Genital System Development: Difference between revisions

Revision as of 13:20, 14 April 2010

Introduction

Female uterus development

The male and female reproductive systems develop initially "indifferently", it is the product of the Y chromosome SRY gene that makes the difference.Mesonephric duct (Wolffian Duct) and paramesonephric (Müllerian Duct) contribute the majority of male and female internal genital tract respectively.

The mesonephric/paramesonephric duct changes are one of the first male/female differences that occur in development, while external genitaila remain indeterminate in appearance for quite a while.

There are many different issues to consider in the development of the genital system. Importantly its sex chromosome dependence, late embryonic/fetal differential development, complex morphogenic changes, long time-course, hormonal sensitivity and hormonal influences make it a system prone to many different abnormalities.

Historic Embryology - Genital
General: 1901 Urinogenital Tract \| 1902 The Uro-Genital System \| 1904 Ovary and Testis \| 1912 Urinogenital Organ Development \| 1914 External Genitalia \| 1921 Urogenital Development \| 1921 External Genital \| 1942 Sex Cords \| 1953 Germ Cells \| Historic Embryology Papers \| Historic Disclaimer
Female: 1904 Ovary and Testis \| 1904 Hymen \| 1912 Urinogenital Organ Development \| 1914 External Genitalia \| 1914 Female \| 1921 External Genital \| 1927 Female Foetus 15 cm \| 1927 Vagina \| 1932 Postnatal Ovary
Male: 1887-88 Testis \| 1904 Ovary and Testis \| 1904 Leydig Cells \| 1906 Testis vascular \| 1909 Prostate \| 1912 Prostate \| 1914 External Genitalia \| 1915 Cowper’s and Bartholin’s Glands \| 1920 Wolffian tubules \| 1935 Prepuce \| 1935 Wolffian Duct \| 1942 Sex Cords \| 1943 Testes Descent \| Historic Embryology Papers \| Historic Disclaimer

--Mark Hill 09:25, 14 April 2010 (EST) Page Template only - content from original UNSW Embryology site currently being edited and updated.

Some Recent Findings

Textbooks

Human Embryology (2nd ed.) Larson Chapter 10 p261-306
The Developing Human: Clinically Oriented Embryology (6th ed.) Moore and Persaud Chapter 13 p303-346
Before We Are Born (5th ed.) Moore and Persaud Chapter 14 p289-326
Essentials of Human Embryology, Larson Chapter 10 p173-205
Human Embryology, Fitzgerald and Fitzgerald Chapter 21-22 p134-152
Developmental Biology (6th ed.) Gilbert Chapter 14 Intermediate Mesoderm

Objectives

Understand the role of the Y chromosome in sex determination.
Understand the differences in male/female duct develpoment (mesonephric/paramesonephric).
Compare the development of the cloaca in the male and female.
Understand the developmental abnormalities in male and female development.

Computer Activities

Movies

Genital development animations


Urogenital Sinus	Urogenital Septum

Uterus	Female External	Male External	Testis Descent

Primordial germ cell migration (mouse)


Migration 1	Migration 2	Migration 3

Development Overview

The 3 main stages of genital development:

Differentiation of gonad (Sex determination)
Differentiation of internal genital organs
Differentiation of external genital organs

The 2nd and 3rd stages dependent on endocrine gonad. Reproductive development has a long maturation timecourse, begining in the embryo and finishing in puberty.

References

Reviews

Articles

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Cite this page: Hill, M.A. (2024, May 16) Embryology Genital System Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Genital_System_Development

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	There are many different issues to consider in the development of the genital system. Importantly its sex chromosome dependence, late embryonic/fetal differential development, complex morphogenic changes, long time-course, hormonal sensitivity and hormonal influences make it a system prone to many different abnormalities.		There are many different issues to consider in the development of the genital system. Importantly its sex chromosome dependence, late embryonic/fetal differential development, complex morphogenic changes, long time-course, hormonal sensitivity and hormonal influences make it a system prone to many different abnormalities.




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