Mouse Lymph Node Movie 3

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Mouse_adult_lymph_node_03.jpg</wikiflv> Adult Mouse Lymph Node - T cells within the medullary sinus.

Mouse adult lymph node 03.jpg


Passive, unidirectional flow of T cells within the medullary sinus.



Movies show lymphocyte traffic through adult lymph nodes. Cells were isolated from spleens and lymph nodes of BALB/c mice.

Adult Mouse Lymphocyte Motility
Mouse adult lymph node 01.jpg
 ‎‎Lymph Node 1
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Mouse adult lymph node 02.jpg
 ‎‎Lymph Node 2
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Mouse adult lymph node 03.jpg
 ‎‎Lymph Node 3
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Mouse adult lymph node 04.jpg
 ‎‎Lymph Node 4
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Transendothelial
migration
T cell zone Medullary sinus Sinus endothelial
barrier
Mouse adult lymph node 05.jpg
 ‎‎Lymph Node 5
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Mouse adult lymph node 06.jpg
 ‎‎Lymph Node 6
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Mouse adult lymph node 07.jpg
 ‎‎Lymph Node 7
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Mouse adult lymph node 08.jpg
 ‎‎Lymph Node 8
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Bi-directional traffic Cross the sinus
endothelial barrier
T and B cell motility T and B cell coupling
Mouse Immune Movies: Transendothelial migration | T cell zone | Medullary sinus | Sinus endothelial barrier | Bi-directional traffic | cross the sinus endothelial barrier | T and B cell motility | T and B cell coupling | T cell Elimination | Immune System Development | Mouse Development
Links: Immune System Development | Lymph Node Development | Lecture - Lymphatic Structure and Organs

References

Wei SH, Rosen H, Matheu MP, Sanna MG, Wang SK, Jo E, Wong CH, Parker I & Cahalan MD. (2005). Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. Nat. Immunol. , 6, 1228-35. PMID: 16273098 DOI.

Cahalan MD & Parker I. (2008). Choreography of cell motility and interaction dynamics imaged by two-photon microscopy in lymphoid organs. Annu. Rev. Immunol. , 26, 585-626. PMID: 18173372 DOI.

Movie Source

Michael D. Cahalan, Professor and Chair, Department of Physiology and Biophysics, University of California, Irvine. Lab Two-photon imaging movies reproduced with permission of Prof. Cahalan.