Neural System - Abnormalities

Introduction

There are many different congenital and maternally derived abnormalities associated with the nervous system. There are potentially 1000's of neurological abnormalities that could be listed on this page, therefore this current page is only a very brief introduction to some neural abnormalities.

Some Recent Findings

Neural Tube Closure

Dysraphism is the term often used to describe the defective fusion of the neural folds. The position and degree of failure of fusion will result in either embryonic death or a range of different neural defects. The way (mode) in which the human neural tube fuses has been a source of contention. In humans, fusion appears to initiate at multiple sites along the neural groove, but this mode may differ from that found in many animal species used in developmental studies.

Human Embryonic Death:

5 weeks with total failure of fusion.
6.5 weeks with opening over the rhombencephalon.
survive beyond 7 weeks with a defect at the frontal and parietal regions.

(Data: Nakatsu etal, 2000^[1]

References

↑ Nakatsu T, Uwabe C, Shiota K. Neural tube closure in humans initiates at multiple sites: evidence from human embryos and implications for the pathogenesis of neural tube defects. Anat Embryol (Berl). 2000 Jun;201(6):455-66.)

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Cite this page: Hill, M.A. (2024, April 28) Embryology Neural System - Abnormalities. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Neural_System_-_Abnormalities

What Links Here?

[1] Nakatsu T, Uwabe C, Shiota K. Neural tube closure in humans initiates at multiple sites: evidence from human embryos and implications for the pathogenesis of neural tube defects. Anat Embryol (Berl). 2000 Jun;201(6):455-66.)

[1]