Immune System Development: Difference between revisions
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Revision as of 16:25, 22 February 2012
Introduction
Development of the immune system will also link to cardiovascular development notes (blood and vessel) and bone marrow development. Two organs which also relate to this system are the thymus and spleen, which have in the past been included in endocrine and gastrointestinal tract development respectively. There are now also movies showing lymphocyte (B and T cells) traffic within adult lymph nodes.
Some Recent Findings
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Spleen Development
The human spleen arises in week 5 within the dorsal mesogastrium as proliferating mesenchyme overlying the dorsal pancreatic endoderm. Cells required for its hemopoietic function arise from the yolk sac wall and near dorsal aorta.
The spleen generates both red and white cells in the 2nd trimester. Note that many embryonic RBCs remain nucleated. | |
D4 Dorsal Mesogastrium (stage 13) |
- Links: Spleen Development
Thymus Development
The thymus has a key role in the development of an effective immune system as well as an endocrine function.
The thymus has two origins for the lymphoid thymocytes and the thymic epithelial cells. The thymic epithelium begins as two flask-shape endodermal diverticula that form from the third pharyngeal pouch and extend lateralward and backward into the surrounding mesoderm and neural crest-derived mesenchyme in front of the ventral aorta. | |
D4 Developing Thymus (stage 22) |
- Links: Thymus Development
Related Images
Developing Human Thymus (stage 22)
F1 Developing Human Spleen (stage 22)
F2 Developing Human Spleen (stage 22)
F3 Developing Human Spleen (stage 22)
Immune Histology
The images below are from adult immune Lymph Nodes.
Lymphocyte Histology
- Lymphocyte EM Images: T and B Lymphocytes 1 TEM | T and B Lymphocytes 2 TEM | T Lymphocyte SEM | B lymphocyte 1 TEM | B lymphocyte 2 TEM | B lymphocyte 3 TEM | Plasma Cell TEM | T2 Lymphocyte 1 TEM | T2 Lymphocyte 2 TEM | lymphocyte rosettes | T lymphocyte 1 | T lymphocyte 2 | T lymphocyte 3 | T lymphocyte 4 | T lymphocyte 5 | T lymphocyte 6 | B lymphocyte | B lymphocytes TEM | Immune System Development | Blood
Adult Lymphocyte Motility Movies
Transendothelial migration |
T cell zone | T cell zone | Sinus endothelial barrier |
Bi-directional traffic | cross the sinus endothelial barrier |
Transendothelial migration |
T cell zone | T cell zone | Sinus endothelial barrier |
Bi-directional traffic | cross the sinus endothelial barrier |
References
Reviews
<pubmed>21071706</pubmed> <pubmed>18946678</pubmed> <pubmed>15804980</pubmed> <pubmed>15376314</pubmed>
Articles
Search Pubmed
Search August 2010 "Immune System Development" All (90551) Review (15955) Free Full Text (28278)
Search Pubmed: Immune System Development | Embryo Immune System Development
Glossary Links
- Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link
Cite this page: Hill, M.A. (2024, May 21) Embryology Immune System Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Immune_System_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G