Immune System Development: Difference between revisions
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* '''Regulation of lymphatic-blood vessel separation by endothelial Rac1.'''<ref><pubmed>19906871</pubmed></ref> "Sprouting angiogenesis and lymphatic-blood vessel segregation both involve the migration of endothelial cells, but the precise migratory molecules that govern the decision of blood vascular endothelial cells to segregate into lymphatic vasculature are unknown." | * '''Regulation of lymphatic-blood vessel separation by endothelial Rac1.'''<ref><pubmed>19906871</pubmed></ref> "Sprouting angiogenesis and lymphatic-blood vessel segregation both involve the migration of endothelial cells, but the precise migratory molecules that govern the decision of blood vascular endothelial cells to segregate into lymphatic vasculature are unknown." | ||
* '''The development of intestinal lymphoid tissues at the interface of self and microbiota'''<ref><pubmed>19741595</pubmed></ref> "(postnatal) Intestinal lymphoid tissues face the challenging task of inducing adaptive immunity to pathogens, yet maintaining homeostasis with the enormous commensal microbiota. To that aim, the ancient partnership between self and flora has resulted in the generation of a unique set of lymphoid tissues capable of constant large-scale reformatting. A first set of lymphoid tissues, the mesenteric lymph nodes and Peyer's patches, are programmed to develop in the sterile environment of the fetus, whereas a second set of lymphoid tissues, the tertiary lymphoid tissues, are induced to form by the microbiota and inflammation." | |||
* '''Ordering human CD34+CD10-CD19+ pre/pro-B-cell and CD19- common lymphoid progenitor stages in two pro-B-cell development pathways.'''<ref><pubmed>20231472</pubmed></ref>"Here, we show a similar divergence in human B-cell development pathways between the Pax5(+)TdT(-) pre/pro-B differentiation pathway that gives rise to infant B-lineage leukemias and the early-B pathway." | * '''Ordering human CD34+CD10-CD19+ pre/pro-B-cell and CD19- common lymphoid progenitor stages in two pro-B-cell development pathways.'''<ref><pubmed>20231472</pubmed></ref>"Here, we show a similar divergence in human B-cell development pathways between the Pax5(+)TdT(-) pre/pro-B differentiation pathway that gives rise to infant B-lineage leukemias and the early-B pathway." | ||
* '''Epithelial cells in fetal intestine produce chemerin to recruit macrophages.'''<ref><pubmed>19443732</pubmed></ref> "Macrophages are first seen in the fetal intestine at 11-12 wk and rapidly increase in number during the 12- to 22-wk period of gestation. The development of macrophage populations in the fetal intestine precedes the appearance of lymphocytes and neutrophils and does not require the presence of dietary or microbial antigens." | * '''Epithelial cells in fetal intestine produce chemerin to recruit macrophages.'''<ref><pubmed>19443732</pubmed></ref> "Macrophages are first seen in the fetal intestine at 11-12 wk and rapidly increase in number during the 12- to 22-wk period of gestation. The development of macrophage populations in the fetal intestine precedes the appearance of lymphocytes and neutrophils and does not require the presence of dietary or microbial antigens." |
Revision as of 08:38, 19 October 2010
Introduction
Development of the immune system will also link to cardiovascular development notes (blood and vessel) and bone marrow development. Two organs which also relate to this system are the thymus and spleen, which have in the past been included in endocrine and gastrointestinal tract development respectively.
Some Recent Findings
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Spleen Development
The human spleen arises in week 5 within the dorsal mesogastrium as proliferating mesenchyme overlying the dorsal pancreatic endoderm. Cells required for its hemopoietic function arise from the yolk sac wall and near dorsal aorta.
The spleen generates both red and white cells in the 2nd trimester. Note that many embryonic RBCs remain nucleated. | |
D4 Dorsal Mesogastrium (stage 13) |
- Links: Spleen Development
Related Images
Developing Human Thymus (stage 22)
F1 Developing Human Spleen (stage 22)
F2 Developing Human Spleen (stage 22)
F3 Developing Human Spleen (stage 22)
References
Reviews
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Search August 2010 "Immune System Development" All (90551) Review (15955) Free Full Text (28278)
Search Pubmed: Immune System Development | Embryo Immune System Development
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Cite this page: Hill, M.A. (2024, May 21) Embryology Immune System Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Immune_System_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G