UNSW Embryology

Version 9.0

An educational resource for learning concepts in embryological development.

© Dr Mark Hill (2010)

Acknowledgements

ISBN: 978 0 7334 2609 4

Introduction

Animation of the Carnegie stages 1 to 23 of human embryonic development during the first 8 weeks (click to play).

Carnegie stage 1 to 23 of Human Development

Your exploration of development can begin in many different ways. Follow the guide shown below (Begin, Next, Finally) or use the internal links shown on the left. These main linked pages will give you access to many different embryology resources. Development is a very dynamic process so Movies is also a good place to start and each set of notes links to related animations.

Begin

	Begin by looking at the Carnegie stages and watching the changes in the embryo's appearance over the first weeks of development.
	An easy introduction is given by the week by week timeline of human development. Young students there are simplified K12 notes. 2009 Medicine students should start here. 2009 Science students should start here

Want to see what is happening in Embryology? Have a look at Embryology News or Embryology site updates. Also see the recent discussion on Fetal Alcohol Syndrome.

Next

The Developmental Notes give information about early developmental processes and overviews of other developmental times and concepts.

Menstrual Cycle	Week 1	Week 2	Week 3
Placenta	Fetal	Birth	Postnatal

The System Notes give information about later developmental processes grouped by embryological and anatomical systems. Each section of notes is organized in a similar way giving: an introduction, overview, developmental abnormalities, mid-embryonic (Carnegie stage 13), late embryonic (Carnegie stage 22), examples of structures, histology and developmental molecular mechanisms.

Neural Notes ----------------- Introduction Stage 13/14 Stage 22 Stage 22 Brain Stage 22 Spinal Cord Week 10 Fetal Ventricular System Cerebrospinal Fluid Gliogenesis Pain Postnatal Neural Neural Assessment Molecular Movies Abnormalities	Cardiovascular Notes ----------------- Introduction Stage 13/14 Stage 22 Stage 22 Select Heart Heart Rate Blood Blood Vessels Lymphatic Postnatal Heart History - Harvey Molecular Heart Movies Vasculature Movies Abnormalities	Musculoskeletal Notes ----------------- Introduction Stage 13/14 Stage 22 Stage 22 Select Somite Limb Axial Skeleton Skull Bone Human Bone Skeletal Muscle Cartilage Joints Adipose Molecular Molecular Axial Movies Limb Abnormalities Abnormalities References	Gastrointestinal Notes ----------------- Introduction Overview Stage 13/14 Stage 13/14 3D Model Stage 22 Stage 22 3D Model Stage 22 Selected Stomach Intestine GIT Folding Liver Gall Bladder Spleen Pancreas Enteric Nervous System Tongue Taste Postnatal Milk Molecular Movies Abnormalities Ultrasound Gastroschisis References
Neural Crest	Genital Notes ----------------- Female X Chromosome Uterus Menstrual Cycle Oogenesis Male Y Chromosome Spermatogenesis Stage 13/14 Embryo Stage 22 Embryo Stage 22 3D Model Stage 22 Highpower Central Pathway References Abnormalities	Endocrine Notes ----------------- Introduction Pituitary Thyroid Adrenal Pancreas Pineal Thymus Gonad Placenta Hypothalmus Parathyroid Adipose Tissue Other Tissues Molecular Stage 13/14 Stage 22 Movies Abnormalities	Body Cavities
Gastrointestinal Notes ----------------- Introduction Overview Stage 13/14 Stage 22 Stage 22 Select Face Tongue Pharyngeal Arch 1 Tongue Taste Movies Head Abnormalities Face Abnormalities Ultrasound Facial Cleft	Sensory Notes ----------------- Introduction Stage 13/14 Stage 22 Stage 22 Selected Week 4 Sensory Placodes Hearing Vision Smell Taste Molecular Abnormalities	Integumentary Notes ----------------- Introduction Abnormalities Histology Dermatomes Glands Mammary Glands Hair Teeth Nails Keratin Overview Molecular Stage 13/14 Stage 22	Respiratory Notes ----------------- Introduction Stage 13/14 Stage 22 Stage 22 Selected Birth Molecular Diaphragm Movies 3D Early Movies 3D Late Abnormalities

Finally

The Movies pages show dynamic processes of development and will require both the Quicktime plug-in and a reasonably quick internet connection. Movies ---------------------------------- Embryo Growth - change in size and appearance Ultrasound - non-invasive prenatal test Abnormal Ultrasound Week 1 - mixing parental genomes and cell division Week 2 - implantation of the Embryo Week 3 - cavities and sheets of cells Week 4 - early organogenesis Stage 13/14 - early Embryo Stage 22 - late Embryo Neural - brain, spinal cord and peripheral ganglia Head and Neck- pharyngeal arches and face Heart- folding and septation Vasculature- blood vessel formation Gastrointestinal- gut structures and rotations Urogenital- kidney, gonads and genitalia Other Embryos- lots of animals Human Embryology - textbook animations Historic - movies from the past Internet - around the world Podcast- audio content Video Podcast- video on the move

Other Embryos

The study of human development has relied extensively on studying the process in many other animal models (chicken, fly, mouse, zebrafish). For those wanting to see the process of development in these and other species the Animal Embryos pages are a good start. Other Embryos ----------------- Bat Chicken Bovine Echidna Fly Frog Guinea Pig Medaka Mouse Platypus Rabbit Rat Worm Zebrafish Embryo Staging Carnegie Staging

When things go wrong in Development

Abnormalities that can occur during development are often described as congenital defects, with the 2 major types being Genetic (inherited) and Environmental (maternal) derived abnormalities. Begin by the introduction page Abnormal Development and each section of notes, week by week and systems, has a page listing and describing related abnormalities. Abnormal Development ----------------- Week 1 Week 2 Neural Heart / Cardiovascular Musculoskeletal Musculoskeletal - Limb Gastrointestinal Tract Head Coelomic cavity Respiratory Neural Crest Senses Senses - Ear Senses - Eye Urogenital Genital Endocrine Genital Integumentary There is also growing evidence that in utero conditions have a significant impact on future health outcomes, look at Fetal Origins Hypothesis.

Postnatal Development

Development does not stop at birth! Postnatal development is a new section of notes covers issues relating to development after birth.

Medical and Science Students

Can find lecture and practical information on the Class Notes page. The 2009 Medicine content is linked below. Alternatively work through the Serial Images of the stage 13/14 and stage 22 embryo. Everything Medicine 2009 ----------------- Found - Intro Embryo Lecture Found - Intro Embryo Practical Found Expert Tutorial-Histology SH - Respiratory Lecture ----------------- BGD - GIT Lecture BGD - GIT Practical Prac1 GIT Manual PDF GIT Development GIT Abnormalities ----------------- BGD - Head Lecture BGD - Head Practical Prac6 Head Manual PDF Head and Neck Development Face Development Ear Development Face Abnormalities ----------------- BGD - Endocrine Lecture Endocrine Development Endocrine Abnormalities ----------------- BDG - Male/Female Lecture BGD - Male/Female Practical Prac12 Male/Female Manual PDF Genital Development Male Development Female Development Genital Abnormalities ----------------- BGD-B Full Prac Manual PDF BGD-B FAQs BGD Phase 2 - Tutorial CBL ILPs 2009 eMed ----------------- Week by Week Movies Audio Development Notes System Notes

Foundations Cycle A 2009 Introduction to Embryology Lecture | Practical	BGD Cycle B 2009 Gastro-Intestinal Tract Embryology Lecture | Practical Face and Ear Embryology Lecture | Practical Endocrine Gland Development Lecture Sexual Differentiation Lecture | Practical BGD Cycle B - 2008 FAQs BGD Phase 2 2009 Applied Embryology and Teratology Tutorial
SH Cycle A 2009 Respiratory Development Lecture

Embryology in the News

The Genome, Stem cells and Cloning so a page of recent topics in development and embryology can be seen at Embryology in the News (see also stem cells and cloning)

Contents by Page

Recent changes/updates to the UNSW Embryology website can be found listed on the 2008 Log page.

A book content style of browsing can be found on Contents by Page. For those used to a More details on how to get started can also be found on the How to Use page.

To put reproduction in a quantitative perspective, there are a number of pages summarizing both Australian, International and World Population trends on Statistics page.

A history of medicine, including embryology, is given by H.S. Williams with additional links to other historical resources including childbirth and Nobel awards on History page.

Glossary

More Information

The current UNSW Embryology website Version 9.0 January 2010.

The last UNSW Embryology website Version 8.0 January 2009.

The current UNSW Embryology DVD Version 7.8 released December 2008. (More? DVD Homepage | About DVD)

The UNSW Embryology CD program Version 5.7 September 2006 has now been discontinued (More? UNSW Embryology DVD).

Recent additions to the UNSW Embryology site can be found logged at Whats New? and have feedback shown at What People Say.....

Medical Students please note that the current site format will allow both didactic Embryology learning (serial sections) and Problem Based Learning (PBL modules under development).

I have also received a lot of email showing that this resource has been useful to researchers, students and the general public, for that I thank you. It encourages me to keep this site as up to date as possible.

For those interested, in collaboration with Prof Kathy Sulik I am currently adding a series of beautiful scanning electron micrograph images of early human embryos to the Carneigie stages section of the website.

Have fun learning!

Dr Mark Hill, 2010.

UNSW Embryology ISBN: 978 0 7334 2609 4

UNSW CRICOS Provider Code No. 00098G