Immune System Development: Difference between revisions
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* '''Ordering human CD34+CD10-CD19+ pre/pro-B-cell and CD19- common lymphoid progenitor stages in two pro-B-cell development pathways.'''<ref><pubmed>20231472</pubmed></ref>"Here, we show a similar divergence in human B-cell development pathways between the Pax5(+)TdT(-) pre/pro-B differentiation pathway that gives rise to infant B-lineage leukemias and the early-B pathway." | * '''Ordering human CD34+CD10-CD19+ pre/pro-B-cell and CD19- common lymphoid progenitor stages in two pro-B-cell development pathways.'''<ref><pubmed>20231472</pubmed></ref>"Here, we show a similar divergence in human B-cell development pathways between the Pax5(+)TdT(-) pre/pro-B differentiation pathway that gives rise to infant B-lineage leukemias and the early-B pathway." | ||
* '''Epithelial cells in fetal intestine produce chemerin to recruit macrophages.'''<ref><pubmed>19443732</pubmed></ref> "Macrophages are first seen in the fetal intestine at 11-12 wk and rapidly increase in number during the 12- to 22-wk period of gestation. The development of macrophage populations in the fetal intestine precedes the appearance of lymphocytes and neutrophils and does not require the presence of dietary or microbial antigens." | * '''Epithelial cells in fetal intestine produce chemerin to recruit macrophages.'''<ref><pubmed>19443732</pubmed></ref> "Macrophages are first seen in the fetal intestine at 11-12 wk and rapidly increase in number during the 12- to 22-wk period of gestation. The development of macrophage populations in the fetal intestine precedes the appearance of lymphocytes and neutrophils and does not require the presence of dietary or microbial antigens." | ||
* '''Ontogeny of reticular framework of white pulp and marginal zone in human spleen: immunohistochemical studies of fetal spleens from the 17th to 40th week of gestation.''' <ref><pubmed>19255788</pubmed></ref> "The reticular framework of the periarteriolar lymphoid sheath (PALS), lymph follicle (LF), and marginal zone (MZ) is thus heterogeneous in the fetal spleen, and the development of the heterogeneity is related to the ontogeny of the PALS, LF, and MZ." | |||
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Revision as of 13:15, 20 August 2010
Introduction
Development of the immune system will also link to cardiovascular development notes (blood and vessel) and bone marrow development. Two organs which also relate to this system are the thymus and spleen, which have in the past been included in endocrine and gastrointestinal tract development respectively.
Some Recent Findings
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Spleen Development
The human spleen arises in week 5 within the dorsal mesogastrium as proliferating mesenchyme overlying the dorsal pancreatic endoderm. Cells required for its hemopoietic function arise from the yolk sac wall and near dorsal aorta. The spleen generates both red and white cells in the 2nd trimester. Note that many embryonic RBCs remain nucleated. | |
D4 Dorsal Mesogastrium (stage 13) |
- Links: Spleen Development
Related Images
Developing Human Thymus (stage 22)
F1 Developing Human Spleen (stage 22)
F2 Developing Human Spleen (stage 22)
F3 Developing Human Spleen (stage 22)
References
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Search August 2010 "Immune System Development" All (90551) Review (15955) Free Full Text (28278)
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Cite this page: Hill, M.A. (2024, May 21) Embryology Immune System Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Immune_System_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G