Talk:Abnormal Development - Herbal Drugs
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Cite this page: Hill, M.A. (2024, May 6) Embryology Abnormal Development - Herbal Drugs. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Talk:Abnormal_Development_-_Herbal_Drugs |
2019
Li L, Yin Tang L, Liang B, Wang R, Sun Q, Bik San Lau C, Chung Leung P, Fritsche E, Liebsch M, Seiler Wulczyn AEM, Spielmann H & Wang CC. (2019). Evaluation of in vitro embryotoxicity tests for Chinese herbal medicines. Reprod. Toxicol. , 89, 45-53. PMID: 31228572 DOI.
Evaluation of in Vitro Embryotoxicity Tests for Chinese Herbal Medicines
Chinese herbal medicines (CHMs) have been widely used during pregnancy, but feto-embryo safety tests are lacking. Here we evaluated in vitro embryotoxicity tests (IVTs) as alternative methods in assessing developmental toxicity of CHMs. Ten CHMs were selected and classified as strongly, weakly and non-embryotoxic. Three well validated IVTs and prediction models (PMs), including embryonic stem cell test (EST), micromass (MM) and whole embryo culture (WEC), were compared. All strongly embryotoxic CHMs were predicted by MM and WEC PM2. While all weakly embryotoxic CHMs were predicted by MM and WEC PM1. All non-embryotoxic CHMs were classified by EST, MM, but over-classified as weakly embryotoxic by WEC PM1. Overall predictivity, precision and accuracy of WEC determined by PM2 were better than EST and MM tests. Compared with validated chemicals, performance of IVTs for CHMs was comparable. So IVTs are adequate to identify and exclude embryotoxic potential of CHMs in this training set.
2018
Maternal and developmental toxicity of the hallucinogenic plant-based beverage ayahuasca in rats
Reprod Toxicol. 2018 Mar 6. pii: S0890-6238(17)30703-7. doi: 10.1016/j.reprotox.2018.03.002. [Epub ahead of print]
da Motta LG1, de Morais JA2, Tavares ACAM1, Vianna LMS3, Mortari MR4, Amorim RFB3, Carvalho RR5, Paumgartten FJR5, Pic-Taylor A2, Caldas ED6.
Abstract
Rats were treated orally with ayahuasca (AYA) on gestation days (GD) 6-20 at doses corresponding to one-(1X) to eight-fold (8X) the average dose taken by a human adult in a religious ritual, and the pregnancy outcome evaluated on GD21. Rats treated with 4X and 8X doses died during the treatment period (44 and 52%), and those that survived showed kidney injury. Rats surviving the 8X dose showed neuronal loss in hippocampal regions and in the raphe nuclei, and those from the 2X dose neuronal loss in CA1. Delayed intrauterine growth, induced embryo deaths and increased occurrence of foetal anomalies were observed at the 8X dose. At non-lethal doses, AYA enhanced embryolethality and the incidence of foetal soft-tissue and skeleton anomalies. This study suggested that AYA is developmentally toxic and that its daily use by pregnant women may pose risks for the conceptus. KEYWORDS: Ayahuasca; Banisteriopsis caapi; Psychotria viridis; developmental toxicity; gestation losses; serotonin syndrome; teratogenicity PMID: 29522798 DOI: 10.1016/j.reprotox.2018.03.002
2016
Teratogenic Effect of Verbascoside, Main Constituent of Lippia citriodora Leaves, in Mice
Iran J Pharm Res. 2016 Spring;15(2):521-5.
Etemad L1, Zafari R2, Moallem SA3, Vahdati-Mashhadian N4, Skouei Shirvan Z3, Hosseinzadeh H5.
Abstract
Verbascoside (acteoside), a phenyl propanoid glycoside, comprises 0.5 to 3.5 % dry weight of Lippia citriodora leaves. A wide range of biological activities are attributed to verbascoside including anti-inflammatory, antioxidant, anti-bacterial, anti-tumor, anti-fungal, photoprotective as well as chelating effects. The objective of this study is to evaluate the effect of verbascoside on pregnancy outcome in mice. Timed-pregnant mice received doses of 1g/kg/day verbascoside or the vehicle control during organogenesis, intraperitoneally. Maternal body weights were measured throughout pregnancy. The litters were examined for external malformations and skeletal abnormalities. Then they were stained with Alizarin red S and Alcian blue. Maternal exposure to verbascoside throughout pregnancy did not influence the mean of maternal weight gain. Statistically significant difference was not found in mean number of implantation sites, live and resorbed fetuses between control and experiment groups. Our data demonstrate that the main component of L. citriodora, verbascoside using during organogenesis possesses no risk to fetuses. However, more research projects are needed to confirm these findings and determine the exact effects of verbascoside on human embryo development. KEYWORDS: Aloysia triphylla; Herbal medicine; Lippia citriodora; Teratogen; Verbascoside
PMID 27642323 PMCID: PMC5018280
