination campaign that includes children aged 9 months-15 years. WHO also urged all member states to take the opportunity offered by accelerated measles control and elimination activities as a platform to introduce RCVs. The Global Measles and Rubella Strategic Plan (2012-2020) published by the Measles Rubella Initiative partners in 2012 and the Global Vaccine Action Plan endorsed by the World Health Assembly in 2012 include milestones to eliminate rubella and CRS in two WHO regions by 2015, and eliminate rubella in five WHO regions by 2020. This report summarizes the global progress of rubella and CRS control and elimination during 2000-2012. As of December 2012, a total of 132 (68%) WHO member states had introduced RCV, a 33% increase from 99 member states in 2000. A total of 94,030 rubella cases were reported to WHO in 2012 from 174 member states, an 86% decrease from the 670,894 cases reported in 2000 from 102 member states. The WHO Region of the Americas (AMR) and European Region (EUR) have established rubella elimination goals of 2010 and 2015, respectively. AMR has started to document the elimination of measles, rubella, and CRS; in EUR, rubella incidence has decreased significantly, although outbreaks continue to occur.
PMID 24304830
Results of the rubella elimination program in Catalonia (Spain), 2002-2011
Hum Vaccin Immunother. 2013 Jan 8;9(3). [Epub ahead of print]
Barrabeig I, Torner N, Martínez A, Carmona G, Ciruela P, Batalla J, Costa J, Hernández S, Salleras L, Domínguez A, Of Catalonia TR. Source Agency of Public Health; Barcelona, Spain.
Abstract
Rubella is usually a mild disease with nonspecific symptoms, but can cause congenital rubella syndrome (CRS) when infection occurs during pregnancy. The objective of this study was to evaluate the sensitivity and positive predictive value of different data sources used for surveillance purposes in the Rubella Elimination Program of Catalonia between 2002 and 2011. The Urgent Notification to the Statutory Disease Reporting System, the Individualized Disease Reporting System, screening for other viruses included in the Measles Elimination Program, the Microbiological Reporting System and the Minimum Hospital Discharge Data were evaluated. 100 suspected cases of postnatal rubella and 6 suspected cases of CRS were detected. For postnatal rubella, Urgent Notification had the highest sensitivity (32.5%; 95%CI 18.6-49.1), followed by the Microbiological Reporting System (22.5%; 95%CI 10.8-38.5). Virus screening in the Measles Elimination Program had the highest PPV (76.9%; 95%CI 46.1-94.9), followed by the Individualized Statutory Disease Reporting System (57.1%; 95%CI 28.9-82.3). For CRS cases, the Individualized Statutory Reporting System had the highest sensitivity (100%, 95%CI 29.2-100) and the highest PPV (60%; 95%CI 14.7-100). Most confirmed postnatal cases (25 cases, 48.1%) were in the 25-44 y age group followed by the 15-24 y age group (11 cases, 21.2%). The highest values of sensitivity and PPV for the detection of confirmed cases corresponded to activities that were specifically introduced in the measles and rubella elimination programs.
PMID 23299566
2012
2011
2010
Phylogenetic analysis of rubella viruses involved in congenital rubella infections in France between 1995 and 2009
J Clin Microbiol. 2010 Jul;48(7):2530-5. Epub 2010 May 12.
Vauloup-Fellous C, Hübschen JM, Abernathy ES, Icenogle J, Gaidot N, Dubreuil P, Parent-du-Châtelet I, Grangeot-Keros L, Muller CP. Source INSERM U764, Université Paris-Sud, AP-HP, Microbiology Department, Hôpital Antoine Béclère, Clamart, France. christelle.vauloup@abc.aphp.fr
Abstract
Rubella is an acute infectious disease that normally has a mild clinical course. However, infections during pregnancy, especially before week 12 of gestation (WG), can cause severe birth defects known as congenital rubella syndrome (CRS). The aim of this study was to perform genotyping and molecular characterization of rubella viruses involved in congenital infections in France over the past 15 years (1995 to 2009). Amniotic fluid (AF) specimens (n = 80) from pregnant women with congenital rubella infections (CRI) before week 20 of gestation, and a few other samples available from children/newborns with CRS (n = 26), were analyzed. The coding region of the rubella virus E1 gene was amplified directly from clinical specimens by reverse transcriptase PCR, and the resulting DNA fragments were sequenced. Sequences were assigned to genotypes by phylogenetic analysis with rubella virus reference sequences. Sufficient E1 gene sequences were obtained from 56 cases. Phylogenetic analysis of the sequences showed that at least five different genotypes (1E, 1G, 1B, 2B, and 1h) were present in France and were involved in congenital infections, with a strong predominance of genotype 1E (87%). This is one of the very few comprehensive studies of rubella viruses involved in CRI. The results indicated that over the past 15 years, multiple introductions of the dominant genotype E caused most of the CRI cases in France. A few sporadic cases were due to other genotypes (1B, 1G, 1h, 2B).
PMID: 20463161 http://www.ncbi.nlm.nih.gov/pubmed/20463161
http://jcm.asm.org/cgi/content/full/48/7/2530?view=long&pmid=20463161
Congenital rubella syndrome and delayed manifestations
Int J Pediatr Otorhinolaryngol. 2010 Sep;74(9):1067-70. Epub 2010 Jul 8.
Dammeyer J. Source Department of Psychology, University of Copenhagen, Denmark. jesper.dammeyer@psy.ku.dk
Abstract
OBJECTIVE: Several hypotheses of different medical and psychological delayed manifestations among people who have congenital rubella syndrome (CRS) have been discussed. This study tests some of these hypotheses of delayed manifestations.
METHODS: Gathering information about 35 individuals who have CRS and who are congenitally deafblind.
RESULTS: None of the hypotheses could be confirmed when individuals with CRS were compared to a control group of individuals who were congenital deafblind with different aetiology than CRS.
CONCLUSIONS: This study concludes that those health related problems which people with CRS face must primarily be understood in relation to congenital deafblindness and dual sensory and communicative deprivation.
Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
PMID: 20619470 http://www.ncbi.nlm.nih.gov/pubmed/20619470
Three-dimensional structure of Rubella virus factories
Virology. 2010 Sep 30;405(2):579-91. Epub 2010 Jul 23.
Fontana J, López-Iglesias C, Tzeng WP, Frey TK, Fernández JJ, Risco C. Cell Structure Lab, Centro Nacional de Biotecnología, CSIC, Darwin, Madrid, Spain.
Abstract Viral factories are complex structures in the infected cell where viruses compartmentalize their life cycle. Rubella virus (RUBV) assembles factories by recruitment of rough endoplasmic reticulum (RER), mitochondria and Golgi around modified lysosomes known as cytopathic vacuoles or CPVs. These organelles contain active replication complexes that transfer replicated RNA to assembly sites in Golgi membranes. We have studied the structure of RUBV factory in three dimensions by electron tomography and freeze-fracture. CPVs contain stacked membranes, rigid sheets, small vesicles and large vacuoles. These membranes are interconnected and in communication with the endocytic pathway since they incorporate endocytosed BSA-gold. RER and CPVs are coupled through protein bridges and closely apposed membranes. Golgi vesicles attach to the CPVs but no tight contacts with mitochondria were detected. Immunogold labelling confirmed that the mitochondrial protein p32 is an abundant component around and inside CPVs where it could play important roles in factory activities.
Copyright 2010 Elsevier Inc. All rights reserved.
PMID: 20655079
Congenital rubella syndrome and rubella in Vellore, South India
Epidemiol Infect. 2010 Jul 20:1-5. [Epub ahead of print]
Chandy S, Abraham AM, Jana AK, Agarwal I, Kekre A, Korula G, Selvaraj K, Muliyil JP. Department of Clinical Virology, Christian Medical College, Vellore, India.
Abstract
Rubella, a mild, vaccine-preventable disease, can manifest as congenital rubella syndrome (CRS), a devastating disease of the fetus. To emphasize the inadequacy of the existing rubella vaccination programme in India, we evaluated epidemiological evidence of rubella virus activity with data available from a tertiary-care centre. The proportion of suspected CRS cases that were laboratory confirmed increased from 4% in 2000 to 11% in 2008. During the same period, 329 clinically suspected postnatal rubella cases were tested of which 65 (20%) were laboratory confirmed. Of women (n=770) of childbearing age, 12.5% were susceptible to rubella.
PMID: 20642875 http://www.ncbi.nlm.nih.gov/pubmed/20642875
Controlling rubella and preventing congenital rubella syndrome – global progress, 2009
Wkly Epidemiol Rec. 2010 Oct 15;85(42):413-8.
[Article in English, French] [No authors listed]
"In 2000, WHO published its first position paper on rubella vaccine to guide the introduction of rubella-containing vaccines (RCVs) into national childhood immuni- zation schedules.1 As of December 2009, a total of 130 countries have introduced RCVs, a 57% increase from 83 countries in 1996. In addition, goals to eliminate rubella and congenital rubella syndrome (CRS) by 2010 have been established in the WHO Region of the Americas and by 2015 in the the European Region; the Western Pacific Region has established 2015 as a goal for accelerating rubella control and reducing CRS incidence to <10 cases/million live births. In 2009, a total of 121 344 rubella cases was reported from 167 countries, a 82% decrease from 2000 when 670 894 cases were reported from 102 countries. This report summarizes global data on cases of rubella and CRS and the prog- ress that has been made towards introducing and using RCVs worldwide."
PMID: 20949700 http://www.ncbi.nlm.nih.gov/pubmed/20949700
http://www.who.int/wer/2010/wer8542.pdf
2008
Vaccine preventable diseases and vaccination coverage in Aboriginal and Torres Strait Islander people, Australia 2003 to 2006
Commun Dis Intell. 2008 Jun;32 Suppl:S2-67.
Menzies R, Turnour C, Chiu C, McIntyre P. Source National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, Australia.
Abstract
This, the second report on vaccine preventable diseases and vaccination coverage in Aboriginal and Torres Strait Islander people, brings together the relevant sources of routinely collected data on vaccine preventable diseases--notifications, hospitalisations, deaths, and childhood and adult vaccination coverage. As a result of continued improvements in the collection of data on Indigenous status, this second report is considerably more comprehensive, with data available from more jurisdictions, and more detailed presentation, including time trends and vaccination coverage by jurisdiction. Vaccination coverage data provide evidence of successful program delivery and highlight some areas for improvement. For universally funded vaccines in children, coverage is similar in Indigenous and non-Indigenous children by 24 months of age. However, delayed vaccination is more common in Indigenous children, with 6%-8% fewer children fully vaccinated at 12 months of age. More timely vaccination, particularly within the first six months of life, is particularly important in reducing the disproportionate burdens of disease due to pertussis and Haemophilus influenzae type b (Hib). For vaccination programs targeted specifically at Aboriginal and Torres Strait Islander children and adults, coverage is substantially lower than for those programs targeted at all Australians. This is true for hepatitis A and polysaccharide pneumococcal vaccine for children, and influenza and polysaccharide pneumococcal vaccine for adults. Targeted vaccination programs present a particular challenge for health services in urban areas. Nevertheless, the impact of vaccination programs in preventing disease and reducing the disparity of disease burden between Aboriginal and Torres Strait Islander and non-Indigenous people has been substantial. This is evident in data on notifications, hospitalisations and deaths. Diseases which, in the past, have had devastating and often disproportionately high impact on Indigenous people, such as diphtheria, measles, poliomyelitis, smallpox and tetanus, are now completely or almost completely absent from Australia. Hepatitis B infection, another disease responsible for high levels of infection and substantial serious illness and death in the pre-vaccine era, is also now well controlled in age groups eligible for vaccination. Although invasive Hib disease is now rare in Australia since the introduction of vaccination in 1993, higher rates of disease persist in Aboriginal and Torres Strait Islander children. More research is needed into the contribution of environmental factors, delayed vaccination and vaccine failure to this continued disparity. Hepatitis A has disproportionately affected Aboriginal and Torres Strait Islander children in the past. Vaccination programs in north Queensland and in various other countries have been very successful in reducing the burden of hepatitis A. It is too early to assess the impact of the vaccination program for Aboriginal and Torres Strait Islander children that commenced in regions outside north Queensland in November 2005. For some other diseases the situation is more complicated. The substantial impact of the national meningococcal C vaccination program since 2003 is evident in this report, although the higher proportion of non-vaccine preventable serotype B disease in Aboriginal and Torres Strait Islander people underlines the need for a new vaccine to cover this serotype. Pneumonia remains the most important communicable disease contributor to premature mortality in Aboriginal and Torres Strait Islander people of all ages. In young Indigenous adults, the eightfold higher rate of hospitalisation compared with their non-Indigenous peers, and the 11-fold higher rate of invasive pneumococcal disease, suggest the need for more widespread use of influenza and pneumococcal vaccines in this age group. Current coverage for Indigenous 15-49 year olds, where influenza and pneumococcal vaccines are funded only for those with risk factors, is low even though some 70% of this age group have one or more risk factors. Overall, the data presented in this report provide powerful evidence for the impact of vaccines in reducing disease in Aboriginal and Torres Strait Islander people, and also point to areas for further improvement. Immunisation programs are an example of how preventive health programs in general can be enhanced to close the gap in morbidity and mortality between Indigenous and non-Indigenous Australians.
PMID: 18711998 http://www.ncbi.nlm.nih.gov/pubmed/18711998
2007
Rubella
Semin Fetal Neonatal Med. 2007 Jun;12(3):182-92. Epub 2007 Mar 2.
Best JM. Source King's College London School of Medicine, Department of Infection, St Thomas' Hospital, London SE1 7EH, UK. jenny.best@kcl.ac.uk Abstract Rubella is associated with an 80% risk of congenital abnormalities if acquired in the first 12 weeks of pregnancy. Reinfection in early pregnancy presents a much smaller risk. Prenatal diagnosis may be useful to assess the risk to the fetus. Congenital rubella is a progressive disease and some abnormalities will not be present at birth. Rubella and congenital rubella are usually diagnosed by detection of rubella-specific IgM; it may be difficult to confirm a diagnosis of congenital rubella in children over 3 months of age. Rubella vaccines are usually combined with measles and mumps vaccines. Their use has enabled some industrialised countries to eliminate rubella and congenital rubella. Countries should ensure that susceptible women of child-bearing age and health care workers are offered a rubella-containing vaccine. Rubella vaccine is contraindicated during pregnancy, but if a pregnant woman is inadvertently vaccinated it is not an indication for termination or prenatal diagnosis.
PMID: 17337363 http://www.ncbi.nlm.nih.gov/pubmed/17337363
http://www.sciencedirect.com/science/article/pii/S1744165X07000182
Prevalence of prelingual deafness in Italy
Acta Otorhinolaryngol Ital. 2007 Feb;27(1):17-21.
Bubbico L, Rosano A, Spagnolo A. Source Department of Biomedical Sciences, Italian Institute of Social Medicine, Rome, Italy. l.bubbico@iims.it
Abstract
Neonatal hearing loss is the most frequent sensorial congenital defect in newborns. No data are available on worldwide prevalence of congenital deafness. World Health Organization (WHO) data indicate 1-4 cases per 1000 individuals, with a considerable increase in developing countries. A prevalence exceeding 1 per 1000 however, indicates a serious public health problem calling for urgent attention. Aim of the study was the evaluate the prevalence of prelingual deafness in the Italian population and determine the socio-demographic characteristics of the condition. Data were provided by the National Institute of Social Insurance (INPS) and the Italian Central Statistics Institute (ISTAT) and were collected in 18 out of the 20 Italian regions (98.2% of total population). All subjects recognized as deaf-mute by a special medical committee were included. According to law No. 509/1988, they had to present a mean bilateral sensorineural-hearing impairment, detected in neonatal age, which caused the damage in speech development and equal to 60 dB or more for 500-, 1000- and 2000-Hz frequency tones in the better ear. Prevalence rates were calculated according to region and age bracket using updated population data from census 2001. Statistical analyses were performed using the SPSS statistical software package. A total of 40,887 cases of prelingual profound sensorineural hearing loss > or =60 dB were detected in Italy in 2003, for a total prevalence rate of 0.72 per 1000. The hearing impairment prevalence differs according to sex. The overall prevalence is 0.78 per 1000 for males and 0.69 per 1000 for females (p < 0.001). The hearing impairment prevalence differs according to region of residence (p < 0.001). The geographic distribution of prelingual deafness was found to be: North 15,644 cases (0.63 per 1000), Central Italy 7111 cases (0.64 per 1000), South and Islands 18,132 (0.87 per 1000). The prelingual hearing loss is highly prevalent in South Italy (Basilicata, Calabria and Sicily). For the southern regions of Italy, the rate observed in the 50-64 and >64 age groups reached 1.27 and 1.15, respectively. This phenomenon may have been due, in part, to the epidemic incidence of maternal rubella which occurred in the 40's and 50's (in Italy, the rubella vaccination was only recommended starting from 1972), and, in part, to the habit of contracting consanguineous marriages. Data from the Vatican Archives on 520,492 consanguineous marriages, for which dispensation was requested in the period 1911-1964, indicate that in the years 1935-1939, in small villages in South Italy (Basilicata, Calabria, Sicily) consanguineous marriages accounted for over 40% of marriages.
PMID: 17601206 http://www.ncbi.nlm.nih.gov/pubmed/17601206
2006
The history of rubella and rubella vaccination leading to elimination
Clin Infect Dis. 2006 Nov 1;43 Suppl 3:S164-8.
Plotkin SA. Source Department of Pediatrics, University of Pennsylvania, Philadelphia, PA, USA. Stanley.Plotkin@Sanofipasteur.com
Abstract
Congenital rubella syndrome (CRS) was discovered in the 1940s, rubella virus was isolated in the early 1960s, and rubella vaccines became available by the end of the same decade. Systematic vaccination against rubella, usually in combination with measles, has eliminated both the congenital and acquired infection from some developed countries, most recently the United States, as is confirmed by the articles in this supplement. The present article summarizes the clinical syndrome of CRS, the process by which the vaccine was developed, and the history leading up to elimination, as well as the possible extension of elimination on a wider scale.
PMID 16998777
1988
Maternal rubella and the congenital rubella syndrome
Clin Perinatol. 1988 Jun;15(2):247-57.
Freij BJ, South MA, Sever JL. Source Division of Infectious Diseases, Georgetown University School of Medicine, Washington, D.C.
Abstract
The major goal of rubella immunization is the prevention of the congenital rubella syndrome. As many as 20 per cent of women in the reproductive age group in the United States continue to be susceptible to rubella despite the immunization programs currently in place. Intensified efforts are therefore needed to identify persons at risk for infection and to vaccinate them. Women who develop a rubella-like illness during pregnancy should have the diagnosis confirmed serologically because a diagnosis based on clinical criteria alone is unreliable and because of the serious implications of gestational rubella infection. The rubella virus can infect the fetus at any stage of pregnancy, but defects are rarely noted when this occurs after the 16th week of gestation. The most common abnormalities in the congenital rubella syndrome are hearing loss, mental retardation, cardiac malformations, and eye defects. Diabetes mellitus, thyroid disease, glaucoma, and other delayed manifestations of congenital rubella syndrome are common, thereby necessitating long-term followup of these patients. The detection of rubella-specific IgM antibodies in fetal blood is helpful in establishing the diagnosis prenatally and can aid in the management of pregnancies complicated by this infection. Susceptible women identified through screening during pregnancy should be immunized in the immediate postpartum or postabortion period. Although the live, attenuated rubella vaccine is contraindicated during pregnancy, pregnant women who are inadvertently immunized are not candidates for pregnancy termination because no defects consistent with congenital rubella have been reported to date in the offspring of other similarly vaccinated women.
PMID: 3288422 http://www.ncbi.nlm.nih.gov/pubmed/3288422
Norman Gregg (1892–1966)
Causes of birth defects: lessons from history. Lancaster PA. Congenit Anom (Kyoto). 2011 Mar;51(1):2-5. doi: 10.1111/j.1741-4520.2010.00311.x. Review.
PMID: 21158952
Perinatal lessons from the past: Sir Norman Gregg, ChM, MC, of Sydney (1892-1966) and rubella embryopathy. Dunn PM. Arch Dis Child Fetal Neonatal Ed. 2007 Nov;92(6):F513-4.
PMID: 17951553
http://fn.bmj.com/content/92/6/F513.long
Gregg's congenital rubella patients 60 years later.
Forrest JM, Turnbull FM, Sholler GF, Hawker RE, Martin FJ, Doran TT, Burgess MA.
Med J Aust. 2002 Dec 2-16;177(11-12):664-7.
PMID: 12463994
Congenital cataract following German measles in the mother. Abstracts from the publications of the late Sir Norman McAlister Gregg. Hertzberg R. Aust N Z J Ophthalmol. 1985 Aug;13(3):303-9.
PMID: 3907670
The history and medical consequences of rubella. Cooper LZ. Rev Infect Dis. 1985 Mar-Apr;7 Suppl 1:S2-10.
PMID: 3890105
Norman McAlister Gregg. Med J Aust. 1966 Dec 10;2(24):1166-9. No abstract available.
PMID: 5334682
Related Links
HSTAT Archive Collection [Internet]. Bethesda (MD): National Library of Medicine (US); 1977-2002. (This publication is provided for historical reference only and the information may be out of date or incorrect.) Rubella
